The relationship between adiposity parameters and C-reactive protein values in overweight and obese women

Abstract

Background/Aim. Overweight/obesity has become important health problem in developed countries. It may be related to a presence of low-grade inflammation in white adipose tissue. The aim of this study was to investigate the levels of inflammatory marker C-reactive protein (CRP) and its relation to anthropometric parameters in overweight and obese females. Methods. This study included 200 apparently healthy, overweight and obese women (18-45 years). Their standard and alternative anthropometric parameters [body mass index (BMI), percentage of fat (%F), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI)] were determined and correlated to serum CRP concentration. Results. Average CRP level was 5.56 ± 2.43 mg/L, and it significantly positively correlated to all investigated anthropometric parameters. There was significant difference between overweight and obese group in all investigated anthropometric parameters, as well as in CRP values. When investigated separately, according to BMI, values regarding obese females showed significant correlation between CRP and every investigated anthropometric parameter. In overweight subjects, no such correlation was recorded. In the obese group, all investigated parameters were significantly related to F. In overweight subjects, body weight (BW), BMI, WC and WHtR showed significant relation to F. Conclusion. The significant difference between the overweight and obese group in all parameters of central obesity was found as well as in the CRP levels. In the obese group, we found strong correlation between adiposity measured by fat percentage and parameters of central obesity, while in the overweight group WHR and BAI did not correlate to fat percentage. Our results confirmed that CRP is a valuable marker of metabolic risk in obese females, and BMI, although not so new, is still reliable parameter of adiposity.

Association Between Interleukin 6 and C-Reactive Protein Serum Levels and Body Composition Compartments and Components in Breast Cancer Survivors

“…The BFP was associated with increased serum CRP levels. These results are found in several studies in which an increase in body fat in apparently healthy women aged 18 to 60 is associated with increased CRP concentrations (Pannacciulli et al, 2001) and an increase in BMI (Cesari et al, 2005;Mraovic et al, 2018). In addition, we found that menopausal status modified the relationship between CRP and FMI.…”

“…Adipose tissue is a highly active metabolic complex endocrine tissue that is fundamental to inflammation (Fuentes et al, 2013; Izaola, 2015). Mraovic et al (2018) proposed that the mechanism for the induction of inflammation in obesity is the secretory activity of adipose tissue, which is the site of production of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). In addition to adiposity, age and some diseases, such as cancer, are well-recognized contributing factors to human cytokine imbalance (Cesari et al, 2005; Rea et al, 2018).…”

General psychopathology and impulsivity as the pre-treatment predictors of medical nutrition therapy outcome in the overweight and obese women

“…In the light of the fact that obesity has become the epidemic health threatening condition, its effects on physical health were extensively studied and well-documented [5][6][7]16 . However, the relationship between the psychiatric and/or psychological factors and etiology and obesity treatment is complicated and not well-known.…”

“…Empiric and scientific data confirmed its clear association with plethora of medical conditions (metabolic syndrome, type 2 diabetes, ischemic heart disease, stroke, inflammation, apnea, certain carcinoma, etc.) 1,[5][6][7] and decreased quality of life 8,9 . If the current trend of increased morbidity and mortality due to obesity continues, the life expectancy in future could decrease for the first time in modern history 10 .…”

Obesity Indicators and C-Reactive Protein in Indonesian Adults (More than Equal to 40 Years Old): The Indonesian Family Life Survey 5

“…Obesity is a major public health problem in the world, affecting people in developed and developing countries. 2,8,9 In 2016, 39% of adults aged 18 years and above (39% of men and 40% of women) were overweight; overall, approximately 13% of the world's adult population (11% of men and 15% of women) were obese. 10 Obesity is associated with metabolic syndrome, development of type II diabetes, 11 and coronary heart disease.…”