2010
DOI: 10.1038/nrcardio.2010.161
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The relationship between blood pressure and cognitive function

Abstract: The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure–perfusion–cognition relationships. A decline in vascular reserve… Show more

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Cited by 272 publications
(258 citation statements)
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References 119 publications
(135 reference statements)
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“…11,12 Although resting CBF may be preserved after SCI, cerebrovascular reserve (i.e., the ability of the cerebrovascular system to respond to acute increases in metabolic demand, mechanical or neural stimuli) may be affected, resulting in an insufficient CBF response. 13 Supporting this contention, elegant work by Harper and Glass 14 showed that progressive hypotension abolishes the capacity of the cerebrovasculature to dilate or constrict.…”
Section: Introductionmentioning
confidence: 99%
“…11,12 Although resting CBF may be preserved after SCI, cerebrovascular reserve (i.e., the ability of the cerebrovascular system to respond to acute increases in metabolic demand, mechanical or neural stimuli) may be affected, resulting in an insufficient CBF response. 13 Supporting this contention, elegant work by Harper and Glass 14 showed that progressive hypotension abolishes the capacity of the cerebrovasculature to dilate or constrict.…”
Section: Introductionmentioning
confidence: 99%
“…One of the main pathways linking blood pressure to cognitive degeneration is the decline in vascular reserve capacity which is associated with impaired neurovascular coupling [16]. Despite evidence from epidemiological and intervention studies indicating that anthocyanin intake is linked with improved cognition [15,17] and a slower cognitive decline [18], the mechanisms by which anthocyanins may exert acute effects on brain function remains unclear and evidence is inconsistent.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Consequently, cerebral arterial blood volume (CBV a ) and arterial vessel elasticity decrease, which may in turn alter arterial vascular reactivity to various stimuli. These cerebrovascular alterations could eventually lead to a regional reduction in cerebral blood flow (CBF) and tissue oxygenation, [3][4][5] thereby increasing the risk of stroke, vascular dementia, and cognitive decline. [6][7][8] However, early-stage alterations in the cerebrovasculature are easily modified.…”
Section: Introductionmentioning
confidence: 99%