The Relationship Between Breast Cancer And Risk Factors: A Single-Center Study

Özsoy, Arzu; Barça, Nurdan; Dolek, Betul Akdal; Aktaş, Hafize; Elverici, Eda; Araz, Levent; Ozkaraoglu, Ozlen

doi:10.5152/tjbh.2016.3180

Cited by 11 publications

(12 citation statements)

References 8 publications

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“…Our present study is the first case-control study to evaluate the association of HEI-2015 and its all components score with BC risk. As age is one of the most prominent factor on BC incidence (Ozsoy et al, 2017), the strength of our study is adjusting for age (one-by-one). However, our study has further limitations.…”

Section: Discussionmentioning

confidence: 99%

Healthy eating index-2015 and breast cancer: a case-control study

Safabakhsh

Shab‐Bidar

Imani

2021

NFS

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Purpose Recently, evidences have suggested that healthy eating index (HEI), an index-based dietary pattern, may be a predictor for the risk of cancer. This paper aims to examine the association of HEI-2015 and its all components scores with the risk of breast cancer (BC), separately, among Iranian women. Design/methodology/approach In the present hospital-based, case-control study, 150 age-matched of cases (newly diagnosed female) and 150 controls were recruited. Data of dietary habits and anthropometric measures were obtained, and eventually, the HEI-2015 score was calculated. Multivariate odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship between the risk of BC across tertiles (Ts) of total HEI-2015 and its all component scores. Findings The results presented that in adjusted model, there was no significant difference between total HEI-2015 (p = 0.14) and its all component scores (p > 0.09) of healthy subjects and females with BC. Moreover, multivariable logistic regression analyses indicated that HEI-2015 score was not associated with the risk of BC in either crude (p-trend = 0.94) or adjusted (p-trend = 0.73) analyses. In the analyses of HEI-2015 components scores, it was observed that the scores of grains (OR, 0.53; 95% CI, 0.30–0.94) and total protein foods (OR, 0.13; 95% CI, 0.02–0.58) may have a relation with BC risk in crude model but after adjusting for BC risk factors, the mentioned associations changed to non-significant. Originality/value The findings of current study suggested that there was no significant association of total HEI-2015 and its components scores, independently, with BC incidence among Iranian women.

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Section: Discussionmentioning

confidence: 99%

Healthy eating index-2015 and breast cancer: a case-control study

Safabakhsh

Shab‐Bidar

Imani

2021

NFS

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“…For this reason, the common treatments of this cancer have undesired harmful effects and natural compounds with favorable therapeutic properties may be more beneficial than synthetic materials. 23,24 Accordingly, curcumin as a natural component was considered in recent study and CAP and chitosan-TPP-nanoparticles were applied for improving the drawbacks of curcumin in solubility and drug delivery system, respectively.…”

Section: Discussionmentioning

confidence: 99%

Cold atmospheric plasma modification of curcumin loaded in tri‐phosphate chitosan nanoparticles enhanced breast cancer cells apoptosis

Sadoughi

Irani

Bagheri‐Khoulenjani

et al. 2020

Polymers for Advanced Techs

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The anti-cancer mechanisms of curcumin have been reported to include suppressions of angiogenesis and tumor proliferation. The main goal of this research is to increase the solubility of curcumin by cold atmospheric plasma (CAP) and assess the effects of modified curcumin by charging with tri-polyphosphate chitosan nanoparticles for MCF-7, MDA-MB-231 breast cancer cells, and human fibroblast cells. Curcumin modification was done by CAP and its solubility was evaluated by spectrophotometry. After loading modified curcumin into nano-chitosan-TPP, nanocurcumin was characterized by scanning electron microscopy. Cellular viability and apoptosis of treated cells were assessed by MTT and Annexin V. The changes of messenger RNA expression of TP5353 and VEGF genes were analyzed by real-time PCR. CAP was able to transform the curcumin to possess hydrophilic characteristics after 90 seconds. The mean diameter of Curcumin loaded chitosannanoparticles (NPs) were determined as 48 nm. MTT results showed that the IC 50 of nano Cur-chitosan-TPP was effectively decreased compared to free curcumin in MCF-7 (15 μg/mL at 72 hours vs 20 μg/mL at 48 hours). Additionally, nano Cur-chitosan-TPP had no significant effect on normal cells (Human dermal fibroblas: HDF), whereas it also decreased the viability of triple negative breast cancer cell line (MDA-MB-231). Realtime PCR results showed that expression level of TP53 gene was upregulated (P = .000), whereas VEGF gene downregulated (P = .000) in treated MCF-7 cells. Curcumin loaded chitosan nanoparticles have led to an induction of apoptosis (79.93%) and cell cycle arrest (at S and G2M). Modified-curcumin-tri-polyphosphate chitosan nanoparticles using CAP can be considered as a proper candidate for breast cancer treatment.

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“…BRCA1 5382insC carriers had relatives with BC, bilateral BC, GIT, lung and brain tumors, Table 4. Ozsoy et al, (2017) suggested that family history of BC is the most important risk factor among all other risk factors. Similarly, other studies such as (Jasinska and Krzyzosiak, 2001;Cherbal et al, 2010) found a strong family history of BC in all carriers of BRCA1 5382insC mutation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Heterozygous BRCA1 5382ins Founder Mutation in a Cohort of Egyptian Breast Cancer Female Patients Using Pyrosequencing Technique

Mogahed

Hamed

Moursy

et al. 2020

Asian Pac J Cancer Prev

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Breast cancer (BC) is the most frequently occurring cancer among women, representing a quarter of all diagnosed cancers (Bray et al., 2018). It is also the first cause of cancer-related deaths among them(DeSantis et al., 2015). In Egypt, according to the latest National Cancer Registry Program (NCRP), BC is the most common cancer among women representing 32.04% of total cancers (Ibrahim et al., 2014). BRCA1 and BRCA2 (breast cancer predisposition gene 1/2)are the strongest susceptibility genes for BCaccounting for up to half of the heritable mutations in BC and inherited in an autosomal dominant pattern with incomplete penetrance (Tung et al., 2015). Defective DNA double-strand repair is a characteristic of germline mutations in BRCA1 and BRCA2 genes in all cells expressing them (Mehrgou and Akouchekian, 2016).They are also classified as pathogenic variants or

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The Relationship Between Breast Cancer And Risk Factors: A Single-Center Study

Cited by 11 publications

References 8 publications

Healthy eating index-2015 and breast cancer: a case-control study

Healthy eating index-2015 and breast cancer: a case-control study

Cold atmospheric plasma modification of curcumin loaded in tri‐phosphate chitosan nanoparticles enhanced breast cancer cells apoptosis

Analysis of Heterozygous BRCA1 5382ins Founder Mutation in a Cohort of Egyptian Breast Cancer Female Patients Using Pyrosequencing Technique

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