The relationship between cholecystectomy and colon cancer: An Iowa study

Abstract

The relationship between cholecystectomy and subsequent development of colon cancer was investigated in a case-control study of 165 patients with histologically proven adenocarcinoma of the colon. These patients were from a community in Iowa where incidence of colon cancer was considered to be higher than average in the United States. The relative risk of developing colon cancer after cholecystectomy was shown to be 2.11 (P = .009) for the entire series and 2.91 (P = .002) for the female group. There was a difference of frequency in developing colon cancer after cholecystectomy between the right- and left-sided colons; the relative risk of the right versus the left colon cancer was 2.31 (P = .019). The other factors, including blood group, red cell indices, obesity, serum cholesterol, colonic diverticula, and co-existence of hyperplastic or adenomatous polyp disclosed no significant relation to colon cancer developed after cholecystectomy.

Cholecystectomy and the risk of alimentary tract cancers: A systematic review

“…The highest reported RR was 2.11 (95%CI: 1.19-3.85) [54] . 3683 March 28, 2015|Volume 21|Issue 12| WJG|www.wjgnet.com Ichimiya et al [26] , 1986, reported on oesophageal cancer without specifying pathology of cancer.…”

“…Three case-control studies reporting 132 cases of colorectal cancer found a significant association between cholecystectomy and colorectal cancers [43,53,54] . The highest reported RR was 2.11 (95%CI: 1.19-3.85) [54] .…”

Cholecystectomy and colorectal cancer: Evidence from a cohort study on diet and cancer

“…This result in women is in accordance with many other studies (e.g., Linos et al, 1981;Vernick and Kuller, 1981;Kune et nl., 1988;Lee et al, 1989;Berkel et al, 1990). However, we require more cases to draw more definite conclusions with respect to sub-site.…”

“…Among the studies with a reasonable number of cases (e.g., more than 30 cancer cases with cholecystectomy), the casecontrol studies by Vernick and Kuller (1981), Lee et al (1989) and Berkel et al (1990) and the follow-up studies by Linos et al (1981) in the USA and Nielsen et al (1991) in Iceland reported a positive association. The last study found the increased risk in men only, as in the autopsy study by Breuer et al (1988) on gallstones and colorectal cancer.…”

Gallstone disease is associated with rectal cancer: a meta-analysis

“…The search strategy used combinations of the keywords (1) rectal; (2) colorectal (3) neoplasm; (4) cancer; (5) carcinoma; (6) adenocarcinoma; (7) tumour or tumor; (8) cholecystectomy; (9) gallbladder surgery (10) gallstones; (11) cholelithiasis; (12) cholecystolithiasis; and (13) choledocholelithiasis. Additional manual searches were made using the reference lists from review and original articles to retrieve other papers relevant to the topic.…”