The relationship between corneal biomechanics and anterior segment parameters in the early stage of orthokeratology

Chen, Renai; Mao, Xinjie; Jiang, Jun; Shen, Meixiao; Liang, Yan; Zhang, Bin; Liu, Fan

doi:10.1097/md.0000000000006907

Cited by 19 publications

(20 citation statements)

References 28 publications

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“…Some authors found that the main change in corneal thickness was in the corneal epithelium after OK lens wear [2,9,17,18]. However, there is still no internationally unified view on how the corneal epithelium is redistributed after lens wear [16,[19][20][21][22]. Lian et al [16] found central, horizontal, and vertical meridian epithelium thinning, horizontal meridian nasal temporal side paracentral epithelial thickening, and above vertical meridian paracentral epithelium thinning at 1 month of lens wear by UHR-OCT. Chen et al [19] found that the central epithelium thinned and the corneal stroma thickened at 1 day of lens wear.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is still no internationally unified view on how the corneal epithelium is redistributed after lens wear [16,[19][20][21][22]. Lian et al [16] found central, horizontal, and vertical meridian epithelium thinning, horizontal meridian nasal temporal side paracentral epithelial thickening, and above vertical meridian paracentral epithelium thinning at 1 month of lens wear by UHR-OCT. Chen et al [19] found that the central epithelium thinned and the corneal stroma thickened at 1 day of lens wear. Nieto-Bona et al [20] observed that the central 2 mm corneal epithelium was thinning, while there was no obvious change in corneal stroma by confocal microscope.…”

Section: Discussionmentioning

confidence: 99%

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Redistribution of the corneal epithelium after overnight wear of orthokeratology contact lenses for myopia reduction

Zhang

et al. 2020

Contact Lens and Anterior Eye

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Background: To investigate changes in the corneal thickness profile in juvenile myopia after overnight wear of orthokeratology lenses (OK). Methods: A total of 53 juveniles (53 right eyes) successfully wore OK between January 2016 and July 2017 and they were reviewed one day, one week and one month after first wearing it. Epithelial and corneal data were obtained by optical coherence tomography (OCT). Changes in uncorrected visual acuity, refractive error, corneal refractive power, and epithelial and corneal thickness were analyzed before and after wear of OK. Results: The corneal epithelium was reshaped after 1 day of OK; the myopia degree was reduced, and uncorrected visual acuity reached 0 logMAR at 1 week. The central (2 mm) average epithelial thickness was 52.04 ± 2.35 μm, 49.25 ± 2.67 μm, 45.91 ± 2.80 μm, and 47.53 ± 3.44 μm before and after 1 day, 1 week, and 1 month of OK, respectively (t = 4.497, 9.741, and 7.340, respectively, P < 0.001). The central epithelium was thinnest at 1 week, when the average thinning of 6.13 ± 1.67 μm accounted for approximately 11.78 % ± 3.21 % of the total epithelium thickness at baseline. The epithelial thickness of the reverse curve zone was 51.83 ± 2.49 μm, 57.62 ± 3.01 μm, 59.43 ± 3.19 μm, and 60.22 ± 2.75 μm before and after 1 day, 1 week, and 1 month of OK, respectively, showing a significant increase over time (t=-4.752,-6.208, and-6.848, respectively, P < 0.001). Conclusion: In the early stage of OK, the corneal epithelium was redistributed very quickly. The central epithelium became thin, while the epithelium of the reverse curve zone correspondingly thickened. Effectively reduced the refractive power of the cornea equivalent to the effect of adding a concave spectacle lens, which ensures uncorrected vision after removal of the lenses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Redistribution of the corneal epithelium after overnight wear of orthokeratology contact lenses for myopia reduction

Zhang

et al. 2020

Contact Lens and Anterior Eye

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“…After orthokeratology, the corneal epithelium is reduced 29,30 , but the corneal stroma thickens 31,32 . These changes in the morphological and histological properties of the cornea may alter its biomechanical properties 33 . The current study applied both a dynamic bidirectional corneal applanation technology (i.e.…”

Section: Discussionmentioning

confidence: 99%

Association between long-term orthokeratology responses and corneal biomechanics

Lam

Hon

Leung

et al. 2019

Sci Rep

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Myopia is very prevalent worldwide, especially among Asian populations. Orthokeratology is a proven intervention to reduce myopia progression. The current study investigated association between baseline corneal biomechanics and orthokeratology responses, and changes of corneal biomechanics from long-term orthokeratology. We fitted 59 adult subjects having myopia between −4.00D to −5.00D with overnight orthokeratology. Corneal biomechanics was measured through dynamic bidirectional corneal applanation (in terms of corneal hysteresis, CH and corneal resistance factor, CRF) and corneal indentation (in terms of corneal stiffness, S and tangent modulus, E). Subjects with poor orthokeratology responses had lower E (mean 0.474 MPa) than subjects with good orthokeratology responses (mean 0.536 MPa). Successful orthokeratology for 6 months resulted in reducing CH (reduced by 5.8%) and CRF (reduced by 8.7%). Corneal stiffness was stable, but E showed an increasing trend. Among subjects with successful orthokeratology, a higher baseline S resulted in greater myopia reduction (Pearson correlation coefficient, r = 0.381, p = 0.02).

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“…17]. Lian Y[10] found central, horizontal, and vertical meridian epithelium thinning, horizontal meridian nasal temporal side paracentral epithelial thickening, and above vertical meridian paracentral epithelium thinning at 1 mo of lens wear by UHR-OCT. Chen R[14] found that the central epithelium thinned and the corneal stroma thickened at 1 day of lens wear. Nieto-Bona-A[15] observed that the central 2-mm corneal epithelium was thinning, while there was no obvious change in corneal stroma by confocal microscope.…”

mentioning

confidence: 99%

Redistribution of the Corneal Epithelium After Overnight Wear of Orthokeratology Contact Lenses for Myopia Reduction

Zhang

et al. 2019

Preprint

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Background: To investigate changes in the corneal epithelium topographic map in juvenile myopia after overnight wear of orthokeratology lenses (OK). Methods: A total of 53 juveniles (53 right eyes) successfully wore OK and were reviewed in a timely manner from January 2016 to July 2017. Epithelial and corneal data were obtained by optical coherence tomography (OCT). Changes in uncorrected visual acuity, diopter, corneal refractive power, and epithelial and corneal thickness were analyzed before and after 1 day, 1 week, and 1 mo of overnight wear of OK. Results: The corneal epithelium was reshaped after 1 day of OK; the myopia degree was reduced, and uncorrected visual acuity reached 0 logMAR at 1 week. The central (2-mm) average epithelial thickness was 52.04±2.35 μm, 49.25±2.67 μm, 45.91±2.80 μm, and 47.53±3.44 μm before and after 1 day, 1 week, and 1 mo of OK, respectively (t=10.122, 10.782, and 10.673, respectively, P≤0.001). The central epithelium appeared to have a thinning trend, which was obvious at 1 week, when the average thinning of 6.13±1.67 μm accounted for approximately 11.78%±3.21% of the total epithelium thickness. The epithelial thickness of the reverse curve zone was 51.83±2.49 μm, 57.62±3.01 μm, 59.43±3.19 μm, and 60.22±2.75 μm before and after 1 day, 1 week, and 1 mo of OK, respectively, showing a significant increase over time (t=5.325, 6.177, and 6.312, respectively, P≤0.001). Conclusion: In the early stage of OK, the corneal epithelium was redistributed very quickly. The central epithelium became thin, while the epithelium of the reverse curve zone correspondingly thickened and achieved a plateau at 1 mo. Epithelial redistribution guaranteed uncorrected visual acuity after removal of OK.

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The relationship between corneal biomechanics and anterior segment parameters in the early stage of orthokeratology

Cited by 19 publications

References 28 publications

Redistribution of the corneal epithelium after overnight wear of orthokeratology contact lenses for myopia reduction

Redistribution of the corneal epithelium after overnight wear of orthokeratology contact lenses for myopia reduction

Association between long-term orthokeratology responses and corneal biomechanics

Redistribution of the Corneal Epithelium After Overnight Wear of Orthokeratology Contact Lenses for Myopia Reduction

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