The Relationship between Dietary Inflammatory Index,  Pulmonary Functions and Asthma Control in Asthmatics

Özbey, Ümüş; Uçar, Aslı; Shivappa, Nitin; Hébert, James R.

doi:10.18502/ijaai.v18i6.2173

Cited by 7 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results showed that there were positive significant relationships between DII and CRP, hospitalization, neutrophil, WBC, NLR, and disease severity. Similar to our results, various observational studies have reported that higher DII increases the risk of lung-related inflammatory conditions such as asthma (36,37) and COVID-19 (13,38). Similarly, studies conducted on other health conditions have reported positive associations between CRP and immune system biomarkers with DII values (39, 40).…”

Section: Discussionsupporting

confidence: 90%

“…Our results showed that higher intakes of anti-inflammatory micro-nutrients (vitamins A, D, and E as fat-soluble vitamins, vitamins C, B1, B2, B3, B6, and B9 as water-soluble vitamins, betacarotene, iron, magnesium, zinc, and selenium) led to the lower DII and E-DII values. Similarly, Özbey et al reported that intakes of vitamins A, E, and C had a negative relationship with DII values (36). Kim et al also demonstrated that dietary vitamins A, D, E, C, B1, B2, B3, B6, and B9, and beta-carotene, zinc, selenium, and magnesium were negatively associated with DII values (45).…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

et al. 2023

Self Cite

View full text Add to dashboard Cite

BackgroundInflammation and cytokine storm have been reported to be the main cause of acute symptoms of coronavirus disease (COVID-19). Diet-induced inflammation may affect the condition of patients with COVID-19. Therefore, this study aimed to investigate the relationship between disease severity, inflammatory and immune system biomarkers, and the dietary inflammatory index (DII) in patients with COVID-19.MethodsThis cross-sectional study was conducted on 500 adult patients with COVID-19. Patients were divided into mild, moderate, and severe conditions based on clinical and laboratory evidence. A validated food frequency questionnaire (FFQ) was used to determine DII and energy-adjusted DII (E-DII) scores. The serum C-reactive protein (CRP) level and blood cell count were measured for all patients. Multiple linear regression was used to explore the association between DII and E-DII and CRP, blood cell counts, and hospitalization in patients with COVID-19.ResultsCoronavirus disease (COVID-19) patients with higher DII had higher consumption of fat and carbohydrate and lower intakes of protein, anti-inflammatory nutrients, garlic, caffeine, tea, onion, and fiber (P < 0.05). There was a positive association between DII and CRP (β = 1.024, P < 0.001), hospitalization (β = 1.062, P < 0.001), WBC count (β = 0.486, P < 0.009), neutrophil count (β = 0.565, P < 0.001), and neutrophil-to-lymphocyte ratio (β = 0.538, P < 0.001) and a negative association between DII and the lymphocyte count (β = −0.569, P < 0.001). There was a positive association between E-DII and hospitalization (β = 1.645, P < 0.001), WBC count (β = 0.417, P < 0.02), and neutrophil-to-lymphocyte ratio (β = 0.35, P < 0.03).ConclusionThere is a positive correlation between DII and inflammation, immune hyperactivation, and length of hospital stay in patients with COVID-19. Further longitudinal studies are necessary.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…These results are not consistent with our findings because the authors did not consider DII in their analyses; moreover, the outcome of interest was asthma exacerbations, which could be considered as a component of asthma burden. More recently, a cross‐sectional study on Turkish adults with asthma showed a significant inverse correlation between DII computed on a 24‐hour recall questionnaire and asthma control 36 . Despite relevant differences in the study population and design, these results are in line with our findings, highlighting the adverse effect of a pro‐inflammatory diet on asthma control, which can be considered a component for asthma burden.…”

Section: Discussionsupporting

confidence: 90%

“…More recently, a cross-sectional study on Turkish adults with asthma showed a significant inverse correlation between DII computed on a 24-hour recall questionnaire and asthma control. 36 Despite relevant differences in the study population and design, these results are in line with our findings, highlighting the adverse effect of a pro-inflammatory diet on asthma control, which can be considered a component for asthma burden.…”

Section: Discussionsupporting

confidence: 88%

The Dietary Inflammatory Index and asthma burden in children: A latent class analysis

Cilluffo

Han

Ferrante

et al. 2021

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Introduction Unbalanced dietary intake has been increasingly recognized as an important modifiable risk factor for asthma. In this study, we assessed whether a pro‐inflammatory diet is associated with higher asthma burden in three steps: (1) identification of asthma latent classes (LC) based on symptoms, indoor exposures, and pulmonary function; (2) identification of risk factors associated with LC membership; and (3) estimation of the probabilities of LC membership with variation in DII. Methods A cross‐sectional study on 415 children aged 5–14 years (266 with persistent asthma and 149 controls). LC analysis was performed in asthmatic children. The DII was calculated based on a semiquantitative food frequency questionnaire. Elastic net logistic regression was used to investigate whether increasing DII was associated with worse asthma burden. Results Two LCs were identified. Children in Class 1, “high burden,” had higher symptom burden and worse lung function. Children in Class 2, “low burden,” had lower symptom burden and less impaired lung function but were more subject to indoor exposures. DII was the only risk factor significantly associated with Class 1 membership. As the DII increased (from −4.0 to +4.0), the probability of Class 1 membership increased from 32% to 65% when compared with control group, whereas it increased from 41% to 72% when compared with Class 2. Conclusions We identified two phenotypes of persistent asthma associated with different disease burden linked to indoor exposures. An increasing DII was associated with high‐burden asthma, providing further evidence about the role of a pro‐inflammatory diet in asthma morbidity.

show abstract

“…Regarding the impact of an overall healthy diet as a disease modifier, a healthier diet was associated in our study with a lower risk of uncontrolled asthma but the association did not reach statistical significance. Five studies have been published so far, all among middle-aged adults and overall, they reported mixed findings as follows: three studies reported an association between an overall healthy diet and lower uncontrolled asthma [ 48 – 50 ], one reported no association [ 51 ], and one reported a borderline significant association in women [ 18 ]. Published studies are very heterogeneous in term of tools used to evaluate asthma control as follows: two used the ACT [ 18 , 50 ] and three used the asthma control questionnaire (ACQ) [ 48 , 49 , 51 ]; in terms of tools used to collect dietary data, three used 24-h dietary records [ 18 , 48 , 50 ], and two used a FFQ [ 49 , 51 ]; and in terms of tools used to estimate the overall diet, one used the Dietary Approaches to Stop Hypertension (DASH) score [ 48 ], one used the DII [ 50 ], two used the Mediterranean diet score [ 49 , 51 ], and one used the AHEI-2010 [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study

et al. 2022

View full text Add to dashboard Cite

Purpose The impact of a healthy diet on asthma prevention and management, particularly among elderly women, remains poorly understood. We investigated whether a healthy diet would be associated with fewer asthma symptoms, and, among women with asthma, with reduced uncontrolled asthma and metabolic-related multimorbidity. Methods We included 12,991 elderly women (mean age = 63 years) from the Asthma-E3N study, a nested case–control study within the French E3N cohort. Negative binomial regressions were used to analyse associations between a healthy diet [evaluated by the Alternate Healthy Eating Index-2010 (AHEI-2010)] and a validated asthma symptom score, and logistic regressions to analyse associations between the AHEI-2010 with the asthma control test and multimorbidity profiles previously identified by clustering methods on medications used. Results After adjustment for potential confounders, a linear inverse association was found between the AHEI-2010 score and the asthma symptom score [mean score ratio (95% CI) = 0.82 (0.75–0.90) for the highest versus lowest quintile; p for trend < 0.0001]. In addition, women in the highest versus lowest AHEI-2010 tertile were at a lower risk to belong to the “Predominantly metabolic multimorbidity-related medications profile” compared to the “Few multimorbidity-related medications" profile [OR 0.80 (0.63–1.00) for tertile 3; p for trend = 0.05; n = 3474]. Conclusion Our results show that a healthy dietary intake could play an important role in the prevention and management of asthma over the life course.

show abstract

The Relationship between Dietary Inflammatory Index, Pulmonary Functions and Asthma Control in Asthmatics

Cited by 7 publications

References 30 publications

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

The Dietary Inflammatory Index and asthma burden in children: A latent class analysis

Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study

Contact Info

Product

Resources

About