The relationship between epicardial adipose tissue and P wave and QT dispersions

Çiçek, Yüksel

doi:10.5543/tkda.2015.47598

Cited by 6 publications

(1 citation statement)

References 25 publications

(37 reference statements)

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“…EFT mainly covers all coronary vessels. Also it surrounds the outer wall of the right ventricle and the left ventricular apex; hence, the EFT is known to have an influential effect on human cardiac conduction [ 7 , 8 ]. The possible relation between EFT thickness (EFTt) and ventricular TDR was analysed.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?

Yılmaz

Kayançiçek

Gözel

et al. 2020

Arch Med Sci Atheroscler Dis

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Introduction Epicardial fat is a tissue that releases many proinflammatory and atherogenic mediators, with endocrine and paracrine effects on the heart. In this study, the implication of the EFT thickness (EFTt) on transmural dispersion of repolarisation (TDR) was analysed utilizing the T-wave peak to end interval (Tp-Te), the Tp-Te dispersion (Tp-Te (d)), and the Tp-Te/QT ratio. Material and methods One thousand seven hundred and thirteen subjects were enrolled in the research. The subjects were chosen to be healthy individuals, without any cardiovascular/systemic disorders or risk factors for atherosclerosis. Transthoracic echocardiography (TTE) was applied to all subjects, and EFTt was measured in both diastole and systole. The ECG measurements were taken from standard 12-lead surface ECG. Results Correlation analysis revealed that the EFTt is highly associated with the Tp-Te interval, Tp-Te/QT ratio, Tp-Te (d), increasing age, body mass index (BMI), body surface area (BSA), left ventricular (LV) mass, LV mass index, plasma glucose during fasting, triglycerides, and low-density lipoprotein cholesterol. Conclusions The study results showed that increased EFTt was associated with increased TDR values of Tp-Te, Tp-Te (d), and Tp-Te/QT ratio, even in the absence of other factors that could increase TDR and EFTt. Therefore, it can be stated that increased EFTt may cause an increase the risk for ventricular arrhythmia.

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Section: Introductionmentioning

confidence: 99%

Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?

Yılmaz

Kayançiçek

Gözel

et al. 2020

Arch Med Sci Atheroscler Dis

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Obesity as a risk factor for cardiac arrhythmias

Patel

Reddy

et al. 2022

bmjmed

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Obesity is global health problem with an estimated three billion people worldwide being classified as overweight or obese. In addition to being associated with a range of adverse health outcomes, obesity is linked to higher risks of atrial and ventricular arrhythmias, as well as sudden cardiac death. Obesity is a multifactorial disease that often co-exists with hypertension, diabetes, and sleep apnoea, which are also independent risk factors for cardiac arrhythmias. Nevertheless, compelling evidence suggests that increasing adiposity is an independent proarrhythmic risk factor and that weight loss can be a mitigating and preventative intervention to reduce arrhythmia incidence. This review briefly outlines the economic and social burden of obesity and summarises evidence for the direct and indirect effects of increasing adiposity on risk of atrial and ventricular arrhythmias. The paper also summarises the evidence for electrocardiographic changes indicative of obesity-related atrial and ventricular remodelling and how weight reduction and management of comorbidity might reduce arrhythmic burden.

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Epicardial adipose tissue as a mediator of cardiac arrhythmias

Patel

Hwang

Liebers

et al. 2022

American Journal of Physiology-Heart and Circulatory Physiology

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Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly explained by concurrent cardiometabolic ill-health, growing evidence suggests that increasing adiposity independently confers risk for arrhythmias. Amongst fat depots, epicardial adipose tissue (EAT) exhibits a proinflammatory secretome, and given the lack of fascial separation, has been implicated as a transducer of inflammation to the underlying myocardium. The present review explores the mechanisms underpinning adverse electrophysiological remodelling as a consequence of EAT accumulation and the consequent inflammation. We first describe the physiological and pathophysiological function of EAT and its unique secretome, and subsequently discuss the evidence for ionic channel and connexin expression modulation as well as fibrotic remodelling induced by cytokines and free fatty acids that are secreted by EAT. Finally, we highlight how weight reduction and regression of EAT volume may cause reverse remodelling to ameliorate arrhythmic risk.

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The relationship between epicardial adipose tissue and P wave and QT dispersions

Abstract: A significant association between EAT and PWd was demonstrated in the study. While EAT is related to both increased PWd and left atrial size, left atrial diameter seems to be more important than EAT for prediction of atrial fibrillation (AF) in patients with normal coronary arteries.

Cited by 6 publications

References 25 publications

Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?

Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?

Obesity as a risk factor for cardiac arrhythmias

Epicardial adipose tissue as a mediator of cardiac arrhythmias

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