The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain

Selina, Aksak Karamese; Karameşe, Murat; Karakuş, Emre; Malkoç, Ismail; Ünal, Bünyami; Gündoğdu, Cemal

doi:10.1016/j.acthis.2015.08.005

Cited by 4 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 7 , 11 , 12 Furthermore, it revealed that HPIP could mediate specific estrogen receptor signaling in several cancer cells. 16 , 17 , 29 , 30 These data provide important evidence that elucidates the mechanism by which HPIP expression contributes to carcinogenesis and tumor progression.…”

Section: Discussionmentioning

confidence: 85%

HPIP: a predictor of lymph node metastasis and poor survival in cervical cancer

Cao

Sun

Lin

et al. 2017

OTT

View full text Add to dashboard Cite

BackgroundThe aim of this study was to explore the relationships of HPIP expression status with the clinicopathological variables and survival outcomes of patients with cervical cancer (CC).MethodsWe compared the HPIP expression of 119 samples from CC tissues, 20 from cervical intraepithelial tissues, and 20 from normal cervical tissues by using immunohistochemical staining.ResultsIt was observed that the ratio of elevated HPIP expression was higher in CC tissues than in cervical intraepithelial neoplasia (P=0.017) and normal cervical tissues (P=0.001). In addition, there was an association between HPIP and clinicopathological factors, such as histological grade (P<0.001), stromal infiltration (P=0.015), lymph node metastasis (P<0.001), lymphovascular space invasion (LVSI; P=0.026), and recurrence (P=0.029). Furthermore, multivariate Cox regression analysis revealed that high HPIP expression (P=0.027 and P=0.042) as well as the International Federation of Gynaecology and Obstetrics stage (P=0.003 and P=0.009), lymph node metastasis (P=0.031 and P=0.017), and LVSI (P=0.024 and P=0.046) were independent prognostic factors. In addition, we demonstrated that high HPIP expression (P=0.003) and LVSI (P<0.001) were independently related to lymph node metastasis.ConclusionElevated HPIP expression may contribute to the progression and metastasis of CC and may also serve as a new biomarker to predict the prognosis of CC.

show abstract

Section: Discussionmentioning

confidence: 85%

HPIP: a predictor of lymph node metastasis and poor survival in cervical cancer

Cao

Sun

Lin

et al. 2017

OTT

View full text Add to dashboard Cite

show abstract

“…Wang et al6 demonstrated that HPIP may have a vital function in PI3K/AKT signaling transduction pathways, which regulate multiple biological behavior, such as apoptosis, cell carcinogenesis, and epithelial–mesenchymal transition. Some studies have inferred that HPIP can mediate specific estrogen receptor signaling in several cancer cells 13,14,20,21. Feng et al8 speculated that HPIP could activate MAPK/ERK pathway in colorectal cancer cell, thereby promote tumor proliferation and migration 8.…”

Section: Discussionmentioning

confidence: 99%

Expression of HPIP in epithelial ovarian carcinoma: a clinicopathological study

Wang

Meng

Liu

et al. 2016

OTT

View full text Add to dashboard Cite

ObjectivesHematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) plays an important role in cancer invasion and metastasis. The aim of this study is to investigate the expression of HPIP in epithelial ovarian cancer (EOC).Patients and methodsImmunohistochemical method was performed using 42 normal ovarian specimens and 145 specimens with EOC. The correlations of HPIP expression with the clinicopathological factors and prognosis of EOC patients were evaluated. Statistical analyses were performed using the chi-square test, multivariate Cox proportional hazard, and Kaplan–Meier method.ResultsHPIP expression in EOC was higher than that in normal tissues (P<0.001). HPIP expression was significantly associated with histological grade, International Federation of Gynecology and Obstetrics stage, and lymphatic metastasis of EOC (P<0.05). Patients with high HPIP expression had poorer overall survival and disease-free survival (P<0.001) compared with patients with low HPIP expression. Multivariate Cox analysis demonstrated that HPIP was an independent factor for overall survival and disease-free survival (P<0.05).ConclusionHPIP may be a valuable biomarker for predicting the prognosis of EOC patients and may serve as a potential target for cancer therapy.

show abstract

Two decades of a protooncogene HPIP/PBXIP1: Uncovering the tale from germ cell to cancer

Khumukcham

Manavathi

2021

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

View full text Add to dashboard Cite

The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain

Cited by 4 publications

References 28 publications

HPIP: a predictor of lymph node metastasis and poor survival in cervical cancer

HPIP: a predictor of lymph node metastasis and poor survival in cervical cancer

Expression of HPIP in epithelial ovarian carcinoma: a clinicopathological study

Two decades of a protooncogene HPIP/PBXIP1: Uncovering the tale from germ cell to cancer

Contact Info

Product

Resources

About