The relationship between hyperuricemia and anemia and metabolic syndrome in Korean adults: The Korea National Health and Nutrition Examination Survey 2019

Seo, Ha Young; Mun, Chae Young; Park, Chea Yeon; Choi, Soo Bin; Hwang, Ji Hye; Lee, Jun Ho; Yoon, Hyun Ju

doi:10.1016/j.pcd.2022.11.007

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Serum uric acid was measured by the calorimetry method using a Hitachi Automatic Analyzer 7600-210 (Hitachi Medical Corporation, Tokyo, Japan). Hyperuricemia was defined as a serum uric acid level ≥7.0 mg/dL in men and ≥6.0 mg/dL in women [21].…”

Section: Study Parametersmentioning

confidence: 99%

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

Park,

Lim,

Lee

2024

JPM

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Upper airway collapse and apneas in obstructive sleep apnea (OSA) induce intermittent hypercapnia and hypoxia, eventually contributing to excessive uric acid production. This study aimed to evaluate the association between hyperuricemia and OSA in the general population via analysis of the eighth KNHANES dataset (2019–2021). OSA risk was identified via the STOP-Bang questionnaire, with a score ≥3 indicating high risk. Among 11,981 total participants, 4572 (38.2%) had a high OSA risk. Participants with a high OSA risk had higher uric acid levels compared to those with a low risk (5.5 ± 1.4 mg/dL vs. 4.8 ± 1.2 mg/dL, p < 0.001). Serum uric acid levels were positively correlated with STOP-Bang score (r: 0.317, p < 0.001). Multivariate analysis revealed that hyperuricemia was associated with a high OSA risk after adjusting for confounders (odds ratio: 1.30, 95%CI: 1.11–1.53, p = 0.001). Therefore, serum uric acid levels are significantly higher in those with a high OSA risk and correlate with the risk of OSA. Further, hyperuricemia is an independently associated risk factor for high OSA risk. More research is warranted to evaluate the long-term clinical outcomes of hyperuricemia in OSA and to determine whether treatment targeting hyperuricemia is effective in the clinical course of OSA.

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Section: Study Parametersmentioning

confidence: 99%

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

Park,

Lim,

Lee

2024

JPM

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The relationship between non-HDL cholesterol to HDL cholesterol ratio (NHHR) and anemia: A cross-sectional study of NHANES, 2009 to 2016

Cao,

Wang,

Zhu

et al. 2024

Medicine

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The non-HDL cholesterol to HDL cholesterol ratio (NHHR) is a newly developed metric that represents the ratio of non-HDL cholesterol to HDL cholesterol. Anemia is a prevalent public health concern affecting all age groups. Our purpose is to investigate the connection between NHHR and the prevalence of anemia, as well as to explore their potential interactions. A total of 17,019 participants were incorporated into this research. NHHR was calculated as the scale of non-HDL cholesterol to HDL cholesterol. According to WHO criteria, anemia at sea level is diagnosed with a hemoglobin level (g/dL) of <12 for women and <13 for men. This study utilized multivariate linear regression, threshold effect analysis, smooth curve fitting, multivariate logistic regression as well as subgroup analysis, to investigate the linkage between the NHHR and anemia. After complete adjustment, the model indicated a strong inverse relationship between NHHR and the prevalence of anemia (the odds ratio [OR] was 0.82 with a 95% confidence interval of 0.78–0.86), suggesting that an incremental increase in NHHR correlates with an 18% decrease in the prevalence of anemia. Segmenting NHHR into quartiles maintained this significant association. The prevalence of anemia was 51% lower among participants in the highest NHHR quartile compared to those in the lowest quartile, with an OR of 0.49 (95% CI: 0.41–0.59; P for trend < .0001). Subsequent analysis revealed a significant improvement in the threshold effect value to 4.28 for the potential relationship between NHHR and anemia. Subgroup analysis showed an inverse correlation in some subgroups. Alcohol consumption significantly affects the relationship between NHHR and anemia (interaction P < .05). Our study revealed that NHHR is inversely proportional to the prevalence of anemia in U.S. adults.

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The relationship between hyperuricemia and anemia and metabolic syndrome in Korean adults: The Korea National Health and Nutrition Examination Survey 2019

Cited by 2 publications

References 39 publications

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

The relationship between non-HDL cholesterol to HDL cholesterol ratio (NHHR) and anemia: A cross-sectional study of NHANES, 2009 to 2016

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