Introduction: Intercultural sensitivity and xenophobia levels of health education students can affect the care they give to the patient. It is important to know the level of intercultural sensitivity and xenophobia of students receiving health education and to determine the relationship between them. The purpose of the study was to examine the relationship between xenophobic attitudes and intercultural sensitivity among university students. Methods: This quantitative cross-sectional research was conducted in between January and June 2022 with health education students. The study conducted with health education students at Gumushane University and Agri Ibrahim Cecen University. Child Development, Nursing, Emergency Management Services/Technicians, Nutrition and Dietetics, Elderly care, Social services, Medical Laboratory Techniques, and Disabled Care studying at these universities were included in the study. Students who received health education and wanted to participate voluntarily in the study were included. Students aged 18 and over, studying in the health education department of the university, studying in the 1, 2, 3, 4th classes and volunteering to participate in the study were included in the study. The Introductory Information Form, the Xenophobia Scale, and the Intercultural Sensitivity Scale were used to collect the research data. Results: This study was conducted with 789 students. According to our study, a significant negative correlation was found between the students’ xenophobia scale and the intercultural sensitivity scale total score means ( p < .05). Intercultural sensitivity has a negative and significant effect on the level of xenophobia (β = -0.116; t (787) = -3.283, p = .001). A significant difference was found between the students’ Xenophobia Scale total score mean and gender, department, and grade ( p < .05) as was the case between Intercultural Sensitivity Scale total score mean and gender, department, grade, immigrant acquaintance, and foreign language knowledge (English language) level ( p < .05). Discussion: Intercultural sensitivity has a negative and significant effect on the level of xenophobia. It can negatively affect the level of caregiving of students receiving health education. It is thought that intercultural sensitivity will be developed by including course content in the curriculum to increase students’ intercultural effectiveness and awareness levels and to reduce xenophobic prejudices.