The Relationship Between Leukemia and
            <i>TP53</i>
            Gene Codon Arg72Pro Polymorphism: Analysis in a Multi-Ethnic Population

Drokow, Emmanuel Kwateng; Chen, Yuqing; Ahmed, Hafiz Abdul Waqas; Oppong, Timothy Bonney; Akpabla, Gloria Selorm; Pei, Yong; Kumah, Maame Awoyoe; Neku, Enyonam Adjoa; Sun, Kai

doi:10.2217/fon-2019-0792

Cited by 7 publications

(4 citation statements)

References 52 publications

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“…Frequent mutations and differential expression of TP53 in various types of malignant neoplasms emphasize the important role of p53 in carcinogenesis and tumor progression. Researches by Isakova et al, (2017), Diakite et al, (2020),Usenova (2018) and Drokow et al, (2020) confirmed the relationship between the Arg72Pro polymorphism in the TP53 gene and the risk of developing oncological diseases, in particular, acute lymphoblastic leukemia. In addition, Isakova et al, (2017) and Usenova (2018) demonstrate in their work the key role of this polymorphism specifically for people of Kyrgyz nationality.…”

Section: Discussionmentioning

confidence: 87%

The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

Usenova¹,

Akhunbaev²,

Tumanbaev

et al. 2023

Asian Pac J Cancer Prev

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Background:The relevance of the study lies in the fact that although the role of polymorphism of some genes that are responsible for cell apoptosis and deoxyribonucleic acid repair in the development of acute leukemia has already been established, its relationship with the gender of patients has not been studied enough. This study was aimed at studying the relationship between the Arg399Gln polymorphism in the XRCC1 deoxyribonucleic acid repair gene and the Arg72Pro polymorphism in the TP53 tumor suppressor gene encoding the p53 protein with the gender of children with acute leukemia. Material and methods: The study included 100 newly diagnosed pediatric patients of Kyrgyz nationality (69 boys and 31 girls), among which there were 77 patients with acute lymphoblastic leukemia, 22 patients with acute myeloblastic leukemia and 1 patient with a biphenotypic variant. Determination of polymorphisms was carried out by PCR-RFLP analysis or polymerase chain reaction followed by an analysis of restriction fragment length polymorphism. The interrelation of the results obtained with the patients' gender was assessed using statistical methods. Results:The study showed that there were no gender differences for all three genotypes of the Arg72Pro polymorphic marker of the tumor suppressor p53 (ТР53). Three Arg399Gln genotypes of the XRCC1 gene also did not depend on gender. However, with a separate analysis of each polymorphism, there was a tendency for a greater proportion of the Arg/Gln genotype in the group of boys compared to girls. The Gln/Gln polymorphism relationship requires further study due to insufficient data for analysis. Conclusion: The study has expanded the understanding of genetic changes and their relationship with gender, which have diagnostic, prognostic and therapeutic implications in acute leukemia. The conducted research of the relationship between individual phenotypes of acute lymphoblastic leukemia with risky polymorphisms in some genes contributes to the study of AL.

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Section: Discussionmentioning

confidence: 87%

The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

Usenova¹,

Akhunbaev²,

Tumanbaev

et al. 2023

Asian Pac J Cancer Prev

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“…Já nos Estados Unidos, um estudo realizado com pacientes com leucemia linfoblástica aguda, apontou que pacientes hispânicos possuem maior incidência dessa doença com taxa de sobrevida inferior, isso pode ser devido a um alelo de risco herdado de nativos americanos, porém há necessidade de novos estudos com um maior número de pessoas para melhor elucidação (QIAN et al, 2018). Drokow et al (2020), realizaram uma metanálise sobre o tema e concluíram que o polimorfismo Arg72Pro do TP53 está relacionado a um maior risco de desenvolvimento de leucemia nas populações indiana, chinesa, japonesa, africana e americana de acordo com as relações biológicas, mas reforçam ainda que a escassez de estudos dificulta o consenso sobre o assunto (DROKOW et al 2020).…”

Section: Resultsunclassified

Números De Casos E Mortalidade Por Leucemia Infantojuvenil No Brasil

Santos

Cardoso

2022

REMS

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Objetivo: O objetivo desse estudo foi analisar os dados sobre números de casos e mortalidade por leucemia infantojuvenil no Brasil por meio das bases de dados secundárias entre os anos de 2007 e 2017. Métodos: trata-se de um estudo observacional do tipo transversal retrospectivo em bancos de dados secundários de acesso público. Os dados foram coletados dos bancos de dados Globocan (IARC – International Agency for Research on Cancer) e da BasePop (INCA - Instituto Nacional de Câncer José Alencar Gomes da Silva), no período de novembro de 2019 a fevereiro de 2020, considerando os critérios de inclusão: crianças e adolescentes (zero a 19 anos de idade), todas as etnias e ambos os sexos; leucemias linfoides e mieloides, sendo elas agudas e crônicas; dados de casos (números absolutos) e mortalidade em todo o Brasil (incluindo estados, capitais e municípios). Por outro lado, excluiu-se adultos, idosos, gestantes e outros tipos de câncer infantojuvenil. Resultados: o número de casos de leucemia infantojuvenil no Brasil foi maior na faixa etária de 15 a 19 anos, no sexo masculino e etnia como “outros”. Já a mortalidade por leucemia infantojuvenil foi mais expressiva na faixa etária de 15 a 19 anos, no sexo masculino e nas regiões nordeste e sudeste. Conclusão: após análise de oito gráficos, foi observada a necessidade de mais estudos abordando esse tipo de análise, bem como a atualização melhor das bases de dados brasileiras para um melhor estudo e posicionamento.

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“…Table S1: Description of SNPs in the TP53 gene region with an MAF of at least 1%; Table S2: Literature review table for Pro47Ser; Table S3: Literature review table for Arg72Pro; Table S4: Allele frequencies of rs1042522 and rs1800371 SNPs in the TP53 gene region; Table S5: Association of TP53 SNPs with pathological upgrading from diagnostic biopsy to radical prostatectomy. References [13,37,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men

et al. 2023

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Growing evidence indicates the involvement of a genetic component in prostate cancer (CaP) susceptibility and clinical severity. Studies have reported the role of germline mutations and single nucleotide polymorphisms (SNPs) of TP53 as possible risk factors for cancer development. In this single institutional retrospective study, we identified common SNPs in the TP53 gene in AA and CA men and performed association analyses for functional TP53 SNPs with the clinico-pathological features of CaP. The SNP genotyping analysis of the final cohort of 308 men (212 AA; 95 CA) identified 74 SNPs in the TP53 region, with a minor allele frequency (MAF) of at least 1%. Two SNPs were non-synonymous in the exonic region of TP53: rs1800371 (Pro47Ser) and rs1042522 (Arg72Pro). The Pro47Ser variant had an MAF of 0.01 in AA but was not detected in CA. Arg72Pro was the most common SNP, with an MAF of 0.50 (0.41 in AA; 0.68 in CA). Arg72Pro was associated with a shorter time to biochemical recurrence (BCR) (p = 0.046; HR = 1.52). The study demonstrated ancestral differences in the allele frequencies of the TP53 Arg72Pro and Pro47Ser SNPs, providing a valuable framework for evaluating CaP disparities among AA and CA men.

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The Relationship Between Leukemia and TP53 Gene Codon Arg72Pro Polymorphism: Analysis in a Multi-Ethnic Population

Cited by 7 publications

References 52 publications

The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

Números De Casos E Mortalidade Por Leucemia Infantojuvenil No Brasil

Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men

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