The relationship between lipid risk score and new-onset hypertension in a prospective cohort study

Abstract

BackgroundDyslipidemia and hypertension are both important risk factors for atherosclerotic cardiovascular diseases. However, the relationship between dyslipidemia and incident hypertension remains to be elucidated comprehensively. The main purpose of this study was to construct the lipid risk score to explore the risk prediction effect of integrated lipid indices on new-onset hypertension.MethodsThis prospective cohort study with 2116 non-hypertensive subjects was conducted from 2009 to 2020. New hypertension events during the follow-up period were recorded and verified. The lipid risk score was calculated by summing coded total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol weighted with corresponding effect sizes. Cox regression analysis was used to estimate the association between the lipid risk score or lipid indices and incident hypertension in the subgroup of age (< 55 and≥ 55 years at baseline).ResultsAfter a median of 10.75-year follow-up, 637 incident hypertension cases were identified. The restricted cubic spline showed that the lipid risk score had a positive linear correlation with hypertension (P< 0.001). Among people< 55 years, with every increase of 0.94 in lipid risk score, the risk of hypertension increased by 37% (adjusted HR [95%CI]: 1.369 [1.164-1.610]). This association was not modified by overweight or obesity.ConclusionsThe integrated lipid risk score, independent of traditional risk factors, has a significantly predictive effect on hypertension in people younger than 55 years. This finding may aid in identifying high-risk individuals for hypertension, as well as facilitating early intervention and management to reduce adverse cardiovascular events. Comprehensive lipid management should be attached importance in the prevention and control of hypertension.

Association of lipid accumulation product and the risk of type 2 diabetes; a cross sectional population-based study

“…Visceral adiposity index (VAI) and waist/height ratio (WHtR) [20,40]. Similarly, the present study also showed that LAP (AUC = 0.66) has higher diagnostic value than WC (AUC = 0.60) and TG (AUC = 0.64).…”

“…The association between LAP and T2DM has been found to be positive in several demographic and ethnic subgroups. Brie y, in the Japanese population, high LAP have been shown to increase the risk of T2DM by 76% over time [20]. Similar results have been reported in adults Chinese and middle-aged Koreans [27,28].…”

“…LAP is a combined index of WC and TG levels, used to assess visceral fat. Research conducted in some populations suggests that the LAP index is a reliable predictor for chronic conditions such as metabolic syndrome, CVD, hypertension, and T2DM [17][18][19][20]. It appears that there has not been a thorough study in Iran to examine the effectiveness of LAP in predicting T2DM.…”

Association and Risk Factors for Hypertension and Dyslipidemia in Young Adults from Poland

“…According to the study by Sesso et al, the baseline lipid levels, especially HDL-C and non-HDL-C, and the TC/HDL-C ratio are associated with an increased risk of hypertension [9]. In the prevention and control of hypertension, attention should be paid to the control of lipid metabolism [35].…”

Isorhynchophylline improves lipid metabolism disorder by mediating a circadian rhythm gene Bmal1 in spontaneously hypertensive rat

“…Lipidomics is widely used in biomedical research, especially in evaluating the lipid metabolism status of diseases (Yang & Han, 2016). As compared to traditional lipidomics, the application of diurnal lipidomics not only reflects the changes in metabolites in diffident groups in vivo but also comprehensively characterizes the 24-h changes in metabolites in vivo (Xie et al, 2022). Lipid circadian rhythm fluctuation is a normal physiological phenomenon, showing the differences in circadian metabolic activity (Poggiogalle et al, 2018).…”