The relationship between major depressive disorders and glucose parameters: A cross-sectional study in Chinese population

Abstract

Background. Depressive symptoms have been linked with insulin resistance in middle-aged and elderly populations. A strong relationship between peripheral insulin resistance and glucose homeostasis imbalance has been well established in previous studies. The role of serum fructosamine and fasting blood glucose (FBG) in elevating glucose homeostasis has been documented in the literature.Objectives. The aim of the study was to examine the association of serum fructosamine and FBG with major depressive disorder (MDD). Material and methods.The study analyzed the clinical characteristics and biochemical parameters of 305 patients with MDD and 312 healthy individuals.Results. Serum concentrations of lipoprotein-cholesterol (HDL-C), total protein (TP) and creatinine (Cr) were found to be significantly different between the two groups. Serum fructosamine and fasting blood glucose (FBG) concentrations were high in patients with MDD compared with healthy individuals (2.3 ± 0.26 vs. 2. 1 ± 0.27, p = 0.018; 4.7 ± 0.45 vs. 4.5 ± 0.45, p < 0.001). The levels of serum fructosamine and FBG were also significantly higher in patients with MDD when all participants were stratified by gender. Age was found to be positively correlated with FBG, serum fructosamine and Cr (r = 0.203, p < 0.001; r = 0. 129, p = 0.025; r = 0. 129, p = 0.024), and negatively correlated with TP (r = -0. 114, p = 0.047) in patients with MDD. However, there were no correlations between age and FBG, serum fructosamine or Cr in the healthy controls. In a multivariate logistic regression analysis, increased serum fructosamine and FBG concentrations were positively associated with MDD independently of age and gender, after adjustment for age and potential confounding factors (OR = 6.313, CI95 %:2.953-13.393, p < 0.001; OR = 2.251, CI95 %: 1.464-3.462, p < 0.001). Conclusions.The study results suggest that increased serum fructosamine and FBG concentrations are associated with depressive conditions, which may influence glucose metabolism and impair glucose homeostasis in patients with MDD.

Association of depressive disorder with biochemical and anthropometric indices in adult men and women

“…In a meta-analysis, Wei et al 35 documented that subjects with first-episode depression were more likely to have higher triglycerides and lower HDL-C than healthy subjects. Our findings were consistent with the results of previous studies, suggesting an association with triglycerides 31 , 32 , 35 , hematocrit 38 , BUN 33 , and glucose 33 , 43 . Additionally, our findings were similar to the results of previous studies indicating no associations with WBCs 37 , 41 or with hemoglobin 41 .…”

“…To date, many studies have been performed to reveal association between biochemical indices and depression disorder, but the associations remain unclear because the results of previous studies are contradictory: significant associations were found with triglyceride level 31 , 32 , 35 as well as no association 33 , 41 , associations were found with total cholesterol level 41 as well as no association 31 , 33 , associations were found with HDL-C level 33 – 36 as well as no association 31 , 41 , associations were found with WBC 37 as well as no association 37 , 41 , associations were found with RBC 29 , 37 , 38 as well as no association 41 , associations were found with hemoglobin levels in both genders 38 or only in men 37 and no association was found as well 41 , associations were found with hematocrit level 38 as well as no association 37 , 41 , associations were found with creatinine level 33 as well as no association 41 , and significant associations were found with glucose level 33 , 43 as well as no association 29 , 41 . For example, Tyrovolas et al .…”

“…They argued that depression was not associated with total cholesterol or triglyceride levels. Another study by Peng et al 43 revealed that fasting blood glucose concentration was associated with major depression in the Chinese population, irrespective of age, sex, and other potential confounders. A study by Van Reedt Dortland et al 44 reported that patients with current depression had higher triglyceride levels and lower HDL-C than patients with remitted depression and control subjects in Dutch adults, but these associations disappeared after adjustment for alcohol consumption, smoking, BMI, and education level.…”

Prevalence and predisposing factors of depressive symptoms in patients with stable coronary artery disease: a cross-sectional single-center study

“…In this study, decreased Cr levels are risk factors for the onset of moderate/severe depressive symptoms, which are consistent with previous findings [28], which might be related to anorexia nervosa. Serum Cr has been known to be produced from both exogenous and endogenous processes.…”

Depressive symptoms and metabolic syndrome components among older Chinese adults

“…Similar associations were found in a longitudinal study with British elders [24]. In addition, a study of Chinese population also demonstrated that FPG concentration was positively associated with the prevalence of depressive symptoms [25]. Shared pathophysiological mechanisms may exist in depressive symptoms and diabetes such as visceral obesity [26], decreased adiponectin level [27] and cortisol dysregulation from the hypothalamic-pituitaryadrenal axis [28].…”