The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia

Çakmak, Burcu Dinçgez; Dündar, Betül; Açıkgöz, Aydan; Özgen, Gülten; Çift, Tayfur; Ahmedian, Robab; Altekin, Yasin

doi:10.1515/jpm-2017-0053

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…39 Moreover, low circulating adropin levels have been associated not only with high BMI, insulin resistance, endothelial dysfunction, and coronary atherosclerosis but also with severe PE. 70,71 Thus, the incontrovertible link between obesity and PE should provide additional impetus to implement public health measures and educational programs to tackle the current epidemic. In pregnancy, the focus should be on strict prevention of excessive GWG-as advocated by Hamlin in 1952.…”

Section: Obesity and Excessive Gestational Weight Gainmentioning

confidence: 99%

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Adolescent Preeclampsia: Pathological Drivers and Clinical Prevention

et al. 2019

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Preeclampsia is an important cause of maternal and perinatal morbidity, especially in first-time pregnant adolescent women. Although prevention of preeclampsia has been attempted for many decades, effective intervention can only be achieved upon the full elucidation of the risk factors and mechanisms of disease. As the pathogenesis of preeclampsia during adolescence may differ from that in older women, preventive interventions should be tailored accordingly. During adolescence, 4 putative drivers of preeclampsia can be identified. First, uterine immaturity in very young teenagers is likely a major cause of defective deep placentation and adverse reproductive outcome, underscoring the importance of educational programs and public health initiatives focused on teen pregnancy prevention. Second, the association between adolescent obesity and preeclampsia merits further studies on the benefits of weight loss and dietary interventions to improve pregnancy outcome. Third, there is a need for greater awareness of the link between cardiovascular risk factors in young women and early-onset preeclampsia associated with atherosclerosis of the uteroplacental arteries. Finally, infrequent menstruations may prolong uterine immaturity because of lack of "menstrual preconditioning." This risk factor may be amenable to pharmacological/hormonal preconditioning prior to conception.

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Section: Obesity and Excessive Gestational Weight Gainmentioning

confidence: 99%

Section: Extrinsic Factors In Adolescent Pementioning

confidence: 99%

Adolescent Preeclampsia: Pathological Drivers and Clinical Prevention

et al. 2019

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“…This review summarizes the findings of 47 studies concerning the adipokine levels in at least two different biological fluids of maternal–infant dyads and includes all possible different sets of biological fluids: maternal and cord plasma, neonate/infant plasma, milk, and placental tissues, for both physiological and disturbed pregnancy and lactation. The current state of knowledge clearly indicates the possible impact of the maternal hyperglycemic status [ 113 , 118 , 131 , 139 , 143 , 146 , 148 , 151 ], preeclampsia [ 77 , 123 , 124 , 134 , 152 ], preterm delivery [ 119 ], and fetal growth restrictions [ 115 , 122 ] on the quantitative profile of adipokines important for energy homeostasis, the regulations of metabolism, and fat tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The analysis concerning the adropin level in maternal–infant dyads is not comprehensive and includes five reports which present the data for two different biological fluids only [ 115 , 130 , 133 , 151 , 152 ] ( Table 3 ).…”

Section: Adipokines In Maternal–infant Dyadmentioning

confidence: 99%

“…On the other hand, Cakmak and coworkers [ 152 ] analyzed the maternal and cord adropin levels in relation to preeclampsia for both the maternal and cord samples, and significantly lower adropin levels (71.2 ± 22.2 ng/L and 92.4 ng/L, respectively) for the preeclampsia group were noted in comparison to the normal group (100.8 ± 27.0 ng/L for maternal and 106.2 ng/L for cord, respectively). Moreover, the cord adropin levels were weakly correlated with the gestational age at delivery (r = 0.3) and the neonatal birth weight (r = 0.3) [ 152 ].…”

Section: Adipokines In Maternal–infant Dyadmentioning

confidence: 99%

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The Mother–Child Dyad Adipokine Pattern: A Review of Current Knowledge

Lis-Kuberka,

Pupek,

Orczyk-Pawiłowicz

2023

Nutrients

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An important role in the network of interconnections between the mother and child is played by adipokines, which are adipose tissue hormones engaged in the regulation of metabolism. Alternations of maternal adipokines translate to the worsening of maternal insulin resistance as well as metabolic stress, altered placenta functions, and fetal development, which finally contribute to long-term metabolic unfavorable conditions. This paper is the first to summarize the current state of knowledge concerning the concentrations of individual adipokines in different biological fluids of maternal and cord plasma, newborn/infant plasma, milk, and the placenta, where it highlights the impact of adverse perinatal risk factors, including gestational diabetes mellitus, preeclampsia, intrauterine growth restriction, preterm delivery, and maternal obesity on the adipokine patterns in maternal–infant dyads. The importance of adipokine measurement and relationships in biological fluids during pregnancy and lactation is crucial for public health in the area of prevention of most diet-related metabolic diseases. The review highlights the huge knowledge gap in the field of hormones participating in the energy homeostasis and metabolic pathways during perinatal and postnatal periods in the mother–child dyad. An in-depth characterization is needed to confirm if the adverse outcomes of early developmental programming might be modulated via maternal lifestyle intervention.

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Long-term chronic caloric restriction alters miRNA profiles in the brain of ageing mice

et al. 2021

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Calorie restriction (CR) has been shown to be one of the most effective methods in alleviating the effects of ageing and age-related diseases such as increasing longevity and preventing dementia, and Alzheimer’s Disease. Although the protective effects of CR have been reported, the exact molecular mechanism still needs to be clarified. This study aims to determine differentially expressed (DE) miRNAs and altered gene pathways due to long-term chronic (CCR) and intermittent (ICR) CR in the brain of mice to understand the preventive roles of miRNAs in long-term CR. Ten weeks old mice were enrolled into three different dietary groups; ad-libitum, CCR or ICR, and fed until 82 weeks old mice. miRNAs were analyzed using GeneChip 4.1 microarray and the target of DE miRNAs was determined using miRNA target databases. Out of a total 3,163 analyzed miRNAs, 55 of them were differentially expressed either by different CR protocols or by ageing. Brain samples from the CCR group had increased expression levels of mmu-miR-713 while decreasing expression levels of mmu-miR-184-3p and mmu-miR-351-5p compared to the other dietary groups. Also, current results indicated that CCR showed better preventive effects than that of ICR. Thus, CCR may perform its protective effects by modulating these specific miRNAs since they are shown to play roles in neurogenesis, chromatin, and histone regulation. In conclusion, these three miRNAs could be potential targets for neurodegenerative and ageing-related diseases and may play important roles in the protective effects of CR in the brain.

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The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia

Abstract: The present study is the first to demonstrate a significant association between maternal and umbilical adropin levels and the presence and severity of preeclampsia. Adropin might be a useful parameter for predicting the presence and severity of preeclampsia.

Cited by 8 publications

References 26 publications

Adolescent Preeclampsia: Pathological Drivers and Clinical Prevention

Adolescent Preeclampsia: Pathological Drivers and Clinical Prevention

The Mother–Child Dyad Adipokine Pattern: A Review of Current Knowledge

Long-term chronic caloric restriction alters miRNA profiles in the brain of ageing mice

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