The Relationship between Mercury from Dental Amalgam and Mental Health

Siblerud, Robert L.

doi:10.1176/appi.psychotherapy.1989.43.4.575

Cited by 34 publications

(15 citation statements)

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“…The only study showing effects involved a young sample (mean age 22.4 and 23.3 years respectively), where the control group had never had any exposure to amalgam [94]. There was a positive correlation between number of fillings and mercury excretion in urine and hair, as well as with forgetfulness and symptoms.…”

Section: Health Effects Of Dental Amalgamsmentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

148

113

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Abstract. Mercury is one of the most toxic substances known to humans. It has been introduced into the human environment and has also been widely used in medicine. Since circumstantial evidence exists that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by inorganic mercury, we conducted a systematic review using a comprehensive search strategy. Studies were screened according to a pre-defined protocol. Two reviewers extracted relevant data independent of each other. One thousand and forty one references were scrutinized, and 106 studies fulfilled the inclusion criteria. Most studies were case control or comparative cohort studies. Thirty-two studies, out of 40 testing memory in individuals exposed to inorganic mercury, found significant memory deficits. Some autopsy studies found increased mercury levels in brain tissues of AD patients. Measurements of mercury levels in blood, urine, hair, nails, and cerebrospinal fluid were inconsistent. In vitro models showed that inorganic mercury reproduces all pathological changes seen in AD, and in animal models inorganic mercury produced changes that are similar to those seen in AD. Its high affinity for selenium and selenoproteins suggests that inorganic mercury may promote neurodegenerative disorders via disruption of redox regulation. Inorganic mercury may play a role as a co-factor in the development of AD. It may also increase the pathological influence of other metals. Our mechanistic model describes potential causal pathways. As the single most effective public health primary preventive measure, industrial, and medical usage of mercury should be eliminated as soon as possible.

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Section: Health Effects Of Dental Amalgamsmentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

148

113

View full text Add to dashboard Cite

show abstract

“…The safety of dental amalgam has been challenged with claims that mercury released from amalgam could produce mercury poisoning or it could be responsible for different symptoms of impaired health or for chronic conditions such as multiple sclerosis (MS) [1][2][3][4]. A correlation has been reported between the prevalence of MS and dental caries and a linear relationship between mortality rates from MS and the number of decayed, missing and filled teeth [5].…”

Section: Introductionmentioning

confidence: 99%

Multiple Sclerosis and Dental Amalgam: Case-Control Study in Ferrara, Italy

2001

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Dental amalgam fillings containing mercury have been suggested as a possible risk factor for multiple sclerosis (MS). In the context of a wider program of investigation into environmental risk factors and MS, we conducted a case-control comparison to investigate the alleged association between MS, dental caries, and amalgam fillings. We included 132 MS patients with onset during the last 16 years and 423 controls, matched to cases for sex, age and residence. Data were collected by a personal interview conducted by trained doctors. Cases and controls gave informed consent. Although we report a trend toward a higher number of dental fillings in cases than controls, odds ratios for subjects with exposures of different duration and with different numbers of amalgam fillings were not statistically significant. This case-control study failed to demonstrate an association between either the number of dental amalgam fillings or the duration of exposure to mercury amalgam and MS.

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“…Siblerud 16 compared oral health parameters of 50 subjects with amalgam fillings with those of 51 subjects without amalgams. Amalgam subjects displayed more gingival bleeding, periodontal disease, metallic taste, and foul breath than did the amalgam-free group.…”

Section: Clinical Side Effects To Dental Amalgammentioning

confidence: 99%