The relationship between migraine and rosacea: Systematic review and meta-analysis

Christensen, Casper Emil; Andersen, Frederikke Schelde; Wienholtz, Nita Katarina Frifelt; Egeberg, Alexander; Thyssen, Jacob P.; Ashina, Messoud

doi:10.1177/0333102417731777

Cited by 31 publications

(36 citation statements)

References 96 publications

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“…A population-based study conducted in the United Kingdom observed a significant association between rosacea and migraine in females (OR: 1.22; 95% CI: 1.16–1.29) [ 10 ]. The most recent systematic review and meta-analysis also reported the possible association between the development of migraine and rosacea [ 35 ].…”

Section: The Risk Of Neurologic Diseases In Rosaceamentioning

confidence: 99%

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Woo

Han

Kim

et al. 2020

IJMS

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Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea.

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Section: The Risk Of Neurologic Diseases In Rosaceamentioning

confidence: 99%

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Woo

Han

Kim

et al. 2020

IJMS

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“…The connection between migraine and sleep disorders has been recognized [35,36]. However, the connection of migraine and rosacea and other skin disorders is only beginning to emerge, and studies have mainly focused on the increase in odds ratio of migraine in patients with rosacea, not the other way around [37,38]. There are potential pathophysiological overlaps with migraine and neuroendocrineimmune-related skin disorders, in which also calcitonin gene related peptide (CGRP) has been suggested to play a role.…”

Section: Increased Comorbidity Based On Phenotypic Disease Networkmentioning

confidence: 99%

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

Korolainen¹,

Tuominen²,

Kurki

et al. 2020

J Headache Pain

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Background: Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age using real world data collected as a part of routine clinical practice. Methods: Electronic medical records (EMR) of patients with migraine (n = 17,623) and age-and gender matched controls (n = 17,623) were included in this retrospective analysis. EMRs were assessed for the prevalence of ICD-10 codes, those with at least two significant phi correlations, and a prevalence >2.5% in migraine patients were included to phenotypic disease networks (PDN) for further analysis. An automatic subnetwork detection algorithm was applied in order to cluster the diagnoses within the PDNs. The diagnosis-wise connectivity based on the PDNs was compared between migraine patients and controls to assess differences in morbidity patterns. Results: The mean number of diagnoses per patient was increased 1.7-fold in migraine compared to controls. Altogether 1337 different ICD-10 codes were detected in EMRs of migraine patients. Monodiagnosis was present in 1% and 13%, and the median number of diagnoses was 12 and 6 in migraine patients and controls. The number of significant phi-correlations was 2.3-fold increased, and cluster analysis showed more clusters in those with migraine vs. controls (9 vs. 6). For migraine, the PDN was larger and denser and exhibited one large cluster containing fatigue, respiratory, sympathetic nervous system, gastrointestinal, infection, mental and mood disorder diagnoses. Migraine patients were more likely affected by multiple conditions compared to controls, even if no notable differences in morbidity patterns were identified through connectivity measures. Frequencies of ICD-10 codes on a three character and block level were increased across the whole diagnostic spectrum in migraine. Conclusions: Migraine was associated with an increased multimorbidity, evidenced by multiple different approaches in the study. A systematic increase in the morbidity across the whole spectrum of ICD-10 coded diagnoses, and when interpreting PDNs, were detected in migraine patients. However, no specific diagnoses explained the morbidity. The results reflect clinical praxis, but also undoubtedly, the pathophysiological phenotypes related to migraine, and emphasize the importance of better understanding migraine-related morbidity.

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“…Migraine has repeatedly been associated with rosacea. 1 Both are chronic inflammatory conditions with relapsing episodes of headache for migraine, and redness/flushing and/ or papules/pustules for rosacea. Relapses may be triggered by various endogenous and/or exogenous factors such as different foods and drinks, exercise, sun/UV exposure, heat and stress.…”

Section: Introductionmentioning

confidence: 99%

“…10 Common demography, triggers and associated neuropeptides suggest a shared pathophysiological pathway. 1 Despite overwhelming evidence of a connection between migraine and rosacea, [15][16][17][18][19][20] underdiagnosis in both disorders must be considered as a confounder in previous research, and a systematic approach is therefore needed to confirm this connection and to better characterise exact overlap between these diseases. Establishment of prospective patient cohorts with a physiciandiagnosis of either migraine or rosacea will help confirm this connection and uncover possible risk factors and comorbidities in both.…”

Section: Introductionmentioning

confidence: 99%

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Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO)

et al. 2020

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PurposeMigraine has consistently been connected with rosacea. Commonalities in epidemiology, trigger factors and associated neuropeptides support shared aetiology and pathophysiological pathways, though underlying mechanisms remain unclear. We established two cohorts of patients diagnosed with either migraine and/or rosacea. All patients were phenotyped in regard to migraine and rosacea. In this article, we describe the baseline parameters of the cohorts. In the future, we expect that these cohorts will help uncover potential disease overlaps and allow for prolonged follow-up through national Danish health registers.ParticipantsCOpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO) are prospective cohorts based in the Capital region of Denmark. Participants for COROCO were recruited primarily through two tertiary dermatology clinics in Copenhagen, Denmark and patients for COMICO were recruited through a tertiary neurology clinic in Copenhagen, Denmark.Findings to dateCOROCO: 67.7% women (median age 51 years (interquartile range (IQR) 43.0–61.0)). Family history of migraine: 44.3%. Family history of rosacea: 45%. There were 13% who currently smoked, and 36.6% were former smokers. Regular intake of alcohol was present in 79.3% (median 4 items/week (IQR 1.0–9.0)). Median body mass index (BMI): 25.7 (IQR 23.1–29.0). Median Dermatology Life Quality Index (DLQI): 2 (IQR 1–5).COMICO: 88.5% women (median age 41 years (IQR 29.5–51.0)). Family history of migraine: 73.4%. Family history of rosacea: 18.4%. There were 17.1% who currently smoked, and 26.0% former smokers. Regular intake of alcohol was present in 62.2% (median intake: 2 item/week (IQR 1.0–3.0)). Median BMI was 24.6 (IQR 21.5–28.2). Median DLQI was 1 (IQR 0–2).Future plansCOROCO and COMICO serve as strong data sources that will be used for future studies on rosacea and migraine with focus on risk factors, occurrence, treatment, natural history, complications, comorbidities and prognosis.Trial registration numberClinicalTrials.gov Registry (NCT03872050).

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The relationship between migraine and rosacea: Systematic review and meta-analysis

Cited by 31 publications

References 96 publications

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO)

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