The relationship between multimorbidity and suicidal ideation: A meta-analysis

Xiong, Feiyang; Wang, Li; Shen, Lianlian; Guo, Wenhui; Li, Shixue; Guan, Qiangdong

doi:10.1016/j.jpsychores.2020.110257

Cited by 17 publications

(14 citation statements)

References 60 publications

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“…On the association between obesity and multimorbidity, our results showed that individuals with obesity and physical multimorbidity exhibit three times higher odds of having suicidal ideation than participants without multimorbidity, and this association was replicable across cycles. This solidifies previous findings (Amiri and Behnezhad, 2018;Xiong et al, 2020) showing physical and/or mental multimorbidity as contributor to the development of suicidal ideation. However, given the root of multimorbidity was not assessed in our study, no direct association between obesity and the different health conditions evaluated can be drawn.…”

Section: Discussionsupporting

confidence: 91%

Association between physical multimorbidity and suicidal ideation in young adults with obesity

Mattar¹,

Chauvin²,

Marleau³

et al. 2021

Preprint

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Obesity is considered as one of the entrance point of multimorbidity and has an impact on physical and mental health. While some evidence points out to a possible relationship between obesity, multimorbidity and suicidal spectrum, little provide a direct association. Thus, the aim of the present study was to examine the co-occurring effect of both multimorbidity and obesity on suicidal ideation. Methods A cross-sectional analysis of the Canadian Community Health Survey data was conducted. A weighted sample of young adults (18 to 30 years-old) with obesity, from the province of Quebec, of the 2005 (n=394) and 2015–2016 (n=295) cycles were investigated independently. Multimorbidity, suicidal ideation, and health behaviours were self-reported. Results The prevalence of physical multimorbidity was 15% in 2005 and 18% in 2015–2016. Adjusted logistic regressions showed an association between multimorbidity and suicidal ideation (2005: OR 3.59, 95% CI 1.89-6.81; 2015–2016: OR 3.72, 95% CI 1.88-7.36). Among covariates, the significant association of sex (OR 1.98; 95% CI 1.16-3.37) and educational status (OR 3.27; 95% CI 1.49-7.18) in the 2005 cycle, were not replicated in the 2015–2016 cycle (education: OR 0.93; 95% CI 0.46-1.87; sex (OR 0.90; 95% CI 0.48-1.69). Finally, our results suggest no consistent association between health behaviours and suicidal ideation.Conclusion Multimorbidity seems to be associated with suicidal ideation among those with obesity. Attention should be given to multimorbidity management within obesity-related interventions for young people, as the development of suicidal ideation may also be prevented.

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Section: Discussionsupporting

confidence: 91%

Association between physical multimorbidity and suicidal ideation in young adults with obesity

Mattar¹,

Chauvin²,

Marleau³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…These findings are in line with previous studies where sensory loss was associated with suicidal ideation, and gastrointestinal disease was linked to higher rates of suicide after hospitalization [ 42 , 43 ]. A recent meta-analysis concluded that individuals with physical multimorbidity were more likely to present current and future suicidal ideation [ 44 ], as well as higher suicide risk, especially when depression was comorbid [ 45 ]. In our study, the node of suicidal thoughts shared high connectivity with core depressive symptoms, such as sadness and inability to feel .…”

Section: Discussionmentioning

confidence: 99%

Bridging late-life depression and chronic somatic diseases: a network analysis

et al. 2021

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The clinical presentation of late-life depression is highly heterogeneous and likely influenced by the co-presence of somatic diseases. Using a network approach, this study aims to explore how depressive symptoms are interconnected with each other, as well as with different measures of somatic disease burden in older adults. We examined cross-sectional data on 2860 individuals aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen, Stockholm. The severity of sixteen depressive symptoms was clinically assessed with the Comprehensive Psychopathological Rating Scale. We combined data from individual clinical assessment and health-registers to construct eight system-specific disease clusters (cardiovascular, neurological, gastrointestinal, metabolic, musculoskeletal, respiratory, sensory, and unclassified), along with a measure of overall somatic burden. The interconnection among depressive symptoms, and with disease clusters was explored through networks based on Spearman partial correlations. Bridge centrality index and network loadings were employed to identify depressive symptoms directly connecting disease clusters and depression. Sadness, pessimism, anxiety, and suicidal thoughts were the most interconnected symptoms of the depression network, while somatic symptoms of depression were less interconnected. In the network integrating depressive symptoms with disease clusters, suicidal thoughts, reduced appetite, and cognitive difficulties constituted the most consistent bridge connections. The same bridge symptoms emerged when considering an overall measure of somatic disease burden. Suicidal thoughts, reduced appetite, and cognitive difficulties may play a key role in the interconnection between late-life depression and somatic diseases. If confirmed in longitudinal studies, these bridging symptoms could constitute potential targets in the prevention of late-life depression.

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“…What's more, unwholesome lifestyles containing poor diets, tobacco and alcohol abuse and lack of physical activity may enhance the risk of somatic disease such as obesity, hypertension, metabolic syndrome and cardiovascular diseases [53]. Individuals suffering from somatic multi-morbidity are more prone to have suicidal thoughts [54], which is likely related to damage for body system that controls the stress response, immunologic function and in ammation [55].…”

Section: Discussionmentioning

confidence: 99%

Bridge connection between depression and anxiety symptoms and lifestyles in Chinese residents from a network perspective

Wang

Gao³

et al. 2022

Preprint

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Purpose As lifestyle behaviors are components of the culture of mental health treatment settings, we examined bridge connection between depression and anxiety symptoms and lifestyles from a network perspective using a population-based study.Methods A provincial representative sample of 13,768 inhabitants from the Guangdong Sleep and Psychosomatic Health Survey was face-to-face interviewed using standardized assessment tools. Expected influence was used to identify central symptoms. The interconnection between depression and anxiety symptoms, and bridge connectivity linking depression-anxiety symptoms and lifestyle factors was evaluated using bridge centrality index. A case dropping bootstrap procedure was employed to network stability and sensibility analyses. Results In depression-anxiety symptoms network,fatigue or little energy has the highest expected influence, followed by uncontrollable worry, trouble relaxing and sad mood. Surrounding nodes of each node explained a mean 57.63% of the variance. In the network integrating depression-anxiety symptoms with lifestyle factors, suicidal thoughts were identified as collective bridging symptoms connecting lifestyle variables. And irritability and guilt also indicated the highest connectivity with lifestyles. All networks had high stability and accuracy. Conclusion These emphasized core and bridge symptoms were latent targets to prevent and intervene comorbid depression and anxiety. Targeting interventions aiming at specific lifestyle behaviors may be crucial to develop efficient and purposeful treatment strategies for clinical practitioners.

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The relationship between multimorbidity and suicidal ideation: A meta-analysis

Cited by 17 publications

References 60 publications

Association between physical multimorbidity and suicidal ideation in young adults with obesity

Association between physical multimorbidity and suicidal ideation in young adults with obesity

Bridging late-life depression and chronic somatic diseases: a network analysis

Bridge connection between depression and anxiety symptoms and lifestyles in Chinese residents from a network perspective

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