Objectives: To evaluate the association between oral health-related quality of life and oral healthrelated self-efficacy in high school students. Methods: A questionnaire-based survey was conducted among high school students in Daegu, South Korea from November to December 2015, and the final data of 432 students were analyzed. Results: Analysis of oral health-related self-efficacy in terms of general characteristics showed that both grade and income were significant factors (P<0.01). Furthermore, analysis of oral health-related quality of life in terms of general characteristics showed that academic achievement, father's educational level, and academic stress were significant factors (P<0.05). Correlation analyses of oral health-related quality of life with oral health-related self-efficacy revealed positive correlations with tooth brushing and ordinary oral health behavior. Regression analysis of oral health-related quality of life showed that father's educational level, oral health-related self-efficacy, academic stress, and academic achievement were influencing factors. Conclusions: These results indicate that oral health-related self-efficacy may play a significant role in oral health-related quality of life.