The relationship between osteoprotegerin gene polymorphisms and bone mineral density in Chinese postmenopausal women

Wang, Qingfu; Chen, Zhuang-hong; Huang, Yong; Li, Qi; Zhu, Lixin; Cai, Xianhua; He, Guochao; Xie, Yonghui; Liu, Qin

doi:10.1016/j.intimp.2013.06.031

Cited by 11 publications

(10 citation statements)

References 40 publications

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“…Data from the literature indicates that OPG is considered to be one of the most important candidate genes for influencing the pathogenesis of osteopathy (Song et al, 2013;Wang et al, 2013;Guo et al, 2014) particularly in postmenopausal women. It is characterized by a reduction in BMD.…”

Section: Introductionmentioning

confidence: 99%

“…It is characterized by a reduction in BMD. As an active component of this system, therefore, polymorphisms in the OPG gene might influence bone metabolism and BMD (Wang et al, 2013;Guo et al, 2014) neck hip and total hip was determined by dual-energy X-ray absorptiometry (DEXA). Although several studies have investigated the association of OPG single nucleotide polymorphisms (SNPs) such as 163A>G, 1181G>C, 245T>G, and 950T>C with BMD and bone disorders (Feng et al, 2012;Liu et al, 2013;Wang et al, 2013;Yu et al, 2013;Guo et al, 2014) which is characterized by a decrease in BMD, the relationship between the 1181G>C and 163A>G SNPs of the OPG gene and T1DM and BMD has not yet been evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

Loureiro

Ururahy

Souza

et al. 2018

Braz. J. Pharm. Sci.

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The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was performed for 1181G>C and 163A>G OPG polymorphisms by allelic discrimination in 119 patients with T1DM and 161 normoglycemic (NG) individuals, aged 6 to 20 years old. Glycemic control, serum parameters of bone metabolism and BMD were evaluated. T1DM patients showed low BMD, poor glycemic control and decreased total calcium values when compared to controls (p < 0.05). For all the polymorphisms studied, the genotype and allele frequencies in patients with T1DM were not significantly different from the controls. In patients with T1DM, carriers of OPG 1181CC showed higher concentrations of ionized calcium compared to patients with GG+GC genotypes. These results suggest that low BMD is associated with poor glycemic control in T1DM. Despite the lack of a detected association between OPG polymorphisms and BMD in these patients, the increased ionized calcium in those carrying OPG 1181CC suggests a possible increase in osteoclastogenesis, a conclusion that may be supported by the lower BMD observed in these subjects.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

Loureiro

Ururahy

Souza

et al. 2018

Braz. J. Pharm. Sci.

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“…Recent studies have attributed a decisive role to the RANK/RANKL/OPG system in regulating bone metabolism and osteoclastogenesis [3,4]. In recent years, some foreign study found, OPG/RANK/RANKL system of single-nucleotide polymorphisms (SNPs) was related with bone metabolism updates, bone erosion and BMD, explored the associations with osteoporosis [5,6], cardiovascular disease [7], tumor [8], ischemic stroke [9] but there is few relevant research on the association with RA.…”

Section: Introductionmentioning

confidence: 99%

Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han

Cai

Wang

et al. 2015

Immunology Letters

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“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License disorder with genetic influence accounting for up to 70% of individual variance in BMD (Jouanny et al, 1995). It was reported that, in postmenopausal state, the BMD was affected by a series of bone mass modulating factors, such as vitamin D receptor, estrogen receptor, and osteoprotegerin etc., and that polymorphisms in genes encoding these factors were significantly associated with osteoporosis risk (Horst-Sikorska et al, 2013;Gennari et al, 2005;Arko et al, 2005;Wang et al, 2013). Therefore, to define certain candidate genes responsible for regulation of bone mass and susceptibility to osteoporosis may be a beneficial approach for better understanding of the etiology and mechanisms of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of glucagon-like peptide-1 receptor gene (rs1042044) is associated with bone mineral density in Chinese Han postmenopausal women

Fu¹,

Xu²,

Zhang³

et al. 2015

Afr. J. Biotechnol.

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Previous investigations indicated that glucagon-like peptide-1 (GLP-1) played important roles in bone turnover via GLP-1 receptors (GLP1Rs) in postmenopausal state. Furthermore, polymorphisms in GLP1R gene were suggested to affect the function of GLP1Rs and be associated with many diseases. However, the relationships between GLP1R polymorphisms and osteoporosis susceptibility and bone strength remain unexplored. To address this issue, a total of 458 Chinese Han postmenopausal women were included in this study. The bone mineral density (BMD) in the lumbar spine (L 2 -L 4 ) and femoral neck was measured by dual-energy X-ray absorptiometry (DEXA). A missense mutation (rs1042044) in GLP1R was genotyped using allele specific TaqMan probes. Our data showed that genetic variants of rs1042044 were significantly associated with osteoporosis (P = 0.003) and that the C allele of rs1042044 was a protective factor against osteoporosis compared to the A allele with gene dosage-dependent manner (OR, 0.579; 95% CI, 0.366 to 0.916 for AC genotype and OR, 0.404; 95% CI, 0.238 to 0.688 for CC genotype). These findings indicate that polymorphisms in GLP1R gene may affect BMD and development of osteoporosis in Chinese Han postmenopausal women, which provide novel insight into the mechanisms of osteoporosis development and target for personal prevention and treatment of osteoporosis.

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The relationship between osteoprotegerin gene polymorphisms and bone mineral density in Chinese postmenopausal women

Cited by 11 publications

References 40 publications

Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han

Polymorphism of glucagon-like peptide-1 receptor gene (rs1042044) is associated with bone mineral density in Chinese Han postmenopausal women

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