The Relationship Between Plasma Leptin Levels and Chronic Complication in Patients with Type 2 Diabetes Mellitus

Abstract

Our data suggest that obesity, hypertension, dyslipidemia, and metabolic syndrome in T2DM were associated with increased plasma leptin levels. We conclude that plasma leptin levels may not be strongly associated with microangiopathy and macroangiopathy in T2DM individuals.

Serum Leptin Levels in Type 2 Diabetes Mellitus with Chronic Complications

“…Accordind to kopeisy et al, leptin levels are significantly elevated in patients with microalbuminuria and macroalbuminuria compared to patients with normoalbuminuria 11,12 . Studies have also stated higher leptin levels in patients with diabetic neuropathy 13 . Microvascular complications of diabetes mellitus are principally due to vascular inflammation and leptin has deleterious effects on vasculature.…”

Immunological Risk Factors for the Development and Progression of Diabetic Retinopathy

“…(Gariano et al 2000. However, in other studies the authors reported no association between leptin and the development and progression of retinopathy (Sari et al, 2010).…”

Microinflammation as a Candidate for Diabetic Nephropathy

“…It also impairs endothelial cell functions, stimulates the proliferation of glomerular endothelial cells, increases TGF-β1 synthesis and collagen type IV production and upregulates surface TGF-β type II receptors through signal transduction pathways involving PI3K (phosphoinositide 3-kinase) [17]. In human settings, several reports demonstrated that serum leptin levels correlated with proteinuria in Type 2 DM [26]; however, others reported no association of serum leptin levels and the presence of DN [27]. Leptin also stimulates hypertrophy, but not proliferation of cultured rat mesangial cells, and infusion of leptin for 3 weeks into normal rats promotes the development of glomerulosclerosis and proteinuria [17].…”