The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood

Liu, Haixia; Pu, Yudong; Ai, Shiwei; Wang, Xiaoxue; He, Shuzhen; Wang, Ke; Dang, Yuhui

doi:10.1007/s12011-021-02988-5

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…The associations between individual metals and PE showed that elevated serum levels of Mn, Cu, Pb, and Hg were associated with the risk and severity of PE, while elevated serum levels of Zn and As were associated with the risk of mild and severe PE, respectively. Our results are in-line with a number of previous studies which have reported the relationship between individual metals including Cu (26,41), Pb (47), Hg (34), and As (33) and their association with PE. In contrary, there a study has reported an inverse dose-response relationship between Mn and PE (28), and a meta-analysis found significantly lower serum levels of Zn in PE patients (30).…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies have indicated significant relationships between the Cu (26) and Pb (27) levels in the maternal circulation and PE. Higher Mn (28,29) and Zn (30,31) levels were associated with lower risk of PE, whereas, elevated Cd (32), As (33) and Hg (34) levels, on the other hand, could potentially increase the risk of PE. Most of previous studies have focused to explore relationships between individual metal exposure and PE, however, the aforementioned toxic heavy metals concurrently present in environment and pregnant women are generally exposed to a variety of these metals simultaneously.…”

mentioning

confidence: 99%

“…Previous studies have predominantly investigated the correlation between individual metals and PE (32)(33)(34)(40)(41)(42). Furthermore, investigations exploring multiple metals have infrequently delved into their interactions (36,43), and the results have been inconsistent.…”

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confidence: 99%

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An exploratory study on the association of multiple metals in serum with preeclampsia

He,

Pu,

et al. 2024

Front. Public Health

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BackgroundIndividual metal levels are potential risk factors for the development of preeclampsia (PE). However, understanding of relationship between multiple metals and PE remains elusive.PurposeThe purpose of this study was to explore whether eight metals [zinc (Zn), manganese (Mn), copper (Cu), nickel (Ni), lead (Pb), arsenic (As), cadmium (Cd), and mercury (Hg)] in serum had a certain relationship with PE.MethodsA study was conducted in Dongguan, China. The concentrations of metals in maternal serum were assessed using inductively coupled plasma mass spectrometry (ICP-MS). Data on various factors were collected through a face-to-face interview and hospital electronic medical records. The unconditional logistic regression model, principal component analysis (PCA) and Bayesian Kernel Machine Regression (BKMR) were applied in our study.ResultsThe logistic regression model revealed that the elevated levels of Cu, Pb, and Hg were associated with an increased risk of PE. According to PCA, principal component 1 (PC1) was predominated by Hg, Pb, Mn, Ni, Cu, and As, and PC1 was associated with an increased risk of PE, while PC2 was predominated by Cd and Zn. The results of BKMR indicated a significant positive cumulative effect of serum metals on PE risk, with Ni and Cu exhibiting a significant positive effect. Moreover, BKMR results also revealed the nonlinear effects of Ni and Cd.ConclusionThe investigation suggests a potential positive cumulative impact of serum metals on the occurrence of PE, with a particular emphasis on Cu as a potential risk factor for the onset and exacerbation of PE. These findings offer valuable insights for guiding future studies on this concern.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

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An exploratory study on the association of multiple metals in serum with preeclampsia

He,

Pu,

et al. 2024

Front. Public Health

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“…These findings further suggest that iAs exposure could alter plasma volume expansion during pregnancy. In humans, exposure to iAs increased hemoglobin concentration and decreased blood protein concentration, indicating that iAs exposure may affect plasma volume regulation 64,65 . However, this has not been explored in the context of pregnancy.…”

Section: Akt and Anp Reduction In Maternal Hearts Exposed To Iasmentioning

confidence: 99%

Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

Taube,

Kabir,

Ebenebe

et al. 2023

Preprint

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Exposure to inorganic arsenic through drinking water is widespread and has been linked to many chronic diseases, including cardiovascular disease. Arsenic exposure has been shown to alter hypertrophic signaling in the adult heart, as well as in-utero offspring development. However, the effect of arsenic on maternal cardiac remodeling during pregnancy has not been studied. As such, there is a need to understand how environmental exposure contributes to adverse pregnancy-related cardiovascular events. This study seeks to understand the impact of trivalent inorganic arsenic exposure during gestation on maternal cardiac remodeling in late pregnancy, as well as offspring outcomes. C57BL/6J mice were exposed to 0 (control), 100 or 1000 µg/L sodium arsenite (NaAsO2) beginning at embryonic day (E) 2.5 and continuing through E17.5. Maternal heart function and size were assessed via transthoracic echocardiography, gravimetric measurement, and histology. Transcript levels of hypertrophic markers were probed via qRT-PCR and confirmed by western blot. Offspring outcomes were assessed through echocardiography and gravimetric measurement. We found that exposure to 1000 µg/L iAs abrogated normal physiologic growth of the maternal heart during late pregnancy and reduced transcript levels of estrogen receptor alpha (ERα), progesterone receptor membrane component 1 (Pgrmc1) and progesterone receptor membrane component 2 (Pgrmc2). Both 100 and 1000 µg/L iAs also reduced transcription of protein kinase B (Akt) and atrial natriuretic peptide (ANP). Akt protein expression was also significantly reduced after 1000 µg/L iAs exposure in the maternal heart with no change in activating phosphorylation. This significant abrogation of maternal cardiac hypertrophy suggests that arsenic exposure during pregnancy can potentially contribute to cardiovascular disease. Taken together, our findings further underscore the importance of reducing arsenic exposure during pregnancy and indicate that more research is needed to assess the impact of arsenic and other environmental exposures on the maternal heart and adverse pregnancy events.

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“…Among environmental pollutants, certain metals [e.g., arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg)] represent a serious concern to human health and, as being able to cross the placental barrier, they can act as developmental toxicants [14,15]. Indeed, they have been associated with increased risk for preterm birth, low birth weight, small-for-gestational age, preeclampsia, impaired neurodevelopment, and autonomic dysfunction [16][17][18][19][20][21]. However, the current evidence for a risk association between toxic metals exposure and CHD remains inconclusive due to the limited number of studies conducted, especially those using biological matrices [22].…”

Section: Introductionmentioning

confidence: 99%

Toxic metals in pregnancy and congenital heart defects. Insights and new perspectives for a technology-driven reduction in food sources

Gorini,

Tonacci

2023

Explor Cardiol

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Congenital heart defects (CHD) represent the most frequent congenital anomalies among newborns, as well as the leading cause of spontaneous abortion, stillbirth, neonatal and infant death. CHD have been recognized as multifactorial diseases, with environmental contaminants as potential contributors to the etiopathogenesis of CHD. Toxic elements, such as arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) are known to be associated with adverse reproductive outcomes and certain congenital anomalies, however their association with the risk for CHD remains inconsistent. This review summarizes the updated evidence on the CHD-associated risk related to exposure to As, Cd, Hg, Pb during pregnancy, reporting the main findings from epidemiological and experimental studies and the underlying molecular mechanisms. Additionally, being diet the major source of these elements in the general population, after having identified the main vectors of toxic metals in food, possible remediation strategies to reduce diet-related risks are also described. Among these, a novel, consumer-centered approach in developing new foods is discussed, considering not only the nutritional characteristics of edible compounds foods are made up of, but also their organoleptic features, making the food even more appealing to the consumer. Overall, current data support the association of maternal exposure to As and Pb with increased risk for CHD, although significant associations have only been observed for total and/or specific subgroups. On the other hand, the evidence of association for Cd and Hg exposure in pregnancy with CHD in the offspring remains, yet, quite speculative. Further large prospective cohort studies and insights into the molecular and biomolecular processes of these relationships are warranted to further explore and/or verify these findings.

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The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood

Cited by 9 publications

References 55 publications

An exploratory study on the association of multiple metals in serum with preeclampsia

An exploratory study on the association of multiple metals in serum with preeclampsia

Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

Toxic metals in pregnancy and congenital heart defects. Insights and new perspectives for a technology-driven reduction in food sources

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