The relationship between primary headache and constipation in children and adolescents

Park, Mina; Choi, Min-Gyu; You, Su Jeong

doi:10.3345/kjp.2015.58.2.60

Cited by 10 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, no such association was found among PWM. Another retrospective study of 96 patients with primary headache also found comorbid constipation in 25%, but this was mostly associated with tension-type headaches[ 56 ]. All studies reported a close correlation of constipation with headache severity, suggesting that it is this factor, together with the related affective and emotional distress, that more adequately explains the association.…”

Section: Other Functional Gi Disordersmentioning

confidence: 99%

Gastrointestinal disorders associated with migraine: A comprehensive review

Cámara-Lemarroy¹,

Rodríguez-Gutiérrez²,

Monreal-Robles³

et al. 2016

WJG

117

View full text Add to dashboard Cite

Migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. Migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. The physiopathology of migraine is complex and still not fully understood. Many different neuropeptides, neurotransmitters and brain pathways have been implicated. In connection with the myriad mechanisms and pathways implicated in migraine, a variety of multisystemic comorbidities (e.g., cardiovascular, psychiatric and other neurological conditions) have been found to be closely associated with migraine. Recent reports demonstrate an increased frequency of gastrointestinal (GI) disorders in patients with migraine compared with the general population. Helicobacter pylori infection, irritable bowel syndrome, gastroparesis, hepatobiliary disorders, celiac disease and alterations in the microbiota have been linked to the occurrence of migraine. Several mechanisms involving the gut-brain axis, such as a chronic inflammatory response with inflammatory and vasoactive mediators passing to the circulatory system, intestinal microbiota modulation of the enteric immunological milieu and dysfunction of the autonomic and enteric nervous system, have been postulated to explain these associations. However, the precise mechanisms and pathways related to the gut-brain axis in migraine need to be fully elucidated. In this review, we survey the available literature linking migraine with GI disorders. We discuss the possible physiopathological mechanisms, and clinical implications as well as several future areas of interest for research.

show abstract

Section: Other Functional Gi Disordersmentioning

confidence: 99%

Gastrointestinal disorders associated with migraine: A comprehensive review

Cámara-Lemarroy¹,

Rodríguez-Gutiérrez²,

Monreal-Robles³

et al. 2016

WJG

117

View full text Add to dashboard Cite

show abstract

“…[1] Patients with migraine who were also complaining of constipation were interviewed by a trained researcher (nursing student) based on the Rome III scale to examine their incidence of constipation. [8] The Rome III criteria classification system, also known as the only standardized symptom-based diagnostic criteria for functional gastrointestinal disorders (FGIDs), was used for recognizing the constipation. [1112] Patients with migraine who simultaneously suffered from constipation, those who signed the informed consent form, and those who were satisfied to participate in our study were divided into an experimental group and a control group.…”

Section: Methodsmentioning

confidence: 99%

“…It is likely that constipation plays a key role in starting a headache, or that headache and constipation have a common pathophysiology. [8] Constipation and migraines have common symptoms among which are pain and discomfort, which can lead to poor quality of life. Studies have shown that the prevalence of constipation in patients with primary headaches is higher than that of the normal population.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is a potential association between headache and constipation, which has been confirmed by some studies. [78] Yet, because of the very limited studies carried out in this area, it cannot unconditionally be stated that treatment of constipation can help improve migraine headaches. There are several drugs, such as magnesium, lactulose, polyethylene glycol, and sorbitol, to treat constipation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is the treatment of constipation can relieve the migraine symptoms? A randomized clinical trial study

Rezaeiashtiani

Jadidi

Khanmohammadi-Hezaveh

et al. 2019

J Pediatr Neurosci

View full text Add to dashboard Cite

Background:Many patients presenting with migraine also complain of constipation. The relationship between these two symptoms has not been explored yet in detail. This study, therefore, was carried out to investigate the effect of treatment of constipation with lactulose on the improvement of migraine headache in patients who referred to neurology clinics in Arak.Materials and Methods:A total of 50 patients with migraine were selected based on the Headache International Society (HIS) index and the Rome Foundation is an independent not for profit 501(c) 3 organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of functional gastrointestinal disorders (FGIDs) (ROME III) scale so as to diagnose their migraine and constipation. The patients were randomly divided into an experimental group and a control group. A 15 cc daily of lactulose syrup was prescribed to the experimental group with the antimigraine drugs (10-mg nortriptyline and 10-mg propranonol daily). In contrast, only the standard treatment for migraine was prescribed for the control group. The severity of disability was assessed based on the severity of migraine-induced disability (MIDAS) questionnaire. Having collected the data, the data analysis was carried out using Statistical Package for the Social Sciences (SPSS) (IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.) statistical t-tests, and repeated measures test.Results:The results of the independent sample t-test showed no significant difference between the control and intervention group’s main variables of the research before the intervention (P < 0.05). On the contrary, the results of the repeated measures test indicated that the mean scores ‑of the severity of disability and the severity of migraine pain between the measurement times were significantly different for the intervention and control groups, in a way that after one and/or two months of using lactulose syrup, the severity of disability and pain in the intervention group was lower than those of the control group (P < 0.001).Conclusion:Short-term follow-up of this study showed that lactulose syrup could remove the constipation with no significant side effects––can be used as an adjunct for the treatment of patients with migraine. However, future studies suggested for long-term consequences of constipation control.

show abstract

“…After every reflux, there is a peristaltic wave in oesophagus which clears the gastric contents (16,33) . Almost 20% of adults complain of atleast 1 episode of heartburn/week and about 10% of them complain of daily episode of heartburn due to various trigerring factors mainly stress and sedentary lifestyle (8,14,45) .…”

Section: Discussion and Conclusion:-mentioning

confidence: 99%

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

MS¹

2017

IJAR

View full text Add to dashboard Cite

Introduction: Over the years, there has been a dilemma regarding arriving at a diagnosis for headache pertaining to its variety of causes. One of the most common overlooked cause in the present day scenario for headache is GERD and Migraine. On day to day basis, we come across varied patient symptomatology which has indeed made us give a second thought to prescribe on management. Aim and Objective: To study if GERD and Migraine actually co-exist or they have a separate root cause for headache and also how change in lifestyle has an impact on health. Methodology: A study of random sample of 450 patients was conducted based on clinical evaluation for diagnosis and conservative management for the same was advised emphasising particularly on lifestyle modification. Results:The results drawn were compared by tabulating them into 3 groups with the two conditions taken as a separate entity and third when the two being mingled to conclude if interlink exists between the two conditions or purely is it a myth. Conclusion: Intermingling of GERD and Migraine was noted predominantly in our study rather than their separate existence.

show abstract

The relationship between primary headache and constipation in children and adolescents

Cited by 10 publications

References 24 publications

Gastrointestinal disorders associated with migraine: A comprehensive review

Gastrointestinal disorders associated with migraine: A comprehensive review

Is the treatment of constipation can relieve the migraine symptoms? A randomized clinical trial study

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

Contact Info

Product

Resources

About