The relationship between psychosocial factors and biomarkers in cancer patients: A systematic review of the literature

Cheng, Lin; Meiser, Bettina

doi:10.1016/j.ejon.2019.06.002

Cited by 7 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the possible mechanism involved, failing to adapt to altered body image may have resulted in psychological distress and chronic stress, which were shown in research to cause cancer patients’ fatigue, impaired sleep, and cognitive dysfunction by affecting the neuroendocrine system and inducing inflammation [ 32 ]. This mind–body interaction has received much research attention in cancer survivors; lower positive psychosocial factors (e.g., less social support) and higher negative psychosocial factors (e.g., higher anxiety and perceived stress) were associated with biomarkers indicating worse clinical outcomes (e.g., chronic elevations of cortisol) [ 33 , 34 ]. Our findings align with our conceptual framework in that they affirm the correlations between multiple body image and QoL domains.…”

Section: Discussionmentioning

confidence: 99%

Assessing the relationship between body image and quality of life among rural and urban breast cancer survivors in China

Zhou

2022

BMC Women's Health

View full text Add to dashboard Cite

Background Breast cancer survivors experience altered body image and quality of life (QoL) due to the disease and its treatment. The multidimensional nature of body image and QoL makes their relationships complex. This study aimed to examine the associations between the two concepts in Chinese breast cancer survivors and test whether these associations are moderated by rural–urban residence. Methods A cross-sectional design was adopted. Breast cancer survivors were recruited via a convenience sampling method. Two validated questionnaires (the Body Image Self-Rating Questionnaire for Breast Cancer and 36-item Short-Form Health Survey) and questions assessing demographic and clinical covariates were administered. Multiple linear regressions were used to assess the relationship between body image and QoL domains and to examine the moderating effect of rural–urban residence. Results In our sample of 354 breast cancer survivors, half (50.28%) lived in rural areas. After adjusting for demographic and clinical variables, better perception of body image-related sexual activity change, role change, and psychological change was significantly associated with better physical (β ranged from − 0.15 to − 0.11, p < 0.05) and mental (β ranged from − 0.46 to − 0.34, p < 0.001) well-being. Better perception of body image-related social and behavior change was significantly associated only with better mental well-being (β ranged from − 0.40 to − 0.33, p < 0.001). The association between body image and mental well-being was much stronger in urban subjects (b = − 0.38, p < 0.001) than in rural subjects (b = − 0.20, p < 0.001). Conclusions Our findings suggest that multidimensional body image is associated with physical and mental well-being in Chinese breast cancer survivors. Body image appears to play a larger role in urban breast cancer survivors’ mental well-being. Our results indicate that incorporating interventions that address body image issues would be advantageous for survivorship care to enhance QoL in breast cancer survivors. Furthermore, rural–urban differences should be considered in the strategic design of survivorship care programs in rural and urban settings.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessing the relationship between body image and quality of life among rural and urban breast cancer survivors in China

Zhou

2022

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…A huge motivation in designing magnetic nanoparticles (MNPs) and their subsequent applications in biomedical and pharmaceutical fields such as bio-imaging, diagnosis and treatment of cancer, tissue engineering, etc. has been noticed. , Although numerous drugs such as doxorubicin, cytarabine, cisplatin, etc. have been employed in the treatment of various types of cancers, the drug 5-fluorouracil has emerged as a promising chemotherapeutic agent in cancer therapy, which prevents cell division by cross-linking the DNA.…”

Section: Introductionmentioning

confidence: 99%

“…has been noticed. 1,2 Although numerous drugs such as doxorubicin, cytarabine, cisplatin, etc. have been employed in the treatment of various types of cancers, the drug 5-fluorouracil has emerged as a promising chemotherapeutic agent in cancer therapy, which prevents cell division by crosslinking the DNA.…”

Section: Introductionmentioning

confidence: 99%

Predictions of Drug–Protein Interactions and Study of Magnetically Assisted Release Dynamics of 5-Fluorouracil from Soya Protein-Coated Iron Oxide Core–Shell Nanoparticles

Jain¹,

Sonker²,

Bajpai³

et al. 2020

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In silico studies were performed using 5-fluorouracil (5-FU) to explore the efficacy of template docking and facilitate designing of drug nanocarrier systems. The binding of human uridine phosphorylase (huPP1) with 5-FU was found to show the following interactions: (1) hydrogen bonds were alleviated by a network of GLN217 and ARG219, (2) hydrophobic interactions were shown by PHE213, THR141, LEU272, and ILE281 (3) positive electrostatic interactions were shown by PHE213, THR141, LEU272, SER142, GLU248, and GLY143. As an experimental supplementation and validation to the adopted computational approach, 5- FU-loaded soya protein-coated iron oxide (SPCIO) core–shell nanoparticles were prepared following microemulsion and co-precipitation techniques and subsequently characterized by FTIR, particle size and zeta potential studies, TEM, XRD, and DSC techniques. Whereas the FTIR spectra confirm the presence of the soya protein and drug 5-FU in the nanoparticles, the zeta potential was found to be suppressed due to the loading of 5-FU. The XRD study confirmed the crystalline nature of the drug-loaded nanoparticles. TEM analysis suggested that the nanoparticles have sizes up to 200 nm and the morphology and size remain almost the same even after loading of the drug 5-FU onto nanoparticles. The soya protein-coated iron oxide nanoparticles demonstrated zero cytotoxicity against fibroblast cells. The controlled release of 5-FU was studied in vitro, and the effects of pH, chemical composition of nanoparticles, extent of drug loading, and simulated biofluids on the controlled release of 5-FU were studied. The swelling of nanoparticles and release of 5-FU were found to increase with increasing strength of the externally applied magnetic field.

show abstract

“…Failing to adapt to altered body image resulted in psychological distress and chronic stress, which were shown in research to cause cancer patients' fatigue, impaired sleep, and cognitive dysfunction by affecting the neuroendocrine system and inducing in ammation [30]. This mind-body interaction has received much research attention in cancer survivors; lower positive psychosocial factors (e.g., less social support) and higher negative psychosocial factors (e.g., higher anxiety and perceived stress) were associated with biomarkers (e.g., chronic elevations of cortisol) indicating worse clinical outcomes [31,32].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Relationship between Body Image and Quality of Life Among Rural and Urban Breast Cancer Survivors in China

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose This study aimed to examine the associations between multidimensional body image and quality of life (QoL) and test whether the associations between body image and QoL are moderated by rural-urban residence in Chinese breast cancer survivors. Methods A cross-sectional design was adopted. Breast cancer survivors were recruited via a convenience sampling method. Two validated questionnaires (Body Image Self-Rating Questionnaire for Breast Cancer and SF-36) and questions assessing demographic and clinical covariates were administered. Results In our sample of 354 breast cancer survivors, half (50.28%) lived in rural areas. After adjusting for demographic and clinical variables, better perception of body image-related sexual activity change, role change, and psychological change was significantly associated with better physical and mental well-being. Better perception of body image-related social and behavior change domains was only significantly associated with better mental well-being. The association between body image and mental well-being was much stronger in urban subjects (b = -0.38, p < 0.001) than in rural subjects (b = -0.20, p < 0.001). Conclusions Our findings suggest that multidimensional body image is associated with physical and mental well-being in Chinese breast cancer survivors. Body image appears to play a larger role in urban breast cancer survivors’ mental well-being. Our findings indicate that incorporating interventions that address body image issues would be advantageous for survivorship care programs focused on enhancing QoL in breast cancer survivors. Considering the rural-urban differences supports strategic design of the care programs in rural and urban settings.

show abstract

The relationship between psychosocial factors and biomarkers in cancer patients: A systematic review of the literature

Cited by 7 publications

References 50 publications

Assessing the relationship between body image and quality of life among rural and urban breast cancer survivors in China

Assessing the relationship between body image and quality of life among rural and urban breast cancer survivors in China

Predictions of Drug–Protein Interactions and Study of Magnetically Assisted Release Dynamics of 5-Fluorouracil from Soya Protein-Coated Iron Oxide Core–Shell Nanoparticles

Assessing the Relationship between Body Image and Quality of Life Among Rural and Urban Breast Cancer Survivors in China

Contact Info

Product

Resources

About