The Relationship between Saccades and Locomotion

Srivastava, Anshul; Ahmad, Omar F.; Pacia, Christopher Pham; Hallett, Mark; Lungu, Codrin

doi:10.14802/jmd.18018

Cited by 27 publications

(21 citation statements)

References 197 publications

(135 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than that, there is evidence that the disorder of body movement system leads to the constraining eye movement in patients with Parkinson's disease (Ambati et al, 2016), which implies a common or interactive system to control eye and body movement simultaneously (Srivastava et al, 2018). The current study may also shed lights on the potential clinical anchor points of the disorders in locomotion-eye coordination with zebrafish model (Huang and Neuhauss, 2008).…”

Section: Zebrafish As a Good Candidate For Internal Model Researchmentioning

confidence: 73%

Neural circuits mediating visual stabilization during active motion in zebrafish

Sun

Zuo

et al. 2019

Preprint

View full text Add to dashboard Cite

Visual stabilization is an inevitable requirement for animals during active motion interaction with the environment. Visual motion cues of the surroundings or induced by self-generated behaviors are perceived then trigger proper motor responses mediated by neural representations conceptualized as the internal model: one part of it predicts the consequences of sensory dynamics as a forward model, another part generates proper motor control as a reverse model. However, the neural circuits between the two models remain mostly unknown. Here, we demonstrate that an internal component, the efference copy, coordinated the two models in a push-pull manner by generating extra reset saccades during active motion processing in larval zebrafish. Calcium imaging indicated that the saccade preparation circuit is enhanced while the velocity integration circuit is inhibited during the interaction, balancing the internal representations from both directions. This is the first model of efference copy on visual stabilization beyond the sensorimotor stage.

show abstract

Section: Zebrafish As a Good Candidate For Internal Model Researchmentioning

confidence: 73%

Neural circuits mediating visual stabilization during active motion in zebrafish

Sun

Zuo

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, patients with PD with postural instability have slower anti-saccade latencies compared to those without postural instability; further, the latency correlated with some indices of postural instability 13 . Furthermore, there is significant overlap in the neural circuit controlling locomotion and saccade 40 . These results suggest that there are shared brain mechanisms involved in both difficulties in anti-saccade and PIGD.…”

Section: Discussionmentioning

confidence: 99%

Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease

Okada

Takahira

Mano

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a progressive neurological disorder characterised by motor and non-motor deficits. Repetitive transcranial magnetic stimulation (rTMS) over the bilateral primary motor cortex at a high frequency (5 Hz or higher) is reported to be a potential treatment of PD. We aimed to assess the effect of rTMS on eye movement control in patients with PD in their ‘on’ state. We enrolled 14 patients with PD and assessed motor symptoms (Movement Disorder Society-Sponsored Unified Parkinson’s Disease Rating Scale; MDS-UPDRS) and eye movement performances (visually guided saccades, volitional anti-saccades, and small involuntary saccades during fixation) at baseline and after administering bilateral 10 Hz rTMS on leg region of the motor cortex. We confirmed that rTMS improved the MDS-UPDRS motor scores and found that rTMS improved the anti-saccade success rate, which requires adequate inhibition of the reflexive response. The improvement in anti-saccade success rate was correlated with that of the postural instability gait difficulty (PIGD) sub-scores of MDS-UPDRS and lower baseline Japanese version of the Montreal Cognitive Assessment scores. This result is consistent with previous findings that PIGD and inhibitory control deficits share common brain dysfunctions in PD. rTMS may alleviate dysfunctions of that circuit and have a clinical effect.

show abstract

“…Considering the neural or Hebbian learning, stimulating brain on a regular basis adjusts brain functions at the molecular level (e.g., signaling mechanisms and memory formation) (89). Eye movement exercises are identi ed to activate widespread, interconnected cortical and subcortical networks such as superior colliculus, oculomotor network (ON) in the brain stem, dorsolateral prefrontal brain cortex, basal ganglia, subthalamic structures, substantia nigra pars reticulata, visuo-motor, parietal, and posterior cingulate cortices (90)(91)(92)(93)(94). Each of these networks plays an excitatory or inhibitory role in pain processing (95,96).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Jogging, Eye Movement Exercises, and Diaphragmatic Breathing in Reducing Migraine Symptoms: A Randomized Controlled Trial

Rahimi

Alidoosti

Hassani

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: electrophysiological dysresponsiveness (ED) is apparent in a migraine brain. Various methods have been suggested to regulate ED, including electrochemical transduction or regulation of Nitric Oxide (NO) and Brain-Derived Neurotrophic Factor (BDNF), jogging, eye movement exercises, and diaphragmatic breathing.Objectives and methods: A three-group, double-blind, and randomized design with pre-test, post-test, and follow-up assessment was used to test the effectiveness of jogging, eye movement exercises, and diaphragmatic breathing in the treatment of patients with episodic migraine. International Classification of Headache Disorders 3rd edition (ICHD-3) was used to diagnose the migraine patients, who were randomly assigned to one of the three study groups to perform either 12 consecutive weeks of (a) jogging and eye movement exercises (n = 22) ;(b) jogging and diaphragmatic breathing (n = 19); or (c) treatment as usual (TAU), receiving prescribed medication (n = 22) group.Results: The results of a series of MANCOVA showed that, compared to the TAU group, patients in the two experimental groups showed significant reductions in the frequency, duration, and intensity of their episodic migraine attacks. Moreover, the frequency of menstrual cycle-dependent headache attacks and over the counter drugs use were reduced, and the quality of sleep and drinking water were improved at post-test and a 12-month follow-up.Conclusion: The results suggest that jogging and eye movement exercises or jogging and diaphragmatic breathing can be used as effective alternative interventions in the treatment of episodic migraine.Trial registration retrospectively: Ir.mums.fm.rec.1396.362

show abstract

The Relationship between Saccades and Locomotion

Cited by 27 publications

References 197 publications

Neural circuits mediating visual stabilization during active motion in zebrafish

Neural circuits mediating visual stabilization during active motion in zebrafish

Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease

Effectiveness of Jogging, Eye Movement Exercises, and Diaphragmatic Breathing in Reducing Migraine Symptoms: A Randomized Controlled Trial

Contact Info

Product

Resources

About