The relationship between salivary insulin-like growth factor I and quantitative cervical maturational stages of skeletal maturity

Nayak, Subash Chandra; Bhad, Wasundhara A.; Doshi, Umal H.

doi:10.1179/1465313313y.0000000091

Cited by 15 publications

(27 citation statements)

References 21 publications

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“…It has been suggested that salivary cortisol can be used as a surrogate of free serum cortisol thus offering some advantages over measurements of serum cortisol (Estrada & Orlander, ). However, age, gender, developmental stage, body mass index, sampling and assay conditions are all variables which should be taken into account in studies that use salivary cortisol as a marker (Jessop & Turner‐Cobb, ; Nayak, Bhad Patil, & Doshi, ).…”

Section: Saliva Diagnostics In Conditions Related To Hypothalamic‐pitmentioning

confidence: 99%

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Saliva in the “Omics” era: A promising tool in paediatrics

2018

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In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its noninvasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination. In this review, we provide an overview of current and future applications of saliva diagnostics to various diseases and conditions and highlight studies in paediatrics across the "omic" spectrum. Emerging frontiers in salivary diagnostics research that may significantly advance the field are also highlighted.

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Section: Saliva Diagnostics In Conditions Related To Hypothalamic‐pitmentioning

confidence: 99%

“…Salivary proteomics are also utilized to identify skeletal growth markers during childhood. Salivary insulin growth factor (IGF‐1) was found to be a promising indicator of skeletal maturity (Nayak et al., ). In a pilot study by Wetie et al.…”

Section: Salivary Proteomicsmentioning

confidence: 99%

Saliva in the “Omics” era: A promising tool in paediatrics

2018

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“…The age group in the studies ranged from 6 to 24 years. The noninvasive methods used were saliva [23][24][25][26][27][28][29][30], GCF [31][32][33], and urine [34].…”

Section: Resultsmentioning

confidence: 99%

“…Out of the 12 articles, 8 studies [23][24][25][26][27][28][29] employed saliva as their sample. The biomarkers assessed in the eight studies were insulin-like growth factor 1 (IGF1) [23,29], alkaline phosphatase (ALP) [26,27,34], bone-specific alkaline phosphatase (B-ALP) [24,25], vascular endothelial growth factor (VEGF) [29], and dehydroepiandrosterone (DHEA) [30].…”

Section: Salivamentioning

confidence: 99%

Non-invasive methods for the assessment of biomarkers and their correlation with radiographic maturity indicators — a scoping review

Tripathi

2021

Prog Orthod.

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Background Detection of skeletal maturity is vital in orthodontic treatment timing and planning. Traditional methods include hand-wrist radiography and cervical vertebral maturation index (CVMI). Though the radiographic methods are well established and routinely used to assess skeletal maturation, they carry the drawback of subjective perception and low reproducibility. With evolving concepts, skeletal maturation has been assessed quantitatively through biomarkers obtained from saliva, gingival crevicular fluid (GCF), and urine. The scoping review aims to explore the various biomarkers assessed through non-invasive methods and their correlation with radiographic skeletal maturity. Methodology The literature search was carried out on MEDLINE via Pubmed, Cochrane Library (Cochrane database of systematic reviews), Cochrane central register of controlled trials (CENTRAL), Google Scholar, Semantic Scholar, ScienceDirect, and Opengrey.eu for articles up to and including November 2020. Pertinent articles were selected based on inclusion and exclusion criteria. The results were tabulated based on the type of sample collected, the biomarker assessed, method of sample collection, and the radiographic method used. Results The literature search resulted in 12 relevant articles. Among all the studies, 10 studies showed that the concentration of biomarkers increases during the pubertal growth peak. On the contrary, 2 articles showed no significant difference between the levels of biomarkers and pubertal growth peak. Conclusion It can be concluded that the level of biomarkers increases during the pubertal growth spurt and can provide a quantitative way of assessing skeletal maturity.

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“…For example, concentrations of salivary insulin growth factor ( IGF-I ) may vary and serve as an indicator of skeletal growth throughout childhood (71). Nutritional status of the child also affects salivary biomarkers.…”

Section: Salivary “Omics”mentioning

confidence: 99%

Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations

Hassaneen

Maron

2017

Front. Public Health

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In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive “omic” analyses of saliva could significantly improve care and enhance health access. In this review, we will highlight novel applications of salivary diagnostics in pediatrics across the “omic” spectrum, including at the genomic, transcriptomic, proteomic, microbiomic, and metabolomic level. The challenges to implementing salivary platforms into care, including the effects of age, diet, and developmental stage on salivary components, will be reviewed. Ultimately, large-scale, multicenter trials must be performed to establish normative biomarker values across the age spectrum to accurately discriminate between health and disease. Only then can salivary diagnostics truly translate into pediatric care.

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The relationship between salivary insulin-like growth factor I and quantitative cervical maturational stages of skeletal maturity

Abstract: Salivary IGF-I levels or its secretion rate can be used as an indicator of skeletal growth but longitudinal data are necessary to confirm salivary IGF-I as a marker for skeletal growth prediction and residual mandibular growth.

Cited by 15 publications

References 21 publications

Saliva in the “Omics” era: A promising tool in paediatrics

Saliva in the “Omics” era: A promising tool in paediatrics

Non-invasive methods for the assessment of biomarkers and their correlation with radiographic maturity indicators — a scoping review

Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations

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