The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury

Chen, Tiejiang; Ji, Mingxia; Tao, Zhiqiang; Fu, Qing-Yang; Xiong, Kai; Bin, Cheng

doi:10.1016/j.cca.2018.11.033

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Intriguingly, FGL2 can be produced from animal brain tissues after ischemic or hemorrhagic injury (Yuan et al, ; Zhang et al, ). Of note, in a recent study, serum FGL2 levels tended to strongly correlate with cerebral infarct size in rats with acute cerebral ischemic‐reperfusion injury (Zhang et al, ); more recently, serum FGL2 levels were prone to increase in severe traumatic brain injury and its elevation was highly relevant to clinical severity and mortality (Chen et al, ), indicating that FGL2 should be a promising biomarker for brain injury. To the best of my knowledge, it is unclear whether circulating sFGL2 is related to delirium after AP.…”

Section: Introductionmentioning

confidence: 98%

Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis

et al. 2019

Brain and Behavior

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Objective Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). Materials and Methods In this prospective, observational study, serum sFGL2 concentrations were quantified in 184 healthy controls and in 184 AP patients. Disease severity was assessed by Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, and sequential organ failure assessment score. Delirium was recorded during hospital stay. Predictors of delirium were identified using multivariate analysis. Results Serum sFGL2 concentrations were substantially higher in AP patients than in controls. Serum sFGL2 concentrations were intimately correlated with the preceding severity parameters. Serum sFGL2 and the aforementioned severity parameters were independent predictors for delirium. Under receiver operating characteristic curve, the discriminatory ability of serum sFGL2 was equivalent to those of the above‐mentioned severity parameters. Moreover, serum sFGL2 dramatically improved the predictive value of the aforementioned severity parameters. Conclusions Elevation of serum sFGL2 concentrations is strongly associated with the AP severity and has the potential to distinguish delirium after AP.

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Section: Introductionmentioning

confidence: 98%