The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea

Jung, Young Saeng; Chae, Chang Ho; Kim, Young Ouk; Son, Jun Seok; Kim, Chan Woo; Park, Hyoung Ouk; Lee, Jun Ho; Shin, Young Hoo; Kwak, Ho Sung

doi:10.1186/s40557-017-0187-7

Cited by 33 publications

(26 citation statements)

References 46 publications

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“…Kim et al [22] reported a positive relationship between serum 25(OH)D concentrations and sleep duration, whereas Shiu [23] found no significant association. In contrast to our results, Jung et al demonstrated a correlation between 25(OH)D levels and sleep quality using PSQI [26]. While Beydoun et al [25] reported an inverse relationship between serum 25(OH)D concentration and sleepiness (i.e.…”

Section: Discussioncontrasting

confidence: 99%

“…However, only a marginal negative association was reported between serum 25(OH)D concentrations and very short sleep, when a sub-group with very short sleep duration (<5 hours per night) was compared to a sub-group with normal sleep duration (7–8 hours per night). Among Korean workers an odds ratio of 1.43 for having poor sleep quality (PSQI (Pittsburgh Sleep Quality Index) score<5) was found in case of vitamin D deficiency (<10 ng/mL) [26].…”

Section: Introductionmentioning

confidence: 99%

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Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample

et al. 2019

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Background Sleep disorders and vitamin D deficiency are among the most common health problems. Few studies investigated the effect of vitamin D on objectively recorded sleep with sound methodological quality and reasonable temporal proximity. Objective To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and objective sleep parameters assessed within close temporal proximity in a population-based sample. It is expected that higher serum 25(OH)D concentrations are associated with 1) better objective sleep outcomes (longer sleep duration, higher sleep efficiency, earlier mid-sleep time) and 2) more positive subjective sleep evaluations. Methods A subset of participants (n = 1045) from the LIFE-Adult-Study was analysed. Measurement of serum 25(OH)D vitamin was performed using an electrochemiluminescence immunoassay. Actigraphic assessments were performed using SenseWear Pro 3 devices. The following objective sleep parameters were calculated: total sleep duration, night sleep duration, night sleep efficiency, midsleep time and wake after sleep onset (WASO). Subjective sleep evaluations were assessed via questionnaire (sleep quality (PSQI), daytime sleepiness (ESS)). Data were analysed applying a multiple linear regression model with a stepwise approach. Results The regression models revealed significant associations of serum 25(OH)D concentration with night sleep duration and midsleep time. No association was found for total sleep duration and night sleep efficiency. Higher serum 25(OH)D concentration was further associated with shorter WASO in males but longer WASO in females. Moreover, serum 25(OH)D concentration did not show any significant association with subjective sleep quality and daytime sleepiness. Conclusion The results indicate that a higher concentration of serum 25(OH)D is associated with longer and earlier night sleep. Although the present study was able to demonstrate an association between serum 25(OH)D concentration and objective sleep parameters, no conclusion about underlying mechanisms or causal inferences can be drawn.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample

et al. 2019

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“…As a result, 9 studies were included in our meta-analysis. The detailed study selection is described in Figure 1 [ 20 , 26 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most studies were mixed gender, two included only women [ 26 , 33 ], and one was only male [ 20 ]. For vitamin D deficiency cut-off value, the included studies mainly used 20 ng/mL [ 20 , 26 , 31 , 33 , 35 ] in accordance with the criteria suggested by Institute of Medicine (IOM) [ 38 ]; three studies used 30 ng/mL [ 32 , 34 , 37 ], and only one study used 10 ng/mL [ 36 ] as the cut-off value. Seven of the nine studies adjusted for potential confounding factors, whereas other studies provided only crude-effect estimates.…”

Section: Resultsmentioning

confidence: 99%

The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

et al. 2018

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Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

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“…Patients with sleep disturbance showed lower levels of 25(OH)D as compared to those without sleep disturbance. Jung et al (23) investigated serum vitamin D levels in fixed day indoor workers in the manufacturing industry and analyzed the relationship of vitamin D deficiency with sleep quality. A significant correlation was observed between serum vitamin D deficiency and poor sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Blood melatonin level can serve as a potential biomarker for prostate and hepatocellular carcinomas

et al. 2021

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Many systemic functions display circadian rhythms driven by an endogenous mechanism that is regulated by circadian-related genes and these gene expressions control a central clock in the brain and subordinate clocks in peripheral tissues. However, modern life has introduced environmental factors that often interfere with natural circadian rhythms. Importantly, circadian disruption has been identified as an independent risk factor of cancers. Melatonin is a major circadian rhythm regulator. In cancer patients, the rhythm of melatonin is often disrupted and its level is also reduced. These changes of melatonin impair its antioxidant and circadian regulatory functions on cells and tissues making them more susceptible to mutations and cancer initiation. In this context, the objectives of this study are to evaluate the sleep quality and blood levels of melatonin in patients with either prostate cancer (PC) or hepatocarcinoma (HCC) with the intent of using its levels as a potential biomarker of the cancers. The study involved 20 PC and 18 HCC patients, and 26 healthy volunteers. All blood samples were collected in the early morning, at 07:00 hours. Comparative sleep quality between PC, HCC patients and control subjects was acessed with a questionnaire, and melatonin and vitamin D were measured using conventional assays. The results revealed that patients with the worse sleep quality also had lower values of melatonin and vitamin D compared to control subjects. Notably, expression of melatonin-synthesizing enzymes and specific clock genes (PER, CRY and BMAL1) were significantly reduced and associated with worse prognosis in PC and HCC patients. These findings are consistent with the results of previous studies and suggest that disruption of the circadian rhythms, associated with changes in the light:dark cycle, has consequences for the maintenance of systemic health. We suggest that supplementation of melatonin and vitamin D may represent the important therapeutic strategies for patients with solid tumors for the purpose of improving their sleep quality and recuperative capacity.

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The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea

Cited by 33 publications

References 46 publications

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample

Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample

The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

Blood melatonin level can serve as a potential biomarker for prostate and hepatocellular carcinomas

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