The relationship between some biochemical and hematological changes in type 2 diabetes mellitus

Shehri, Zafer Saad Al

doi:10.15419/bmrat.v4i11.382

Cited by 16 publications

(9 citation statements)

References 12 publications

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“…Results of previous studies conducted by Wu et al. [14] and Al Shehri [1] align with those of our study that have revealed that Type 2 diabetes is associated with elevated HbA1c, cholesterol, triglyceride, LDL with lower HDL and shortened telomere length, compared to the control group. Hyperglycaemia and dyslipidaemia increase reactive oxygen species (ROS) from the mitochondrial electron transport chain in Type 2 diabetes and diabetes-associated complications.…”

Section: Discussionsupporting

confidence: 92%

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Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients

Al‐Shuhaib

2021

J Diabetes Metab Disord

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Introduction A wide range of antidiabetic therapies have been developed to manage diabetes and limit its lifespan but each of them have adverse long-term drug reactions. This study was performed for the investigation of the possible association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients. Materials and methodsThe subjects in this case-control study included 100 non-diabetic patients and 300 patients with Type 2 diabetes with ages in the range of 30-50 years. The treated patients were further subdivided into diabetic patients using Doanil, those using insulin and those using both the therapies. The mean telomere length was determined using the southern-blotting technique. A logistic regression analysis was performed to predict the relationship between antidiabetic therapy and shortened telomere length. ResultsThe results revealed a significant increase (P < 0.01) in the fasting blood glucose and lipid profile in non-treatment diabetic patients compared to diabetic patients with treatment, and also in diabetic patients with insulin therapy, compared to diabetic patients with Doanil or both therapies. The results showed that non-treatment diabetic patients had shorter telomere length, compared to the diabetic patients with treatment, and patients treated with insulin therapy had shorter telomere length, compared to the diabetic patients with Doanil or both therapies. The logistic regression analysis confirmed that insulin therapy was closely related to diabetic risk factors and shortened telomere length. Conclusions The results revealed that Doanil therapy was more effective in managing diabetic risk and limiting the shortening telomere length than insulin therapy.

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Section: Discussionsupporting

confidence: 92%

“…Many diseases have reached epidemic proportions worldwide, but among the most important is Type 2 diabetes mellitus [1]. A primary cause of diabetes is the lack of insulin secretion or its action, which leads to dyslipidaemia and other complications [2].…”

Section: Introductionmentioning

confidence: 99%

Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients

Al‐Shuhaib

2021

J Diabetes Metab Disord

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“…Biochemical and haematological factors in type 2 diabetes mellitus patients and the controlled group was studied by Shehri in 2017 and found that type 2 diabetes mellitus patientsʼ biochemical and haematological characters are distinct from control subjects 17 .…”

Section: Resultsmentioning

confidence: 99%

Survey on Biochemical Parameters of Type 2 Diabetic Patients in Faizabad, India

Ahmed¹,

Jayalakshm²,

Sundar³

2022

Asian J. of Biochemistry

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Background and Objective: Type 2 Diabetes Mellitus (DM) is a chronic metabolic illness that is becoming more common across the world.As a result of this trend, it is rapidly becoming an epidemic in some countries around the world, with the number of people affected expected to double in the next decade due to an increase in the elderly population, adding to the already existing burden on healthcare providers, particularly in less developed countries. Type 2 Diabetes Mellitus (T2DM) accounts for around 90% of all diabetes cases. The present study aimed to investigate the biochemical profile of type 2 diabetes patients. Materials and Methods: Survey on diabetes prevalence and biochemical profiles like Blood Glucose, Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic-Oxaloacetic Transaminase (SGOT), serum bilirubin (total), serum bilirubin (direct), alkaline phosphatase, total serum cholesterol, High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) of selected people was done. Results: From the survey, it was found that type 2 diabetes is more prevalent among the rural population. Male with age group 50-80 is more prone to diabetes. Conclusion: Diabetes patients had higher total cholesterol, triglycerides, low-density lipoprotein levels and lower levels of high-density lipoprotein than normal healthy controls.

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“…Daily swimming training can be beneficial effects on blood parameters in diabetics (12,21). Some studies showed that exercise activities have significantly improved hematocrit, hemoglobin levels and RBC count in pregnant women, athletes, patients with T2DM, and STZ induced diabetic (36,38). In diabetic animals and humans, a relative decrease in lymphocyte ratios in leukocyte types and an increase in neutrophil count were observed (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Diyabetik Sıçanlarda Yüzmenin Bazı Kan Parametreleri Üzerine Olumlu Etkisi

Dönmez¹,

Keskin²,

ÖZSAN³

et al. 2020

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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To investigate the effect of swimming on some hematological parameters in diabetic rats is the main goal of this study. 32 adult healthy rats were divided into Control (C), Diabetic (D), Exercise Control (E) and Diabetic+Exercise (DE) groups respectively. The rats in the control group were not soever treated, while the D and DE groups were injected 60 mg / kg streptozotocin (STZ) intraperitoneal (i.p). The trial continued for four weeks after the onset of diabetes. After the diabetes was formed, 1-hour swimming exercise for 4 weeks, 5 days a week was applied to groups E and DE during the trial period. At the end of the experiment (after 4 week) some hematological parameters (such as RBCs, Hb, Htc, platelet, WBC, differential leucocyte count) were determined in blood samples. RBCs, Hb and Htc values were reduced in D group. On the other hand, WBC and platelet count were increased in the same group. We observed RBC count, Hb and Htc levels were higher and WBC count was lower in DE group according to D group. As a result; current study was observed that regular aerobic exercise improves investigated parameters and demonstrates positive effects.

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The relationship between some biochemical and hematological changes in type 2 diabetes mellitus

Cited by 16 publications

References 12 publications

Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients

Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients

Survey on Biochemical Parameters of Type 2 Diabetic Patients in Faizabad, India

Diyabetik Sıçanlarda Yüzmenin Bazı Kan Parametreleri Üzerine Olumlu Etkisi

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