The Relationship between Some Inflammatory Proteins and Autoantibodies in Diabetic Type II Patients

Abstract

Diabetes mellitus type II considers as inflammatory disease, which it associated with increasing level of sensitive inflammatory proteins, Adult patients with DM type II may progress a slowly failure of Beta-cells. Some patients show an autoimmune nature of the disease, our Present study aimed toevaluatethe relationship between autoantibodies which includes islet cell antibodies and insulin autoantibodies along with some inflammatory sensitive proteins like Ceruleplasminand Transferrinin type II diabetes mellitus of recent onset disease in an Iraqi population. A total of 50 patients with type II diabetes mellitus were studied as well as 31 control healthy individuals,the individuals in each group were divided into sub groups according to the presence of autoantibodies. The present study tested the presence of both autoantibodies against islet cells in both patients and control groups, the results show the presence of at least one type of autoantibodies and the coexistence of two types of autoantibodies where observed in three patients, therefore, the individuals in each group were divided into sub groups according to the presence of autoantibodies. Serum Ceruloplasmin level showed significant increasing between negative patients group and negative control group, but this increasing is non-significant between positive patients group and positive control group. Positive control group showed significant increasing in serum Ceruloplasmin level compared to negative control group and thatincreasing made serum Ceruloplasmin level in positive control group closely related to its level in positive patient group, while positive patient group showednon-significant increasing compare to negative patient group. Transferrin showed non-significant decreasing level in patient group compared with control for both groups of autoantibody. Present results may refer to inflammatory aspects of disease which associated with autoimmunity markers, moreover, the presence of autoantibodies increased the serum Ceruloplasmin level and decreased level of Transferrin even in healthy individuals. Present conclusion could help in the diagnosis and provide protection from developing disease.

Polymorphism of P-selectin (- 2123C/G, rs1800807 C/G) and IL-4 -1098 in a sample of Iraqi Diabetes Mellitus Type 2

“…Genetic polymorphism of P-selectin gene was investigated at the position -2123C/G, that corresponded to two alleles (G and C), which was presented with three genotypes (GG, GC and CC) in DMT2 patients and healthy control figure (1).The results showed that genotypes frequencies in control group was in a good agreement with Hardy-Weinberg equilibrium(HWE), no significant differences between the observed and expected frequencies in healthy Control, while a significant differences between the observed and expected frequencies in Patients with DMT2 that deviation from HWE may be because the small size of sample and blood relation Table (3).…”

“…Diabetes is a major public health problem because it is world's sixth cause of death. An inflammatory disease that associated with many inflammatory markers, which is a key for complications of vascular endothelial system, literally for high risk populations [1]. The disturbance of endothelial factors and circulating levels of adhesion molecules which are elevated in the sera of patients.…”