The Relationship between the COVID-19 Pandemic and Early Pregnancy Abortions

Arican, Cigdem Dicle

doi:10.24018/ejmed.2022.4.4.1445

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…Regarding blood groups and miscarriage rates, evidence to date shows that people in the O blood group have a reduced risk of acquiring COVID-19, whereas people in the A blood group are more likely to acquire the disease and develop a more severe form of the disease [27]. It is interesting to note that most women in this study who miscarried had an A Rh (+) blood group but without any statical correlation.…”

Section: Miscarriage Rates and Covid-19 Infectionmentioning

confidence: 60%

“…Additionally, among COVID-19 patients, patients with A blood groups experienced more severe histopathological symptoms, whereas patients with O blood groups and other blood groups had less frequent symptoms. The authors suggested that COVID-19 was implicated in early pregnancy abortions by designating a more susceptible population based on blood group since patients with COVID-19 and the A Rh (+) blood group had a higher risk of pregnancy abortion than persons with other blood types [27,28]. Table 1 summarizes the outcomes of the included studies.…”

Section: Miscarriage Rates and Covid-19 Infectionmentioning

confidence: 99%

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Association between COVID-19 Infection and Miscarriages, What We Really Know?

Chrysanthopoulos,

Potiris,

Drakaki

et al. 2023

Diseases

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Background: COVID-19 is a modern worldwide pandemic that affected and continues to affect millions of people around the world. Since the discovery that angiotensin-converting enzyme 2 (ACE2) is the binding site for COVID-19 to achieve cell entry, there has been a continuous debate about the effect of COVID-19 infection in first and second trimester abortions. The aim of this review is to investigate the impact of COVID-19 infection on the incidence of miscarriage. Furthermore, we seek to identify potential pathophysiological mechanisms of early pregnancy loss present in infected women. Methods: A literature review was conducted on different databases, including PubMed, Google Scholar, Ovid, Science Direct, Scopus, and Cochrane library, between 1 January 2020 and 31 August 2023. A total of 364 articles were identified and 32 articles were ultimately included in the review. Results: There are several case studies that provide evidence that early pregnancy loss is associated with COVID-19 infection. These findings are not further confirmed by the majority of systematic reviews and meta-analyses, which demonstrate that the total number of miscarriages do not differ significantly between infected and non-infected groups. Furthermore, there are also case reports that associate COVID-19 infection with late second trimester abortions. Conclusions: Given that the virus persists globally, it is important to gain a better understanding of its associated risks in the reproductive process, and larger, more homogeneous, and controlled studies are required to obtain more robust data that can be meta-analyzed to obtain an overview of this potential relationship.

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Section: Miscarriage Rates and Covid-19 Infectionmentioning

confidence: 60%

Section: Miscarriage Rates and Covid-19 Infectionmentioning

confidence: 99%