The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria

Xiang, Xun; Wu, Can; Zhang, Bo-Rui; Gao, Tao; Zhao, Jie; Ma, Long; Jiang, Feng-Lei; Liu, Yi

doi:10.1016/j.chemosphere.2017.06.091

Cited by 19 publications

(4 citation statements)

References 52 publications

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“…89 Intriguingly, the interaction between QDs and membrane proteins leads to the increase in mitochondrial membrane fluidity and the binding affinity of the QDs with pore-forming proteins is closely pertinent to size. 90 As aforementioned, ligands 91 and size 90 are two factors having capability to influence mitochondrial toxicity.…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

Wang

Tang

2018

IJN

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Quantum dots (QDs) are different from the materials with the micrometer scale. Owing to the superiority in fluorescence and optical stability, QDs act as possible diagnostic and therapeutic tools for application in biomedical field. However, potential threats of QDs to human health hamper their wide utilization in life sciences. It has been reported that oxidative stress and inflammation are involved in toxicity caused by QDs. Recently, accumulating research unveiled that disturbance of subcellular structures plays a magnificent role in cytotoxicity of QDs. Diverse organelles would collapse during QD treatment, including DNA damage, endoplasmic reticulum stress, mitochondrial dysfunction and lysosomal rupture. Different forms of cellular end points on the basis of recent research have been concluded. Apart from apoptosis and autophagy, a new form of cell death termed pyroptosis, which is finely orchestrated by inflammasome complex and gasdermin family with secretion of interleukin-1 beta and interleukin-18, was also summarized. Finally, several potential cellular signaling pathways were also listed. Activation of Toll-like receptor-4/myeloid differentiation primary response 88, nuclear factor kappa-light-chain-enhancer of activated B cells and NACHT, LRR and PYD domains-containing protein 3 inflammasome pathways by QD exposure is associated with regulation of cellular processes. With the development of QDs, toxicity evaluation is far behind its development, where specific mechanisms of toxic effects are not clearly defined. Further studies concerned with this promising area are urgently required.

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Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

Wang

Tang

2018

IJN

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“…286,287 Surface modification can affect the toxic effect of QDs by acting on different targets. [288][289][290][291] Compared with 2-mercaptoacetic acid-(TGA-) CdTe QDs, MPA-QDs have a stronger effect on mitochondrial MPT because TGA-CdTe QDs have better stability, so the amount of Cd 2+ released is lower and the toxicity is also lower, 288,290 which explains the difference in the damage of subcellular organelles by QD modification. Both carboxyl and amino-modified CdSe/ZnS QDs reduced the survival rate, hatching rate, and embryo movement of zebrafish, but COOH-CdSe/ZnS QDs were more toxic, which may be due to the higher affinity and release of carboxyl groups to embryos and larvae.…”

Section: Factors Affecting the Toxicity Of Qdsmentioning

confidence: 99%

New insights into the safety assessment of quantum dots: potential release pathways, environmental transformations, and health risks

Liu

Ding

Pang

et al. 2022

Environ. Sci.: Nano

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“…45 Our recent study showed that TGA-CdTe QDs and MPA-CdTe QDs could impair mitochondrial energy metabolism and affect mitochondrial lipid peroxidation. 46 The QDs could also induce membrane permeability transition (MPT) as evidenced by mitochondrial swelling, decreased membrane fluidity and collapsed membrane potential. However, TGA-CdTe QDs had a smaller effect on the MPT compared with MPA-CdTe QDs, which could be explained by the better stability of TGA-CdTe QDs.…”

Section: Cytotoxicitymentioning

confidence: 99%

The interactions of CdTe quantum dots with serum albumin and subsequent cytotoxicity: the influence of homologous ligands

Ren

Yin

et al. 2018

Toxicol. Res.

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With spreading applications of fluorescent quantum dots (QDs) in biomedical fields in recent years, there is increasing concern over their toxicity. Among various factors, surface ligands play critical roles. Previous studies usually employed QDs with different kinds of surface ligands, but general principles were difficult to be obtained since it was hard to compare these surface ligands with varied chemical structures without common features. Herein, the physicochemical properties of two types of CdTe QDs were kept very similar, but different in the surface ligands with mercaptoacetic acid (TGA) and 3-mercaptopropionic acid (MPA), respectively. These two types of homologous ligands only had a difference in one methylene group (-CH-). The interactions of the two types of CdTe QDs with bovine serum albumin (BSA), which was one of the main components of cell culture, were studied by fluorescence, UV-vis absorption, and circular dichroism spectroscopy. It was found that the fluorescence quenching of BSA by CdTe QDs followed a static quenching mechanism, and there was no obvious difference in the Stern-Volmer quenching constants and binding constants. The thermodynamic parameters of the two types of QDs were similar. BSA underwent conformational changes upon association with these QDs. By comparing the cytotoxicity of these two types of QDs, TGA-capped QDs were found to be less cytotoxic than MPA-capped QDs. Besides, in the presence of serum proteins, the cytotoxicity of the QDs was reduced. QDs in the absence of serum proteins had a higher internalization efficiency, compared with those in the medium with serum. To the best of our knowledge, this is a rare study focusing on surface ligands with such small variations at the biomolecular and cellular levels. These findings can provide new insights for the design and applications of QDs in complex biological media.

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The relationship between the length of surface ligand and effects of CdTe quantum dots on the physiological functions of isolated mitochondria

Cited by 19 publications

References 52 publications

Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

New insights into the safety assessment of quantum dots: potential release pathways, environmental transformations, and health risks

The interactions of CdTe quantum dots with serum albumin and subsequent cytotoxicity: the influence of homologous ligands

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