The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

Ferreira, Cristina Eustáquia; Fonseca, Adelaida Pallavicini; Silva, Ismael D.; Girão, Manoel Joâo Batista Castello; Sartori, Marair Grácio Ferreira; Castro, Rodrigo Aquino

doi:10.1016/j.ajog.2011.02.052

Cited by 20 publications

(36 citation statements)

References 20 publications

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“…Results were not available stratified by sex, and could not be included in quantitative synthesis. Subsequent reports used larger samples of Japanese women, 37 and Brazilian women 38 (Table 1), and looked specifically at the overactive bladder phenotype, finding a large effect size (pooled OR, 2.46; 95% CI, 1.67–3.60) (Figure 2), with no heterogeneity. Despite a lack of information about genotyping quality control (QC), and some risk of population stratification, this large effect size confers some protection from bias, providing Venice grading BBB, or moderate epidemiological credibility (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women

Cartwright

Kirby

Tikkinen

et al. 2015

American Journal of Obstetrics and Gynecology

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ObjectiveFamily studies and twin studies demonstrate that lower urinary tract symptoms and pelvic organ prolapse are heritable. This review aimed to identify genetic polymorphisms tested for an association with lower urinary tract symptoms or prolapse, and to assess the strength, consistency, and risk of bias among reported associations.Study DesignPubMed and HuGE Navigator were searched up to May 1, 2014, using a combination of genetic and phenotype key words, including “nocturia,” “incontinence,” “overactive bladder,” “prolapse,” and “enuresis.” Major genetics, urology, and gynecology conference abstracts were searched from 2005 through 2013. We screened 889 abstracts, and retrieved 78 full texts. In all, 27 published and 7 unpublished studies provided data on polymorphisms in or near 32 different genes. Fixed and random effects metaanalyses were conducted using codominant models of inheritance. We assessed the credibility of pooled associations using the interim Venice criteria.ResultsIn pooled analysis, the rs4994 polymorphism of the ADRB3 gene was associated with overactive bladder (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.7–3.6; n = 419). The rs1800012 polymorphism of the COL1A1 gene was associated with prolapse (OR, 1.3; 95% CI, 1.0–1.7; n = 838) and stress urinary incontinence (OR, 2.1; 95% CI, 1.4–3.2; n = 190). Other metaanalyses, including those for polymorphisms of COL3A1,LAMC1,MMP1,MMP3, and MMP9 did not show significant effects. Many studies were at high risk of bias from genotyping error or population stratification.ConclusionThese metaanalyses provide moderate epidemiological credibility for associations of variation in ADRB3 with overactive bladder, and variation of COL1A1 with prolapse. Clinical testing for any of these polymorphisms cannot be recommended based on current evidence.

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Section: Resultsmentioning

confidence: 99%

Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women

Cartwright

Kirby

Tikkinen

et al. 2015

American Journal of Obstetrics and Gynecology

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“…They have a major role in regulating smooth muscle tone, especially in the bladder . The hypofunction of this receptor causes disruption of the bladder detrusor muscle and dysfunction of the urinary tract …”

Section: Introductionmentioning

confidence: 99%

Exploring biomarkers in the overactive bladder: Alterations in miRNA levels of a panel of genes in patients with OAB

Fırat

Aybek

Akgün

et al. 2019

Neurourology and Urodynamics

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Aims It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma, which is potentially disease‐specific. Adrenergic and muscarinic pathways play an important role in voiding physiology. Alterations in the levels of miRNAs are thought to influence the regulation of these pathways at the molecular level. The aim of this study was to investigate the relationship of miRNAs with overactive bladder pathogenesis and to provide a new perspective to treatment approaches. Methods This study included patients with an overactive bladder (OAB) diagnosis and a healthy control group. All patients completed a validated OAB‐V8 questionnaire. The relative expression levels of 12 miRNAs were examined in plasma by PCR. Receiver operating characteristic (ROC) curves were generated to evaluate the diagnostic qualification of miRNAs. Results The relative expression levels of let‐7b‐5p, miR‐92a‐3p, miR‐98‐5p, miR‐142‐3p, and miR‐200c‐3p were significantly upregulated and miR‐139‐5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. Among the miRNAs, miR‐98‐5p provided the highest diagnostic accuracy alone (area under curve [AUC] = 0.79) in ROC analysis. The combination of miR‐98‐5p + miR‐139‐5p was seen to be a good indicator (AUC = 0.839). Conclusions These results suggest that alteration of the miRNA levels can be used as auxiliary parameters to explain the pathophysiology of OAB syndrome and could shed light on new treatment options.

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“…According to the inclusion criteria, 2 studies (Ferreira et al, 2011;Honda et al, 2013) were included in the meta-analysis and 78 were excluded. The flow chart of study selection is shown in Figure 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis

Zhang

Liu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we conducted a meta-analysis to explore the association between the Trp64Arg polymorphism and OAB risk. We examined 2 case-control studies, including a total of 149 OAB cases and 270 healthy controls. The meta-analysis results showed that the Arg allele of the β3-AR gene is positively associated with OAB susceptibility, while Arg allele carriers (Trp64Arg + Arg64Arg) showed positive associations with OAB. These results also demonstrated that the

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The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder

Cited by 20 publications

References 20 publications

Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women

Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women

Exploring biomarkers in the overactive bladder: Alterations in miRNA levels of a panel of genes in patients with OAB

Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis

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