The relationship between three X-linked genes and the risk for hypertension among northeastern Han Chinese

Li, Jinxin; Feng, Min; Wang, Yanli; Li, Yaodong; Zhang, Yanyi; Li, Lei; Xiong, Jian; Lu, Changzhu; Wang, Bin; Cheng, Zuheng; Tang, Baopeng; Niu, Wenquan

doi:10.1177/1470320314534510

Cited by 14 publications

(15 citation statements)

References 42 publications

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“…[ 6 ] Nevertheless, other results showed the rs2106809 was no significant deviation in either hypertensive or normotensive women in Chinese Han population. [ 11 , 12 ] The possible reasons may be attributed to that the observed population have different ethnicity and race, and come from regions with different natural environment. Therefore, to more precisely elucidate the role of ACE2 SNPs in EH, further research is necessary to determine a wider range of ACE2 polymorphic loci associated with EH in population who come from different regions and ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender

et al. 2018

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“…Only 5 polymorphisms in apelin/APJ system were significantly associated with hypertension, obesity and onset age of hypertension. The results of this pilot study were subsequently validated by several association studies [10, 12, 15, 23]. However, significant findings are not often reproducible, and no consensus has been reached yet.…”

Section: Discussionmentioning

confidence: 66%

“…In fact, this gender-specific contribution may reflect the impact of some genes on sex chromosomes, such as apelin and angiotensin-converting enzyme 2 in X chromosome [24]. Several lines of evidence have suggested a heterogeneous contribution of these X-linked genes to the pathogenesis of hypertension [15, 25–27]. In spite of the null association of apelin gene with hypertension in this study, we observed that SBP differed significantly between two homozygous genotypes of rs3761581 in apelin gene.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, apelin is a peptide hormone and its coded gene is mapped on X-chromosome. Growing genetic data on sex chromosomes emphasize the gender-specific role in the pathogenesis of hypertension [15, 16]. To shed more light on this issue, we decided to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population.…”

Section: Introductionmentioning

confidence: 99%

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A promoter polymorphism in APJ gene is significantly associated with blood pressure changes and hypertension risk in Chinese women

Sun

Zhao

et al. 2016

Oncotarget

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The aim of this study was to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population. This is a population-based case-control study, including 650 hypertensive patients and 645 normotensive controls. Data were analyzed by STATA and Haplo.Stats. The genotype distributions of 5 study polymorphisms were in Hardy-Weinberg equilibrium in both genders. The rs7119375 and rs10501367 were completely linked. The genotypes (P = 0.001) and alleles (P < 0.001) of rs7119375 differed significantly between patients and controls in women. Carriers of rs7119375-AA genotype had significant higher systolic blood pressure (SBP) than carriers of rs7119375-GG genotype in both patients and controls of female gender (P < 0.01). Moreover, carriers of rs7119375-A allele were 1.80 times more likely to develop hypertension relative to carriers of rs7119375-GG genotype after adjusting for age, body mass index and glucose (odds ratio: 1.80; 95% confidence interval: 1.03–3.16; P = 0.040). Further allele combination analysis supported the leading contribution of rs7119375 to hypertension risk. Our findings demonstrated that the mutation of promoter polymorphism rs7119375 in APJ gene was significantly associated with elevated SBP and increased hypertension risk in Chinese women.

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“…15 One study based on Eastern China (Shanghai) population did not find a significant relationship of rs56204867 and hypertension in both males ( p =0.07) and females ( p =0.4621). 16 In the Northeastern Chinese population (Heilongjiang), one study demonstrated the significant association between rs56204867 and hypertension in both females ( p =0.001) and males ( p =0.001), 20 which was absent in another study ( p =0.922 for males and p =0.251 for females). 13…”

Section: Introductionmentioning

confidence: 94%

The association between apelin polymorphisms and hypertension in China: A meta-analysis

Wang

Liu

Jia

et al. 2019

J Renin Angiotensin Aldosterone Syst

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Introduction:Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.Materials and methods:Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model.Results:The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82–1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89–1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46–1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86–1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86–1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81–1.79).Conclusion:This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension.

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The relationship between three X-linked genes and the risk for hypertension among northeastern Han Chinese

Abstract: Our findings demonstrate that genetic defects in AGTR2 and apelin genes by themselves may play an independent leading role in determining susceptibility to hypertension in both genders.

Cited by 14 publications

References 42 publications

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender

A promoter polymorphism in APJ gene is significantly associated with blood pressure changes and hypertension risk in Chinese women

The association between apelin polymorphisms and hypertension in China: A meta-analysis

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