The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary  Hypothyroidism

Sulejmanović, Maja; Begić, Amela; Mujaric-Bousbia, Fatima; Salkić, Sabina; Ramaš, Almedina

doi:10.5455/medarh.2020.74.359-362

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…These findings indicate that a lack of vitamin D may have an impact on AITD pathogenesis. The results from a case-control study conducted by Sulejmanovic et al confirm the findings from the aforementioned studies that had significantly lower levels of vitamin D in AITD patients [ 14 ]. This result was confirmed by Tamer et al [ 22 ].…”

Section: Reviewsupporting

confidence: 78%

Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review

Khozam¹,

Sumaili²,

AlFlan³

et al. 2022

Cureus

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Despite recent evidence that low serum 25-hydroxyvitamin D (25(OH)D) levels and deflects may influence the emergence of autoimmune thyroid disorders (AITD), the relationship between vitamin D deficiency and Graves’ disease (GD) and Hashimoto's thyroiditis (HT), which comprise AITD, remains unclear. We retrieved studies that described vitamin D association with HT and GD from PubMed/Medline, Google Scholar, and the Cochrane Library. We included research studies that compared vitamin D levels and deficiency or sufficiency between AITD cases such as HT and GD cases and control subjects. The final assessment comprised 11 studies that recruited 1952 AITD cases (HT and GD) that were published between 2011 and 2021; these were included in the final review. All the included studies were observational, and more precisely, case-control studies that recruited healthy subjects as well as controls. The majority of the studies reviewed indicated that HT and GD patients have a greater prevalence of vitamin D deficiency or low serum 25 (OH)-D levels. Two studies failed to establish an association between vitamin D deficiency and HT and GD disease. In conclusion, vitamin D deficiency or insufficiency can increase the rate of autoimmune diseases such as HT and GD. Randomized controlled trials with a longer follow-up period are needed to confirm the causal relationship between autoimmune thyroid disorder and vitamin D and to provide more reliable insights into the relevance of treatment effects of vitamin D therapy or supplementation.

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Section: Reviewsupporting

confidence: 78%

Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review

Khozam¹,

Sumaili²,

AlFlan³

et al. 2022

Cureus

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“…Fang et al 29 revealed that thyroid autoantibody (TPOAb and TgAb) positivity was closely associated with vitamin D deficiency, suggesting the involvement of vitamin D in the pathogenesis of autoimmune thyroid diseases. Similarly, Sulejmanovic et al 30 found that vitamin D deficiency was correlated with the presence of antithyroid antibodies. In the present study, we found that the presence of TPOAb and TgAb positivity was significantly higher in patients with 25(OH)D deficiency than in those without it, consistent with the findings from previous studies in other populations.…”

Section: Discussionmentioning

confidence: 87%

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Quan¹,

Bi²

2023

DMSO

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Purpose It is unknown whether there is an association between 25-hydroxyvitamin D (25(OH)D) level and thyroid disease in postmenopausal women with type 2 diabetes. This study aimed to evaluate the relationship between blood 25(OH)D levels and thyroid function in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study involved Chinese postmenopausal women who presented to our diabetes clinic from March 2021 to May 2022 and were diagnosed with T2DM collected via a convenience sampling method. Blood samples were obtained from each patient to detect serum thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and 25(OH)D levels. Deficiency was defined as a 25(OH)D < 20 ng/mL. Comparative analysis was via t -test or chi-square test. Pearson correlation was then used to estimate the relationship between different thyroid function parameters and 25(OH)D. Multivariate logistic regression analysis was used to explore potential risk factors for 25(OH)D deficiency. Results In total, 157 out of 230 participants (68.26%) had 25(OH)D deficiency. Compared with patients with normal 25(OH)D levels, patients with 25(OH)D deficiency had shorter medical histories of diabetes mellitus (DM, p = 0.001) and higher rates of hyperthyroidism ( p = 0.007), hypothyroidism ( p < 0.001), TPOAb positive ( p < 0.001) and TgAb positive ( p < 0.001). Correlation analysis revealed that TSH ( r = −0.144, p = 0.030), FT4 ( r = −0.145, p = 0.029), TPOAb ( r = −0.216, p = 0.001) and TgAb ( r = −0.150, p = 0.024) levels were correlated with serum 25(OH)D levels. Further multivariable logistic regression analyses suggested that the length of DM history, presence of hyperthyroidism, presence of hypothyroidism and positive TPOAb were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM. Conclusion Hyperthyroidism, hypothyroidism and TPOAb positivity were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.

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“…The classification of BMI was defined as follows: underweight (<18.5), Normal weight (≥18.5, <25), overweight (≥25, <30) and obese (≥30) ( 13 ). Patients with the following conditions were defined as “hypertension”: systolic blood pressure ≥ 140 or/and diastolic blood pressure ≥ 90mmHg or having a history of hypertension ( 15 ). Participants with one of the following conditions were considered to have diabetes: a history of diabetes, use of insulin or oral hypoglycemic agents ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

Association between serum vitamin D levels and sensitivity to thyroid hormone indices: a cross-sectional observational study in NHANES 2007–2012

Chen,

Yang,

Guo

et al. 2023

Front. Endocrinol.

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ObjectiveWe designed this study to determine whether there is a link between vitamin D levels and sensitivity to thyroid hormone and to provide a new perspective for studying the relationship between vitamin D and thyroid disease.MethodsOur study included 8,126 participators from the National Health and Nutrition Examination Survey (NHANES) database between 2007 and 2012. We used weighted multiple linear regression models to enquire the connection between serum vitamin D levels and thyroid hormone sensitivity indicators, including the following: Thyroid-stimulating hormone index (TSHI), Free Triiodothyronine/Free thyroxine (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), and Thyrotroph Thyroxine Resistance Index (TT4RI). Finally, we used constrained cubic splines to explore possible nonlinear relationships. All data cleaning and statistical analyses were performed using R software.ResultsThe final Results were reached after adjusting for various confounding factors. We found a U-shaped relationship between TFQI and serum vitamin D, and the lowest TFQI appeared when the serum vitamin D concentration was 25.77ng/ml. However, an inverse U-shaped relationship was found between FT3/FT4 and vitamin D levels. When the serum vitamin D concentration was 25.43ng/ml, the ratio of FT3/FT4 was the highest.ConclusionIn the US population, our study concluded that FTQI and FT3/FT4 were U-shaped or inverse-U-shaped with serum vitamin D levels respectively after several adjustments. Therefore, FTQI and FT3/FT4 are considered indicators of the complex relationship between thyroid hormone resistance and vitamin D metabolism. In the future, more complex prospective investigations are needed to confirm these findings and find a causal link between them.

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The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism

Cited by 11 publications

References 17 publications

Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review

Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review

Relationship Between Serum 25-Hydroxyvitamin D Deficiency and Thyroid Disease in Postmenopausal Women with Type 2 Diabetes Mellitus

Association between serum vitamin D levels and sensitivity to thyroid hormone indices: a cross-sectional observational study in NHANES 2007–2012

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