The Relationship Between Thyroid Function and Serum Levels of Angiopoietin-Like Protein 3, Leptin and Visfatin

Abstract

Background.Abnormal thyroid function is accepted to be associated with disordered production of hormones released by adipose tissue.Objective. We aimed to investigate the relationship between thyroid functions and adipocytokines as leptin and visfatin and Angiopoietin-like Protein 3 (ANGPTL), a secretory protein that affects adipocity in patients with thyroid dysfunction.Methods. Twenty-seven patients with hyperthyroidism, 27 patients with hypothyroidism and 31 euthyroid subjects as control group were selected. Serum TSH, fT3, fT4, fasting glucose, lipid profile, ANGPTL, visfatin, leptin, insulin levels were determined.Results. ANGPTL and visfatin were significiantly different in hypothyroid group when compared to other groups. (p<0.0167) ANGPTL was positively correlated with TSH and leptin. Leptin was correlated with insulin and ANGPTL positively. Visfatin, positively correlated with TSH, total cholesterol, LDL-C and negatively correlated with fT3 and fT4.Conclusion. Serum ANGPTL may be increased because of lipid abnormalities in hypothyroid patients. Visfatin is thought as a partly mediator to the effect of hyper/ hypothyroidism on several metabolic parameters. We suggest that the release of Visfatin is regulated by thyroid hormones. The effect of thyroid dysfunction on production and release of adipocytokine is not yet clarified.

Does euthyroid mean healthy? Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism.

“…We have recently found visfatin/NAMPT overexpression in thyroid cancers and in thyroid glands of patients with Graves' orbitopathy, as well as in their leukocytes, supporting anti-apoptotic and proinflammatory properties of this adipocytokine (6)(7)(8). However, previous studies on changes in visfatin serum levels in different thyroid dysfunctions brought inconclusive results, what might be partially explained by the heterogenous etiology of thyroid disorders (9)(10)(11)(12)(13). We already reported that visfatin serum concentration in hypothyroidism is associated with free thyroid hormones and antithyroperoxidase antibodies, while in hyperthyroidism visfatin mainly correlates with fat content with minor effect of thyroid autoimmunity (14,15) .…”

Effect of restoration of euthyroidism on visfatin concentrations and body composition in women

“…In addition, visfatin serum concentrations in hypothyroidism is associated with free thyroid hormones and antithyroperoxidase antibodies, while in hyperthyroidism visfatin mainly correlates with fat content with minor effect of thyroid autoimmunity (14,15). However, previous studies on changes in visfatin serum concentrations in thyroid disorders brought inconclusive results, which might be partially explained by the heterogenousity of thyroid disorders (16)(17)(18)(19)(20).…”

Determinants of Visfatin/NAMPT Serum Concentration and its Leukocyte Expression in Hyperthyroidism

“…There are a few relatively small studies evaluating visfatin serum levels in hyperthyroidism, but their results are inconclusive [10][11][12][13][14][15]. Caixas et al reported tendency for elevation of circulating visfatin in hyperthyroid group of non-homogenous etiology (24 patients with Graves' disease and 1 with toxic nodular goiter) [11].…”

“…Also, lowering of visfatin serum concentration was observed in rats with hyperthyroid state induced with L-thyroxine administration [14]. Recently, Yildiz et al did not find any differences between visfatin levels in 27 hyperthyroid patients and healthy controls [15]. These studies were focused on the association between visfatin/NAMPT and parameters of thyroid function, insulin resistance, and anthropometric variables, and they did not take into consideration thyroid autoimmunity.…”