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Background.Abnormal thyroid function is accepted to be associated with disordered production of hormones released by adipose tissue.Objective. We aimed to investigate the relationship between thyroid functions and adipocytokines as leptin and visfatin and Angiopoietin-like Protein 3 (ANGPTL), a secretory protein that affects adipocity in patients with thyroid dysfunction.Methods. Twenty-seven patients with hyperthyroidism, 27 patients with hypothyroidism and 31 euthyroid subjects as control group were selected. Serum TSH, fT3, fT4, fasting glucose, lipid profile, ANGPTL, visfatin, leptin, insulin levels were determined.Results. ANGPTL and visfatin were significiantly different in hypothyroid group when compared to other groups. (p<0.0167) ANGPTL was positively correlated with TSH and leptin. Leptin was correlated with insulin and ANGPTL positively. Visfatin, positively correlated with TSH, total cholesterol, LDL-C and negatively correlated with fT3 and fT4.Conclusion. Serum ANGPTL may be increased because of lipid abnormalities in hypothyroid patients. Visfatin is thought as a partly mediator to the effect of hyper/ hypothyroidism on several metabolic parameters. We suggest that the release of Visfatin is regulated by thyroid hormones. The effect of thyroid dysfunction on production and release of adipocytokine is not yet clarified.

Twelve animals (26+/-5 kg) were subjected to the study. In this experimental study, the authors used prostacyclin to inhibit the toxic metabolite release during protamine administration. Animals were divided into two equal groups. Six animals received prostacyclin (the prostacyclin group), and the other six animals did not receive any additional treatment (the control group). All cardiac output and biochemical measurements were evaluated at baseline; before cardiopulmonary bypass; and at 5, 30, and 60 minutes after protamine administration. The measured cardiac index showed that the hearts treated with prostacyclin had satisfactory preservation of left ventricular function. Metabolic and biochemical data showed that the tumor necrosis factor level was raised significantly in the control group (20.75+/-2.2 in the control group and 13.75+/-2.5 pg/mL in the prostacyclin group). Also, E and P selectin levels were elevated in the control group, but this change was less marked in the prostacyclin group. In addition, the intracellular adhesion molecule-1 (ICAM-1) level was significantly higher in the control group than in the prostacyclin group (9.26+/-2.13 in the control group and 5.13+/-1.66 ng/mL in the prostacyclin group). The authors observed that prostacyclin inhibited the toxic mediator release during heparin reversal with protamine. This inhibition is one way of protecting the myocardium reserves from protamine cardiotoxicity.

Eighteen rabbit hearts were arrested for 3 hours with cardioplegic solution at 4°C, followed by reperfusion with oxygenated perfusion solution at 37°C for 2 hours. Six control hearts received no drug during arrest or reperfusion (group 1). Six hearts received 3 mg•L -1 aminophylline during the arrest period (group 2). Six hearts received 3 mg•L -1 aminophylline during the reperfusion period (group 3). Effects of aminophylline were evaluated in terms of the pressure-volume relationship, coronary flow, myocardial oxygen extraction, and lactate release before cardioplegic arrest and after 1 and 2 hours of reperfusion. End-diastolic pressure at constant volume after 2 hours of reperfusion was 19 ± 2.63 mm Hg in group 1, 14 ± 1.7 mm Hg in group 2, and 19 ± 2.55 mm Hg in group 3 (p < 0.05 for group 2 versus groups 1 and 3). End-systolic pressure at constant volume after 2 hours of reperfusion was 81 ± 3.55 mm Hg in group 1, 90 ± 2.95 mm Hg in group 2, and 84 ± 3.47 mm Hg in group 3 (p < 0.05 for group 2 versus groups 1 and 3). Oxygen extraction was significantly higher and release of lactate was significantly lower in group 2 compared to groups 1 and 3. The results indicate that aminophylline administration during cardioplegic arrest improved systolic and diastolic function and had a beneficial effect on metabolic recovery.