The Relationship between Thyroid Hormones, Metabolic Syndrome and HOMA-IR in People with Obesity or Overweight

Abstract

Objective: In the literature the data about the relationship between thyroid hormone (TH) levels and Metabolic Syndrome (MetS) components are conflicting. Our aim was to evaluate the associations between THs and MetS as well as individual components of MetS and homeostatic model assessment of insulin resistance (HOMA-IR) in euthyroid people with obesity and overweight. Materials and methods: Adult patients who presented to Family Medicine Outpatient Clinics of a tertiary hospital between May 2019 and December 2019 with the intention of weight loss were enrolled in this cross-sectional, descriptive study. The data including height, weight, waist circumference, hip circumference, blood pressure (BP), fasting blood glucose (FBG), total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), insulin, HOMA-IR, and HbA1c were analyzed. Results: A total of 175 patients, 135 (77.1%) female, 40 (22.9%) male (mean age: 40.8 ± 13.1 years), without known thyroid dysfunction were included. A total of 86 were overweight and 89 were obese. Fifty-nine (33.7%) of the study participants were diagnosed with MetS. Subjects with MetS had significantly higher level of fT3 even within the normal range (p = 0.039). When TSH, fT4 and fT3 values were compared with other metabolic components in the group with MetS, a significant positive correlation was found only between fT4 level and HOMA-IR (Rho = 0.316, p = 0.026). Conclusions: MetS was associated with high normal fT3suggesting differential thyroid hormone metabolism in

Study of The Relation Between Thyroid Function and Metabolic Syndrome in Elderly Patients

“…In older patients who are just beginning to develop type 2 diabetes, higher TSH levels may have a role in the development of insulin resistance. Furthermore, Emiroğlu et al [17] reported that participants with MetS had a considerably greater level of fT3 than those without MetS, which is consistent with the current findings. However, they did not find any significant correlation between TSH and FT4 and MetS, which contrasts with our findings.…”

“…Given that a major component of metabolic syndrome is hypertension, it was expected that patients with MetS would have significantly higher blood pressure. Congruent with the present investigation, Emiroğlu et al [17] demonstrated that individuals with MetS exhibited noticeably elevated SBP and DBP in contrast to those without the condition. In keeping with the current investigation, Huo et al's [18] findings showed that the incidence of MetS rose in tandem with blood pressure increases.…”

“…Santana et al [13] found that senior patients with MetS had significantly greater FBG and HBA1c than those without MetS, which is consistent with the findings of the current investigation. Furthermore, participants with MetS exhibited considerably higher FBG than those without MetS, according to Emiroğlu et al [17]. Furthermore, older individuals with MetS had considerably higher HOMA-IR than senior patients without MetS, according to Kazukauskiene et al [21].…”

Incidencia de síndrome metabólico en pacientes con hipotiroidismo subclínico, Enero 2019 Julio 2022 en Ciudad Juárez

“…El hipotiroidismo subclínico llega a afectar hasta al 10% de la población adulta mundial (18). Estas se asocian con mayor frecuencia de enfermedad cardiovascular, diabetes mellitus 2 y aumento de la mortalidad; así como anomalías relacionadas con riesgo metabólico y niveles anormales de insulina (19). En el presente estudio, la incidencia de síndrome metabólico en los pacientes con diagnóstico de hipotiroidismo subclínico fue de un 27.66%, en un estudio realizado en Sevilla norte, España.…”

Association Between Selenium and Circulating Adipokine Levels in Patients with Polycystic Ovary Syndrome

“…were measured with an enzyme-linked immunosorbent assay (ELISA) kit (DiaMetra, Milano, Italy) according to the manufacturer's instructions. Insulin resistance was assessed by calculating the HOMA-IR according to the suggested formula [30]. Serum levels of adiponectin, leptin, resistin, visfatin and omentin-1 were measured using ELISA kits (Bioassay Technology Laboratory, Shanghai Korean Biotech, Shanghai City, China).…”