The relationship between toxoplasmosis and different types of human tumors

Abstract

Introduction: Toxoplasma gondii is an intracellular protozoan that may disrupt the traditional cell barriers against cancer, allowing the accumulation of oncogenic mutations over time. Our research aimed to explore the relationship between T. gondii infection and tumor development.
 Methodology: The anti-T. gondii IgG and IgM antibodies were tested for156 patients with tumors (51 with breast cancer, 20 with hepatoma, 20 with larynx carcinoma, 20 with squamous cell carcinoma of bone, 16 with lymphoma, 13 with brain tumor, 4 with bladder cancer and 12 with benign uterine tumor) and 90 healthy controls by using electrochemiluminescence immunoassay. Tissue specimens were collected from T. gondii seropositive cases for histological and immunohistochemistry (IHC) examinations. Results: The seroprevalence of human toxoplasmosis in the Sharkia Governorate, Egypt is significantly correlated with various types of tumors: breast cancer in 49 subjects (96.1%), and squamous cell carcinoma of bone in 16 subjects (80%). It was also present in nine cases of brain tumors. Anti-Toxoplasma IgG was detected in seven cases of liver tumors and one-quarter of bladder cancer. The anti- Toxoplasma IgM was present in three patients with benign uterine tumors, one patient with a bone tumor and two patients with breast cancer. Toxoplasma cysts were detected in immunostained brain sections.
 Conclusion: The correlation between T. gondii infection and tumors was established by this study indicating a significant emerging role of human toxoplasmosis in the etiology or existence of particular types of tumors.

Molecular and Immunological test for detection of Toxoplasma gondii in pregnant women and patients with prostate cancer

“…Retinochoroiditis; Pneumonia as well as other spread basic contaminations, can in like manner be found, anyway are not as fundamental as encephalitis in low immunity patients (2) . The harm can reactivate inactive Toxoplasmosis gondii ailment during the treatment of cancer (3) . Many type of malignancies, including multiple myeloma; lymphoma and leukemia that can reactivate toxoplasmosis (2) .…”

“…The incitement of the safe reaction by T. gondii or hindrance of angiogenesis may clarify the biologic premise of these perceptions. In creature, it has been demonstrated that specific parasites or parasitic mixes had the option to repress disease growth (3) . Nevertheless, in low immunity people, reactivation of the idle T. gondii bradyzoites transformed to the proliferative tachyzoite stage that can cause toxoplasmic encephalitis (TE) (4) .…”

Estudio multicéntrico, de seroprevalencia de IgG Toxoplasma gondii en niños con cáncer de la red del Programa Infantil Nacional de Drogas Antineoplásicas en la Región Metropolitana, Chile

“…Este trabajo constata que, pese a que casi la mitad de las muestras correspondieron a mujeres, la proporción de mujeres positivas para IgG T. gondii fue significativamente mayor que la encontrada en los hombres, hallazgo concordante con otros estudios en adultos con cáncer 12,16,17 y distinto a lo encontrado en un estudio en Estados Unidos de América realizado entre 2009 y 2010, con una prevalencia mayor en hombres (p < 0,05) 18 . Estas variaciones de prevalencia entre países podrían deberse a diferencias socio-culturales y de costumbres, tales como el cuidado de las mascotas, particularmente los gatos, el cuidado del jardín, la manipulación de carne cruda o parcialmente cocida, limpieza de frutas y verduras, entre otras actividades domésticas 12,17 .…”

Biological risk assessment of miltefosine in concomitant infection with opportunistic toxoplasmosis

“…Thus, Due to the close association between T. gondii prevelance and cancer [36,37], and T. gondii prevelance and leishmaniasis [38] which are both fatal, clinicians should be more careful with toxoplasmainfected cancer or leishmanial patients receiving miltefosine. Moreover, parasitological surveys of miltefosine-receiving patients should be regularly carried out, aiming at preventing the possibility of severe accidental toxoplasmosis during therapy.…”