The Relationship between Tumor Necrosis Factor-α Polymorphisms and Hepatitis C Virus Infection: A Systematic Review and Meta-Analysis

He, Jun; Pei, Xiaohua; Xu, Wei; Wang, Cuiyu; Zhang, Xiaoli; Wu, Jianqing; Zhao, Weihong

doi:10.3109/0886022x.2011.605537

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…A growing body of evidence proves that in chronic HCV infection, TNF-α plays a role in the inflammatory response to HCV, including the mediation of apoptosis, but it does not play a part in the control of HCV replication [18,19]. In addition, it has been shown that TNF-α polymorphisms might have no effect on susceptibility to HCV infection and virus clearance [20]. On the other hand, a direct correlation between TNF-α and serum alanine aminotransferase (ALT) levels was found in patients with chronic HCV infection [21].…”

Section: Chronic Viral Hepatitismentioning

confidence: 99%

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

Lopetuso

Mocci

Marzo

et al. 2018

IJMS

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Anti-tumor necrosis factor (TNF)-α agents represent an effective treatment for chronic inflammatory diseases. However, some concerns about their potentially undesirable effects on liver function have been reported. On the other hand, evidence of their therapeutic effects on certain liver diseases is accumulating. Many data showed the safety of anti-TNF-α in patients with chronic hepatitis B and C and in liver transplanted patients even if a strict follow-up and prophylaxis are recommended in well-defined subgroups. On the other side, anti-TNF-α-induced liver injury is not a rare event. However, it is often reversible after anti-TNF-α withdrawal. Anti-TNF-α agents have been tested in advanced stages of severe alcoholic hepatitis and non-alcoholic fatty liver disease. Limited data on the efficacy of anti-TNF-α in patients with autoimmune hepatitis and primary biliary cholangitis are also available. In this review, we explored the hepatic safety concerns in patients receiving anti-TNF-α agents with and without pre-existent hepatic diseases. In addition, the available evidence on their potential benefits in the treatment of specific hepatic diseases is discussed.

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Section: Chronic Viral Hepatitismentioning

confidence: 99%

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

Lopetuso

Mocci

Marzo

et al. 2018

IJMS

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“…Few studies found both -238 and -308 loci significantly important in correlation with diseases [41–43]. Many studies found both -308 and -238 loci nonsignificant when seeking for correlation between clinical manifestations and genetic materials [15, 44–47]. When comparing locus -308 with other loci (-238, -836), the correlation of locus -308 with other diseases such as Guillain-Barré syndrome [48], tuberculosis [49], and ANCA-associated vasculitis [50] has recently been approved.…”

Section: Introductionmentioning

confidence: 99%

The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

Tayebi

Ashraf

2012

Hepatitis Research and Treatment

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Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association.

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“…Besides, the distributions of TNF-α-308, -238 A/G alleles were also not significantly different between the persistent infection group and the spontaneous clearance group. It is well known that certain diseases such as psoriasis and concomitant HCV infection are succesfully treated with anti-TNF therapy without signs of reactivation of HCV (31,32). Therefore, we conclude that TNF-α-308 (rs3091256) polymorphism may not really have any effect on treatment response.…”

Section: Discussionmentioning

confidence: 82%

TNF-alpha 308 SNP Rs3091256 GG Genotype is Strongly Associated with Fibrosis in Patients with Chronic Hepatitis C

Günal¹,

Yalçin²,

Çelik³

et al. 2017

vhd

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ÖZObjective: We aimed to review the influence of host genetic factors on the clinical course, treatment response as well as fibrosis progression in patients with viral hepatitis C genotype 1. Materials and Methods: Ninety-five patients with chronic hepatitis C virus (HCV) infection and 97 controls were enrolled. The patients received pegylated interferon (Peg-IFN)+ribavirin therapy for 48 weeks and were followed up for the next 48 weeks. Aspartat aminotransferase/platelet ratio (APRI) was used to detect liver fibrosis DNA specimens were extracted from the peripheral blood mononuclear cells and the tumor necrosis factor-alpha (TNF-α) 308 rs3091256 was genotyped by the polymerase chain reactionrestriction fragment length polymorphism method. Results: All patients included in the study were infected with HCV genotype 1. of the 95 HCV-positive patients, spontaneous viral clearence was observed in 25.5%, rapid viral response in 44.2%, early viral response in 91.8%, and sustained viral response was found in 73.3% of patients. The allele and genotype were not significant between patients and controls. There was no significant difference in virologic response as well. However, TNF-α-308 single nucleotide polymorphisms (SNP) rs3091256 GG genotype was strongly associated with fibrosis and alanine aminotransferase (ALT) levels (p=0.006 and p=0.017, respectively). Conclusion: TNF-α-308 polymorphisms may reveal different results among countries. Patients having SNP rs3091256 GG are prone to have higher ALT levels and fibrosis score but have better treatment outcome.

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The Relationship between Tumor Necrosis Factor-α Polymorphisms and Hepatitis C Virus Infection: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 41 publications

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

TNF-alpha 308 SNP Rs3091256 GG Genotype is Strongly Associated with Fibrosis in Patients with Chronic Hepatitis C

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