The relationship between visfatin, liver inflammation, and acute phase reactants in chronic viral hepatitis B

Abstract

Chronic viral hepatitis B (CHB) is an important cause of morbidity and mortality. Adipokine stimulation might play an important role in the pathogenesis of chronic inflammation. The aim of this study was to evaluate serum visfatin concentrations and the relationship between visfatin, fibrosis, liver inflammation, and acute phase reactants in CHB patients.The sampling universe of the study consisted of 41 CHB patients and 25 healthy controls. All patients had positive hepatitis B surface antigen (Hepatitis e antigen (HBeAg) positive n: 7, n: 34 HBeAg negative) for at least 6 months and detectable serum HBV DNA. Serum visfatin concentrations were significantly higher in the CHB patients [18.0 ± 10.9 ng dL(-1)] than in the healthy controls [9.4 ± 1.6 ng dL(-1)] [P < 0.001]. On the other hand, fibrinogen and haptoglobin concentrations were significantly lower in CHB patients. A strong negative correlation was observed between serum visfatin concentration, haptoglobin, and fibrinogen levels; however, there was no significant correlation between visfatin, glucose, alanine aminotransferase, aspartate aminotransferase, BMI, Knodell score, fibrosis score, hepatitis B virus DNA, sedimentation, and C-reactive protein. Visfatin concentrations were elevated and visfatin was negatively correlated with haptoglobin and fibrinogen levels in CHB patients.

The evaluation of serum biomarkers in patients with sarcoidosis: Can visfatin be a new biomarker for sarcoidosis?

“…In a study evaluating the correlation of elevated serum visfatin levels and inflammatory markers (hs-CRP, IL-6, TNF-α, waist circumference, TG, and BMI) in obese children, visfatin was only correlated with BMI and IL-6; no significant correlation with hs-CRP was observed [30]. Similarly, serum visfatin levels, CRP and sedimentation rate showed no correlation in patients with chronic viral hepatitis B and metabolic syndrome [31,32]. We found no statistical difference in visfatin levels between steroid-naive patients and patients currently receiving steroid treatment.…”

Serum Visfatin Levels in Ulcerative Colitis

“…Visfatin is a recently identified adipokine, secreted primarily by visceral WAT. It is also produced by various cells, and levels are elevated in the systemic circulation of patients with various diseases such as Behçet's disease, rheumatoid arthritis, chronic viral hepatitis B, nonalcoholic fatty liver disease and cardiovascular disease .…”

Porphyromonas gingivalis and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

“…In their study, Nogueira et al 26 reported Fn to increase the visfatin expression. Some virus‐induced systemic diseases are also reported to be associated with elevated visfatin levels 28 , 29 . In some in vitro studies, it was found that viral induction resulted in an increased visfatin release, which is probably attributable to the protective effect of visfatin against the viruses 30 .…”