The relationship between volumetric brain changes and cognitive function: A family study on schizophrenia

Toulopoulou, Timothea; Grech, Anton; Morris, Robin G.; Schulze, Katja; McDonald, Colm; Chapple, Ben; Rabe‐Hesketh, Sophia; Murray, Robin M.

doi:10.1016/j.biopsych.2004.06.026

Cited by 77 publications

(49 citation statements)

References 45 publications

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“…However, ventricular volumes have been related to tests requiring motor speed, such as TMT B , and enlargement of the ventricular system has been demonstrated in diseases typically associated with motor symptoms, such as Parkinson´s disease (Dalaker et al, 2010). Surprisingly, enlarged ventricular size related significantly to poorer executive functioning only in bipolar disorder, which was unexpected since previous studies have demonstrated this relationship in schizophrenia Toulopoulou et al, 2004), but could be of importance, since both ventricular enlargements and executive dysfunction are frequently implicated in bipolar disorder Kempton et al, 2008).…”

Section: Subcortical Structuresmentioning

confidence: 49%

“…From the literature one would expect the left hippocampus to be associated with verbal memory (Toulopoulou et al, 2004), whereas the right hippocampus has been shown to be important for spatial memory functioning (Antonova et al, 2004).…”

Section: Subcortical Structuresmentioning

confidence: 99%

“…In schizophrenia, hippocampus and amygdala volumes Gur et al, 2000;Killgore et al, 2009), and cerebellar volumes (Toulopoulou et al, 2004) have been related to performance on memory tasks. Striatal and thalamic volumes (Crespo-Facorro et al, 2007b) have been related to executive functioning and attention.…”

Section: Subcortical Regionsmentioning

confidence: 99%

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Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Hartberg

Lawyer

Nyman

et al. 2010

Psychiatry Research: Neuroimaging

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Section: Subcortical Structuresmentioning

confidence: 49%

Section: Subcortical Structuresmentioning

confidence: 99%

See 1 more Smart Citation

Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Hartberg

Lawyer

Nyman

et al. 2010

Psychiatry Research: Neuroimaging

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“…Studies that have been conducted in twins and non-twin relatives report associations between verbal memory and hippocampal volume in both patients and relatives [5,7] .…”

mentioning

confidence: 99%

“…Similar to structural brain changes, functional brain measures have been proposed as important endophenotypes for further study. For example, cognitive deficits, especially impaired executive control functions, are promising candidates [5] .…”

mentioning

confidence: 99%

Cognitive Performance and Grey Matter Density in Psychosis: Functional Relevance of a Structural Endophenotype

Habets

Krabbendam²,

Hofman³

et al. 2008

Neuropsychobiology

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Background: Structural brain changes and cognitive impairments have been identified as indicators of genetic risk for schizophrenia. However, the pattern of associations between such structural and functional liability markers has been less well investigated. Methods: Magnetic resonance imaging data and cognitive assessments were acquired in 31 patients with psychosis, 32 non-psychotic first-degree relatives and 28 controls. The relationship between cerebral grey matter density and cognitive performance was examined using computational morphometry. Results: Two out of 6 cognitive tests revealed significant associations with grey matter density in regions of the frontal lobe, basal ganglia, thalamus and cerebellum in patients and relatives. In patients, poorer executive functioning was associated with cerebellar grey matter density deficits. In relatives, poorer executive functioning was associated with increased grey matter density in the cerebellum and frontal lobe. In both patients and relatives, strategic retrieval from semantic memory was positively associated with grey matter density in basal ganglia structures. Some additional negative associations in the patients differentiated this group from relatives. Conclusions: The overlap in structure-function relationships in individuals with schizophrenia and those with liability for the disorder may suggest that regional grey matter density alterations functionally alter particular neurocircuits, which could lead to cognitive deficits. The non-overlapping structure-function correlations may reflect disease-related or compensatory mechanisms.

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Impaired Intellect and Memory

Toulopoulou¹,

Goldberg²,

Mesa³

et al. 2010

Arch Gen Psychiatry

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104

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The relationship between volumetric brain changes and cognitive function: A family study on schizophrenia

Cited by 77 publications

References 45 publications

Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Cognitive Performance and Grey Matter Density in Psychosis: Functional Relevance of a Structural Endophenotype

Impaired Intellect and Memory

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