The relationship between women’s body mass index and breast cancer outcomes was U-shaped

Wei, Wensong; Wei, Suosu; Huang, Zhen; Zhang, Qiuhuan; Liu, Fei; Xie, Yujie; Wei, Jing; Mo, Clifton C.; Zhou, Ying; Qin, Shu Kui; Zou, Quanqing; Yang, Jianrong

doi:10.3389/fonc.2023.1191093

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Over the past few years, several studies have shown that a high FFA level was an independent risk factor for several types of malignancy, such as lung cancer, gastric cancer, thyroid cancer, colon cancer, rectal cancer, ovarian cancer (Zhang et al 2020b(Zhang et al , 2022. Recently, a retrospective analysis of 1049 cases of breast cancer indicated that BMI was an independent prognostic factor for BC, and had a U-shaped relationship with OS and breast cancer-speci c survival (BCSS) (Wei et al 2023). Although the underlying mechanisms of BMI and BC outcomes have been well studied, the relationship between serum FFA levels and BC prognostic curves in different BMI subgroups remains unknown.…”

Section: Introductionmentioning

confidence: 99%

The association of preoperative serum free fatty acid with the survival in breast cancer patients

Li,

Jin,

You

et al. 2024

Preprint

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Background Several studies have analyzed the association between serum free fatty acid (FFA) and several types of cancer. However, the role of preoperative serum FFA and breast cancer (BC) prognosis remains largely unclear. This study aimed to elucidate the specific relationship between FFA and BC outcomes. Methods A retrospective review was conducted on 4133 breast cancer patients admitted to Sun Yat-sen Memorial Hospital from January 2015 to October 2021. Restricted cubic splines and multivariate Cox regression analyses were used to assess the relationship between preoperative serum FFA and overall survival (OS) in BC patients. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated. Results Restricted cubic spline analysis revealed a U-shaped relationship between preoperative serum FFA levels and OS after adjusting for other variables. According to the cutoff points of FFA, multivariate Cox regression analyses showed that patients with low FFA levels (≤ 250µmol/L) had higher rates of all-cause mortality and cancer-specific mortality compared to patients with high FFA levels (250–715µmol/L) in total population and those with a BMI of 18.5 to 24.0 kg/m2. Conclusion A nonlinear U-shaped association was identified between preoperative serum FFA levels and the survival in BC patients, with lower FFA levels associated with worse OS.

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Section: Introductionmentioning

confidence: 99%

The association of preoperative serum free fatty acid with the survival in breast cancer patients

Li,

Jin,

You

et al. 2024

Preprint

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The effect of BMI on survival outcome of breast cancer patients: a systematic review and meta-analysis

Kong,

Huang,

Ding

et al. 2024

Clin Transl Oncol

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The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype

Ma,

Liu,

Gao

et al. 2023

Open Life Sciences

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There is growing evidence that higher body mass index (BMI) is associated with lower survival in breast cancer patients. The aim of this study was to investigate whether there is an association between body mass index (BMI) at breast cancer diagnosis and breast cancer prognosis and whether this association is dependent on menopausal status and tumor subtype in a less developed population in northern China. We collected 1,225 patients with primary invasive cancer in stage I-IIIC for retrospective analysis from October 2010 to December 2020. We used Kaplan–Meier and Cox regression analyses and estimated the relationship between baseline BMI and breast cancer-specific survival (BCSS). Next, we further evaluated whether the effect of BMI on breast cancer prognosis differed by menopausal status and tumor subtype. We found that death rate and prognosis were worse for patients with BMI ≥ 24, more than four positive lymph nodes, and triple negative status. Interestingly, BMI played a different prognostic role depending on tumor subtype and menopausal status. For premenopausal women, patients with BMI ≥ 24 had significantly lower BCSS compared to those with BMI < 24 in human epidermal growth factor receptor 2 (HER2) overexpression (HR: 4.305, p = 0.004) and triple negative subtypes (HR: 1.775, p = 0.048). By contrast, there was no association between BMI ≥ 24 and higher death regardless of tumor subtype in post-menopausal patients (p > 0.05). BMI influences breast cancer outcome depending on tumor subtype and menopause. BMI ≥ 24 might be a risk factor for BCSS, particularly in premenopausal women with HER2 overexpression or triple negative subtype. In contrast, BMI ≥ 24 was not associated with higher death regardless of tumor subtype in post-menopausal patients.

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The relationship between women’s body mass index and breast cancer outcomes was U-shaped

Cited by 3 publications

References 39 publications

The association of preoperative serum free fatty acid with the survival in breast cancer patients

The association of preoperative serum free fatty acid with the survival in breast cancer patients

The effect of BMI on survival outcome of breast cancer patients: a systematic review and meta-analysis

The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype

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