The Relationship of Abdominal Fat Mass Assessed by Helical or Conventional Computed Tomography to Serum Leptin Concentration

Kobayashi, Junji; Sasaki, Takeyoshi; Watanabe, Mitsuyo

doi:10.5551/jat.11.173

Cited by 10 publications

(11 citation statements)

References 38 publications

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“…Leptin concentrations have been reported to be associated with BMI and body fat (Ryan and Elahi 1996). Furthermore, Kobayashi et al (2004) showed the relationship between intraabdominal visceral fat mass by CT and serum leptin. Thus, our findings may reveal that hypoxic training is useful in the prevention of MS.…”

Section: Discussionmentioning

confidence: 97%

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Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects

et al. 2014

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The purpose of this study was to investigate the influence of hypoxic physical exercise on metabolic syndrome (MS) risk markers and high‐sensitivity C‐reactive protein (CRP) and to compare its effects on preperitoneal fat, arterial stiffness, and several blood parameters related to MS to those of a control group who trained under normoxic conditions. Fourteen healthy men were examined. Participants performed treadmill exercise 3 days per week for 4 weeks, under either normobaric hypoxic or normobaric normoxic conditions, for 50 min (including a 5‐min warm‐up and 5‐min cool down) after a 30‐min rest period. Exercise was performed at a heart rate (HR) corresponding to 60% of the HR at each individual's maximum oxygen uptake. Training under the different environmental conditions was performed 4 months apart to ensure a sufficient washout period. Waist circumference, preperitoneal fat thickness, brachial‐ankle pulse wave velocity, and high‐sensitivity CRP after training were significantly lower in the hypoxic group than in the normoxic group. Our results suggest that regular short‐term hypoxic training may more effectively reduce arterial stiffness, and thus prevent arteriosclerosis, compared to training performed at a similar exercise intensity under normoxic conditions.

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Section: Discussionmentioning

confidence: 97%

“…Furthermore, Kobayashi et al. () showed the relationship between intraabdominal visceral fat mass by CT and serum leptin. Thus, our findings may reveal that hypoxic training is useful in the prevention of MS.…”

Section: Discussionmentioning

confidence: 99%

Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects

et al. 2014

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“…Leptin is an anorexigenic metabolic hormone that is secreted in proportion to fat mass [23] and decreases bone formation [24]. A strong positive correlation between fat mass and serum leptin concentrations has been reported [25]. …”

Section: Discussionmentioning

confidence: 99%

Psychological state, quality of life, and body composition in postmenopausal women with osteoporosis in Lithuania

Lašaitė¹,

Krasauskienė²

2009

Arch Osteoporos

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SummaryThe objective of this study was to determine body composition, physical activity, and psychological state in postmenopausal women with osteoporosis. Fat mass, lean mass, water mass, and basal metabolic rate are lower, self-reported physical activity and risk factors of fractures are higher, and cognitive functions were worse in osteoporotic patients than in controls. Significant correlations were found between physical activity and emotional state parameters.IntroductionThis study aims to determine peculiarities of body composition, physical activity, risk factors predicting fractures, psychological state and quality of life, and possible relations between them in postmenopausal women with osteoporosis in Lithuania.MethodsThirty-one postmenopausal women with osteoporosis and 29 healthy age- and sex-matched controls were included in the study. Profile of Mood State and Hospital Anxiety and Depression Scale were used for the assessment of emotional state. Trail Making Test and Digit Symbol Test of Wechsler Adult Intelligence Scale were used to evaluate cognitive functioning. Quality of life was evaluated using the World Health Organization Brief Quality of Life Questionnaire. Risk of fractures was assessed by the Risk Factors Predicting Questionnaire.ResultsFat mass (22.4 ± 4.7 vs. 40.6 ± 14.2 kg, p < 0.001), lean mass (37.3 ± 6.0 vs. 48.1 ± 7.6 kg, p < 0.001), water mass (31.6 ± 2.9 vs. 38.3 ± 5.3 kg, p < 0.001), and basal metabolic rate (1,253 ± 132 vs. 1,456 ± 126 kcal, p < 0.001) were lower in osteoporotic patients than in controls. Self-reported physical activity (2.35 ± 0.6 vs. 1.69 ± 0.5, p < 0.001) and risk factors of fractures (5.9 ± 2.1 vs. 2.6 ± 2.4, p < 0.001) were higher in women with osteoporosis than in healthy age- and sex-matched controls (2.35 ± 0.6 vs. 69 ± 0.5, p < 0.001). Trail making A and B scores were higher in patients than in age- and sex-matched controls (55.8 ± 19.9 vs. 45.1 ± 19.9, p = 0.07 and 118.2 ± 34.6 vs. 92.8 ± 48.7, p = 0.006). Some significant correlations were detected between physical activity and emotional state and quality of life parameters.ConclusionIn postmenopausal women with osteoporosis, fat body mass, lean body mass, water body mass, basal metabolic rate, and waist-to-hip ratio are lower, physical activity and risk of fractures are higher, and cognitive functions are worse than in age- and sex-matched controls. Some psychological peculiarities could be related to physical activity in women with osteoporosis.

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“…Leptin's anti-osteogenic action was demonstrated by intracerebroventricular injection of leptin into an ob/ob mouse, which decreased bone formation (19). A strong positive correlation between fat mass and serum lipid concentrations has been reported (20). Studies have shown that hyperlipidemia may contribute to osteoporosis by increasing osteoclastic bone resorption (21) and osteoclast viability (22).…”

Section: Introductionmentioning

confidence: 99%

Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women

Hsu

Venners

Terwedow

et al. 2006

The American Journal of Clinical Nutrition

466

273

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Background: Higher fat mass may be an independent risk factor for osteoporosis and osteoporotic fractures. Objective: We aimed to determine the independent contribution of fat mass to osteoporosis and to estimate the risk of osteoporotic fractures in relation to body weight, lean mass, and other confounders. Design: This was a community-based, cross-sectional study of 7137 men, 4585 premenopausal women, and 2248 postmenopausal women aged 25-64 y. Total-body and hip bone mineral content (BMC) and bone mineral density (BMD) and body composition were measured by dual-energy X-ray absorptiometry. Serum lipids were measured. Sex-and menopause-specific multiple generalized linear models were applied. Results: Across 5-kg strata of body weight, fat mass was significantly inversely associated with BMC in the whole body and total hip. When we compared the highest quartile with the lowest quartile of percentage fat mass in men, premenopausal women, and postmenopausal women, the adjusted odds ratios (95% CIs) of osteoporosis defined by hip BMD were 5.2 (2.1, 13.2), 5.0 (1.7, 15.1), and 6.9 (4.3, 11.2), respectively. Significant linear trends existed for higher risks of osteoporosis, osteopenia, and nonspine fractures with higher percentage fat mass. Significant negative relations were found between whole-body BMC and cholesterol, triacylglycerol, LDL, and the ratio of HDL to LDL in all groups. Conclusions: Risks of osteoporosis, osteopenia, and nonspine fractures were significantly higher for subjects with higher percentage body fat independent of body weight, physical activity, and age. Thus, fat mass has a negative effect on bone mass in contrast with the positive effect of weight-bearing itself.Am J Clin Nutr 2006; 83:146 -54.

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The Relationship of Abdominal Fat Mass Assessed by Helical or Conventional Computed Tomography to Serum Leptin Concentration

Cited by 10 publications

References 38 publications

Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects

Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects

Psychological state, quality of life, and body composition in postmenopausal women with osteoporosis in Lithuania

Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women

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