The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults

Jung, Chan-Hee; Rhee, Eun-Jung; Choi, Ji‐Hoon; Bae, Ji-Cheol; Yoo, Seunghyun; Kim, Won-Jun; Park, Cheol‐Young; Mok, Ji Oh; Kim, Chul-Hee; Lee, Won Young; Oh, Ki-Won; Park, Sung Woo; Kim, Sun-Woo

doi:10.4093/kdj.2010.34.4.237

Cited by 64 publications

(55 citation statements)

References 21 publications

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“…It was reported that the A/L ratio gradually decreases with the number of MetS components (27). In addition, it is suggested that the A/L ratio is more effective in relevance as a parameter of insulin resistance compared with adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than HOMA-IR in patients with type 2 diabetes (28).…”

Section: Discussionmentioning

confidence: 99%

Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome?

Kural

Erem²,

Yucesan³

2014

Turk J Med Sci

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IntroductionMetabolic syndrome (MetS) is a clustering of cardiovascular risk factors associated with insulin resistance, central adiposity, hyperglycemia, hypertension, hypertriglyceridemia, and low high-density lipoprotein cholesterol (HDL-C) levels (1,2).Adipokines are secreted by adipose tissue and influence a variety of physiological processes such as food intake control, energy homeostasis, insulin sensitivity, angiogenesis, blood pressure regulation, and blood coagulation (3). They play significant roles in the pathogenesis of obesity, MetS, and chronic inflammatory and autoimmune diseases (4). Leptin is one adipokine that contributes to the regulation of body weight, modulation of insulin sensitivity, metabolism, and reproductive function (5). In addition, it affects thermogenesis, hematopoiesis, angiogenesis, and immune homeostasis (6). Another adipokine, adiponectin, produced exclusively by adipocytes of white adipose tissue, plays a significant role in the regulation of insulin sensitivity and has antiatherosclerotic and antiinflammatory properties (3). Resistin is another adipokine that may be involved in sensing the nutritional status-its mRNA level decreases during fasting and increases after food consumption. It is associated with a variety of disorders: obesity, diabetes, atherosclerosis, endothelial dysfunction, thrombosis, angiogenesis, inflammation, and smooth muscle cell dysfunction (4,7). The adipokine visfatin shows insulinlike properties, inhibits glucose release by liver cells, and promotes the storage of triglycerides in preadipocytes (8). It plays roles in immunity, metabolism, aging and Background/aim: To determine the levels of adipokines (leptin, adiponectin, resistin, and visfatin) and the indices of insulin sensitivity/ resistance, and to examine the relationship among them in patients with metabolic syndrome (MetS). Materials and methods:The study groups included 45 subjects with MetS (31 women/14 men), and 45 sex-and age-matched non-MetS healthy volunteers (31 women/14 men). The levels of adipokines were determined by enzyme-linked immunosorbent assay. Results:The levels of leptin and visfatin were significantly higher in the MetS than in the non-MetS subjects (P < 0.01). There was no difference in adiponectin levels in subjects with and without MetS (P = 0.052). Similarly, resistin did not show any statistically significant difference. A statistically significant positive correlation of leptin with insulin levels was observed, while negative correlations of visfatin levels with age, and resistin levels with the ratio of adiponectin to leptin, were found in the MetS (P < 0.05). The combination of adipokines, insulin resistance-sensitivity parameters, and MetS criteria parameters gave more significant differences than a single parameter. Conclusion:Since the parameters mentioned above might affect, interact with, and/or interfere with each other, the combinations of these parameters might give more reliable results to evaluate the insulin resistance/sensitivity in MetS patients.

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Section: Discussionmentioning

confidence: 99%

Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome?

Kural

Erem²,

Yucesan³

2014

Turk J Med Sci

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“…Уровень адипонектина снижается у лиц с ожирени-ем, а повышение его концентрации обладает ано-рексигенным эффектом и сопровождается сниже-нием массы тела [64]. Как адипонектин, так и леп-тин продуцируется жировой тканью и оказывает влияние на потребление пищи, инсулинорезистент-ность, а также липолиз [65,66]. В 32-недельном рандомизированном перекрест-ном исследовании изучалось влияние инсулина де-темир на потребление пищи и массу тела у пациен-тов с СД1 (n=23) [56].…”

Section: терапия детемиром и реакция гормонов регулирующих аппетитunclassified

Detemir (Levemir): modern paradigms of insulin therapy

Руяткина¹,

Sorokin²

2013

Probl Endokrinol (Mosk)

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Peculiarities of the molecular structure of Levemir (detemir) account for low variability of its pharmacodynamic properties and are responsible for the more predictable hypoglycemic effect and the lower risk of general and nocturnal hypoglycemic episodes in different age-groups of the patents suffering type 1 and 2 diabetes mellitus compared with other preparations of basal insulin. Moreover, insulin detemir (Levemir) does not affect the body weight of the patients due to its central action (rapid penetration across the hematoencephalic barrier, control of hunger and satiation, improved recognition of hypoglycemic states) and the influence on the synthesis of hormones regulating appetite and energy metabolism. Insulin detemir is shown to possess neurotropic properties, such as hepato-selective action on the liver, lipid metabolism, and sodium re-absorption.

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“…67 Both adiponectin and leptin are derived from adipose tissue and they influence food intake, insulin resistance, and lipolysis. 68,69 Comparison of the effects of insulin detemir and human insulin on 3T3-L1 preadipocytes indicated that human insulin, but not insulin detemir, was associated with clonal expansion and that insulin detemir had reduced adipogenic effects versus human insulin. 70 Thus, while the mechanisms underlying lower weight gain with insulin detemir versus other insulins are not clear, it is reasonable to speculate that they may involve albumin binding, preferential activity in brain and liver, and favorable effects on adipocytes.…”

Section: Cns Influencesmentioning

confidence: 99%

Insulin detemir for the treatment of obese patients with type 2 diabetes

Hollander¹

2012

DMSO

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Abstract:The risk for developing type 2 diabetes (T2DM) is greater among obese individuals. Following onset of the disease, patients with T2DM become more likely to be afflicted with diabetic micro-and macrovascular complications. Decreasing body weight has been shown to lower glycosylated hemoglobin and improve other metabolic parameters in patients with T2DM. Medications used to lower blood glucose may increase body weight in patients with T2DM and this has been repeatedly shown to be the case for conventional, human insulin formulations. Insulin detemir is a neutral, soluble, long-acting insulin analog in which threonine-30 of the insulin B-chain is deleted, and the C-terminal lysine is acetylated with myristic acid, a C14 fatty acid chain. Insulin detemir binds to albumin, a property that enhances its pharmacokinetic/ pharmacodynamic profile. Results from clinical trials have demonstrated that treatment with insulin detemir is associated with less weight gain than either insulin glargine or neutral protamine Hagedorn insulin. There are many potential reasons for the lower weight gain observed among patients treated with insulin detemir, including lower risk for hypoglycemia and therefore decreased defensive eating due to concern about this adverse event, along with other effects that may be related to the albumin binding of this insulin that may account for lower within-patient variability and consistent action. These might include faster transport across the blood-brain barrier, induction of satiety signaling in the brain, and preferential inhibition of hepatic glucose production versus peripheral glucose uptake. Experiments in diabetic rats have also indicated that insulin detemir increases adiponectin levels, which is associated with both weight loss and decreased eating.

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The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults

Cited by 64 publications

References 21 publications

Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome?

Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome?

Detemir (Levemir): modern paradigms of insulin therapy

Insulin detemir for the treatment of obese patients with type 2 diabetes

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