The relationship of breast density in mammography and magnetic resonance imaging in high-risk women and women with breast cancer

Albert, Marissa; Schnabel, Freya; Chun, Jennifer; Schwartz, Shira; Lee, Jiyon; Leite, Ana Paula Klautau; Moy, Linda

doi:10.1016/j.clinimag.2015.08.001

Cited by 21 publications

(18 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,21,22 Although fibroglandular tissues are also enhanced on MRI, MRI allows cross-sectional contiguous slice imaging, and occult cancers can be detected on MRI using meticulous, consistent technique and image interpretation. 23,24 This is consistent with a recent prospective randomized trial for patients with extremely dense breasts which has shown better detection (fewer interval cancers) compared to mammography. 25 Thus, our results suggest that mammographic density should be considered among indications for preoperative MRI.…”

Section: Factors Associated With Detection Of Occult Cancersupporting

confidence: 86%

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers

Wecsler

Jeong

Raghavendra

et al. 2020

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background The use of preoperative magnetic resonance imaging (MRI) for newly diagnosed breast cancer remains controversial. We examined factors associated with detection of occult multicentric, multifocal, and contralateral malignant lesions only seen by MRI. Methods We performed a retrospective analysis of consecutive patients undergoing preoperative MRI for breast cancer. Clinicopathologic data were assessed regarding the findings of multifocality, multicentricity, and the presence of contralateral lesions. We analyzed the association of factors with these findings on MRI. Results Of 857 patients undergoing MRI, 770 patients met inclusion criteria. Mean age was 54.7 years. Biopsy‐proven detection rates by MRI for multifocal, multicentric, and contralateral cancers were 6.2% (48 of 770), 1.9% (15 of 770) and 3.1% (24 of 770), respectively. African American race and heterogeneously or extremely dense mammographic density were associated with multifocal cancers on MRI. Larger lesion size and mammographic density were associated with multicentric cancers. Invasive lobular carcinoma (ILC) and progesterone receptor (PR)‐positivity were associated with contralateral cancers. Conclusions African American race, heterogeneously or extremely dense mammographic density, ILC, and PR‐positivity were associated with additional biopsy‐proven cancers based on MRI. These factors should be considered when assessing the clinical utility of preoperative breast MRI.

show abstract

Section: Factors Associated With Detection Of Occult Cancersupporting

confidence: 86%

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers

Wecsler

Jeong

Raghavendra

et al. 2020

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Breast MRI screening today is mainly suggested only for women with high-risk backgrounds in current international guidelines, such as those published by the European Society of Breast Imaging, the European Society of Breast Cancer Specialists, and the American College of Radiology [20] , [23] , [24] . At the same time, there are only few studies examining BPE promoting factors in high-risk populations [6] , [23] , [25] , [26] .…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE?

You

Kaiser

Baltzer

et al. 2018

Translational Oncology

View full text Add to dashboard Cite

OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression. RESULTS: BPE positively correlated with FGT (P < .001) and negatively correlated with menopausal status (P < .001). Cancer did not show an effect on BPE (P > .05). A high-risk precondition showed a significant impact on the formation of BPE (P < .05). However, when corrected for motion, the correlation between BPE and a high-risk precondition became weak and insignificant, and a highly significant association between BPE and motion was revealed (P < .01). CONCLUSION: BPE positively correlated with FGT and negatively correlated with age. Cancer did not have an effect on BPE. A high-risk precondition appears to have a negative effect on BPE. However, when corrected for motion, high-risk preconditions became insignificant. Technical as well as physiological influences seem to play an important role in the formation of BPE.

show abstract

“…8,10,[12][13][14][15]21,23,26,28,[32][33][34][35][36]38,[40][41][42][43][48][49][50][51][52][53][54]57,59,61 In five studies, 11,17,19,29,44 the authors acknowledged that owing to the retrospective nature of the study, it was not possible to analyze the point of menstrual cycle, although, following institutional protocol, screening breast MRI of patients who were pre-menopausal was performed during the second week of the menstrual cycle. In a total of 14 studies, the authors stated the menstrual period.…”

Section: Quantitative Background Parenchymal Enhancement Assessmentmentioning

confidence: 99%

Evaluation of background parenchymal enhancement on breast MRI: a systematic review

Bignotti¹,

Signori²,

Valdora³

et al. 2017

The British Journal of Radiology

View full text Add to dashboard Cite

Objective: To perform a systematic review of the methods used for background parenchymal enhancement (BPE) evaluation on breast MRI. Methods: Studies dealing with BPE assessment on breast MRI were retrieved from major medical libraries independently by four reviewers up to 6 October 2015. The keywords used for database searching are "background parenchymal enhancement", "parenchymal enhancement", "MRI" and "breast". The studies were included if qualitative and/or quantitative methods for BPE assessment were described. Results: Of the 420 studies identified, a total of 52 articles were included in the systematic review. 28 studies performed only a qualitative assessment of BPE, 13 studies performed only a quantitative assessment and 11 studies performed both qualitative and quantitative assessments. A wide heterogeneity was found in the MRI sequences and in the quantitative methods used for BPE assessment. Conclusion: A wide variability exists in the quantitative evaluation of BPE on breast MRI. More studies focused on a reliable and comparable method for quantitative BPE assessment are needed. Advances in knowledge: More studies focused on a quantitative BPE assessment are needed.

show abstract

The relationship of breast density in mammography and magnetic resonance imaging in high-risk women and women with breast cancer

Cited by 21 publications

References 58 publications

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers

The Assessment of Background Parenchymal Enhancement (BPE) in a High-Risk Population: What Causes BPE?

Evaluation of background parenchymal enhancement on breast MRI: a systematic review

Contact Info

Product

Resources

About