The relationship of clinical response, oocyte number, and success in oocyte donor cycles

Letterie, Gerard S.; Marshall, Lorna; Angle, M

doi:10.1007/s10815-005-4875-9

Cited by 18 publications

(11 citation statements)

References 8 publications

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“…One of the most important issues in an egg donor program is to have a good screening protocol, where only potentially successful donors are accepted into the program. Unfortunately, this is not an easy task and studies showed that selecting only young donors, [16,17] failed to show any variables that would make a difference in future outcome [18][19][20]. In our program, we include donors younger than 35 years old with regular menses, with normal basal FSH/estradiol levels and basal antral follicle count, without androgenic characteristics, and without history of repeated spontaneous miscarriages.…”

Section: Discussionmentioning

confidence: 99%

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

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Purpose To evaluate which is the minimum number of oocytes to be allocated to each recipient in a shared egg donor program. Methods We analyzed 953 recipients that received at least 4 metaphase II (MII) oocytes in the period 2006-2008. We retrospectively divided the recipients according to the number of MII oocytes actually received.Results No statistically significant differences were found among the analyzed strata in clinical pregnancy rate (A:43.7%; B:45.6%; C:48.6%; D:45.5%; E:53%, P=NS) and miscarriage rate. However, the rate of top quality transferred embryos, and the embryo freezing rate were significantly higher among those recipients that received 7 or more mature eggs. Conclusions After a large sample was analyzed, no significant differences in fresh embryo transfer outcome were encountered when a different number of oocytes was allocated. A minimum of 4 MII oocytes seems to achieve satisfactory pregnancy rates in our shared egg donor program.

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Section: Discussionmentioning

confidence: 99%

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

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“…One study showed that when an infertile patient shared either 8 or 12 oocytes with another patient, each patient receiving 4 or 6 oocytes, respectively, there was no difference in LBR (25.7% vs. 28.2%, respectively) (23). Furthermore, another study showed that there was no statistical difference in PR when the total number of oocytes given to a recipient from a fertile voluntary donor ranged from 4 to >25 (24). Perhaps IVF programs should seriously consider sharing the cohort of fertile donor oocytes among three recipients instead of two to more efficiently use this valuable resource, reduce the medical risks to donors and costs to recipients, and still maintain a high cumulative PR.…”

Section: Figurementioning

confidence: 99%

Comparison of pregnancy outcomes in anonymous shared versus exclusive donor oocyte in vitro fertilization cycles

Mullin

Fino

Talebian

et al. 2010

Fertility and Sterility

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“…Following adjustment for oocyte donor age, Cohen et al found that the number of oocytes was not associated with pregnancy outcome (7,12). Additionally, Letterie et al found that there were no differences in fertilization rates or clinical pregnancy rates regardless of the number of oocytes retrieved, ranging from 3 to >25 (13). Given these inconsistent findings, it has been difficult to interpret contradictory results.…”

Section: Introductionmentioning

confidence: 99%

Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles

Hariton

Kim

Palmor

et al. 2017

Fertility and Sterility

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Objective To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate (LBR) following fresh donor oocyte IVF-embryo transfer (IVF-ET). Design Retrospective cohort study. Setting Academic reproductive medicine practice Patients Two hundred and thirty-seven consecutive fresh donor oocyte IVF-ET cycles from January 1, 2007 to December 31, 2013 at the Massachusetts General Hospital Fertility Center. Interventions None. Main Outcome Measure Live birth rate per cycle initiated Results The mean (± standard deviation) age of oocyte donors and recipients was 27.0 (± 3.7) and 41.4 (± 4.6) years, respectively. Oocyte donor demographic/reproductive characteristics, ovarian reserve testing, and peak serum estradiol during ovarian stimulation (OS) were similar among cycles which did and did not result in live birth (LB), respectively. Overall implantation, clinical pregnancy, and LBR per cycle initiated were 40.5%, 60.8%, and 54.9%, respectively. The greatest probability of LB was observed in cycles with >10 oocytes retrieved, mature oocytes, oocytes with normal fertilization (zygote-two pronuclear stage), and cleaved embryos, respectively. Conclusion The number of oocytes (total and mature), zygotes, and cleaved embryos are associated with LB following donor oocyte IVF cycles. These findings suggest that specific peri-fertilization factors may be predictive of pregnancy outcomes following donor oocyte IVF cycles.

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The relationship of clinical response, oocyte number, and success in oocyte donor cycles

Cited by 18 publications

References 8 publications

A shared egg donor program: which is the minimum number of oocytes to be allocated?

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Comparison of pregnancy outcomes in anonymous shared versus exclusive donor oocyte in vitro fertilization cycles

Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles

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