The relationship of diabetes, periodontitis and cardiovascular disease

Khumaedi, Anandhara Indriani; Purnamasari, Dyah; Wijaya, Ika Prasetya; Soeroso, Yuniarti

doi:10.1016/j.dsx.2019.03.023

Cited by 78 publications

(81 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, CP can impair metabolic control in patients with DM. 9 Patients with T2DM have a greater prevalence, extent, and severity of CP than non-diabetic subjects. 10 The accumulation of anaerobic gram-negative bacteria can cause the CP and formation of calculus.…”

Section: Introductionmentioning

confidence: 99%

<p>Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial</p>

Javid¹,

Hosseini²,

Gholinezhad³

et al. 2020

DMSO

View full text Add to dashboard Cite

Background and Aim: The imbalance between pro-oxidant and antioxidant systems often leads to further oxidative damage in the pathogenesis of both diabetes and periodontal disease. This study aimed to investigate the antioxidant and anti-inflammatory properties of melatonin in type 2 diabetes mellitus (T2DM) patients with periodontal disease (PD) under non-surgical periodontal therapy (NSPT). Materials and Methods: In this double-blind clinical trial study, 50 T2DM patients with PD were randomly allocated to intervention and control groups and received 250 mg/day (2 tablets) either melatonin or placebo 1 h before bedtime for 8 weeks. The NSPT was performed for all patients in both groups at the beginning of the study. The serum levels of interleukin-1b (IL-1b), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured pre-and post-intervention. Results: Supplementation with melatonin in adjunct to NSPT significantly increased the serum levels of TAC, SOD, CAT, and GPx in the intervention group (P = 0.02, 0.008, 0.004 and 0.004, respectively). The mean changes of SOD, CAT, and GPx were significantly (P = 0.02, 0.04 and 0.04, respectively) greater in the intervention group compared with the control group. Also, after adjusting for confounding factors, the results did not change in terms of significance (P < 0.05). After the intervention, serum levels of MDA and IL-1b were significantly reduced in the intervention group (P < 0.001 and P = 0.008, respectively). The intervention group exhibited lower mean changes of MDA compared with the control group, and these changes were statistically significant (P = 0.008). In addition, after adjusting for confounding factors, the results did not change in terms of significance. Conclusion: The adjunctive effects of melatonin and NSPT may improve inflammatory and antioxidant parameters in T2DM patients with PD.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial</p>

Javid¹,

Hosseini²,

Gholinezhad³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Periodontitis is one of the most frequent chronic conditions in human adults, affecting more than 42% of US adults 30 years of age or older [1]. It is a leading cause of tooth loss among adults and has been reported to have a harmful impact on general health and wellbeing [2][3][4][5][6][7]; periodontitis has been associated with diabetes, cardiovascular disease and adverse pregnancy outcomes [3][4][5][6][7]. It is a multifactorial disease that entails complex infectious and immunological interactions [8].…”

Section: Introductionmentioning

confidence: 99%

Is inadequate sleep a potential risk factor for periodontitis?

Alhassani

Al-Zahrani

2020

PLoS ONE

View full text Add to dashboard Cite

This study was undertaken to investigate the potential association between sleep duration and periodontitis. The study population consisted of 10,291 individuals who participated in the United States National Health and Nutrition Examination Survey (NHANES) from the 2009-2014 cycles. Sleep duration was categorized into sleep deficient (< 7 hours), sleep adequate (7-8 hours), and sleep excessive (> 8 hours). We used the Center for Disease Control and Prevention (CDC) and the American Academy of Periodontology (AAP) periodontitis case definition. Descriptive statistics and logistic regression models were used for data analyses. The prevalence of periodontitis was 36% higher in individuals who reported sleep deficiency when compared to the sleep adequate group (odds Ratio (OR) = 1.36, 95% confidence interval (CI): 1.23-1.50). Those who reported excessive sleep had 41% higher odds of periodontitis (OR: 1.40, 95% CI: 1.16-1.71). After adjusting for confounding factors, sleep deficient individuals were 19% more likely to have periodontitis when compared to sleep adequate individuals (OR: 1.19, 95% CI: 1.06-1.38). Among sleep excessive individuals, the association was non-significant (OR: 1.16, 95% CI: 0.94-1.43). Sleep deficiency was associated with a higher prevalence of periodontitis in this study population. The association however needs to be confirmed in longitudinal studies.

show abstract

“…The increase of HDL level can prevent the formation of bone marrow, monocyte and neutrophil induced by diabetes, and reduce the cardiovascular risk of diabetic patients [46]. More and more evidences show that the increase of monocytes caused by diabetes aggravates the process of cardiovascular disease, especially atherosclerosis [47][48][49]. Whether monocyte and macrophage changes are caused by altered glucose levels, insulin deficiency or insulin resistance, lipid abnormalities, or a combination of these factors is still debated.…”

Section: Resultsmentioning

confidence: 99%

Predictive value of monocyte to high-density lipoprotein ratio for the estimation of diabetes mellitus risk: Insights from a general population

Qian

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundMonocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel inflammatory marker of inflammation and oxidative stress and has been used to predict multiple inflammation-related diseases, but data relative to diabetes mellitus are lacking. Hence, our study aimed to explore the impact of MHR on diabetes and its value to improve the risk stratification and prevention of diabetes in a large cohort of general Chinese population.MethodThis study selected 8142 (males: 45.76%) participants who participated in the rural cardiovascular health research in Northeast China between 2012 and 2013. MHR was defined as blood monocyte count ratio to high-density lipoprotein cholesterol concentrationResultsThe prevalence of diabetes is 10.7%. By correcting for potential confounding factors, per SD increase of MHR caused a 11.2% additional risk for diabetes, in addition, the top quartile of MHR increased the risk of diabetes by 33.1% over the bottom quartile.Furthermore, smooth curve fitting showed a linear and strong correlation between MHR and diabetes. Finally, Category-free net reclassification improvement (0.085, 95% CI: 8 0.016-0.155, P = 0.016) and integrated discrimination improvement (0.001, 95% CI: 0.000-0.0024, P = 0.018) also demonstrated significant improvementsConclusionsOur study revealed an independent and robust correlation between MHR and prevalent diabetes mellitus in general population. Furthermore, our results suggest the importance of simultaneous inflammation and lipids control in the prevention of diabetes mellitus, highlighting the value of MHR to optimize the risk stratification and prevention of diabetes mellitus. These findings have implications for the prevention of diabetes and its adverse outcomes.

show abstract

The relationship of diabetes, periodontitis and cardiovascular disease

Cited by 78 publications

References 24 publications

<p>Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial</p>

<p>Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial</p>

Is inadequate sleep a potential risk factor for periodontitis?

Predictive value of monocyte to high-density lipoprotein ratio for the estimation of diabetes mellitus risk: Insights from a general population

Contact Info

Product

Resources

About