The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

Aydoğdu, Aydoğan; Üçkaya, Gökhan; Taşçı, İlker; Baysan, Oben; Tapan, Serkan; Buğan, Barış; Serdar, Muhittin; Akbulut, Halil; Aydoğan, Ümit; Sönmez, Alper; Aydogdu, Sebnem; Kutlu, Mustafa

doi:10.1507/endocrj.ej11-0328

Cited by 13 publications

(14 citation statements)

References 35 publications

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“…EFT was positively correlated with BMI and WC but not with FPG level or HbA1c, which is similar to a previous report (44). However, contrary to a previous report, EFT was not correlated with the TG, LDL, or HDL levels in our study (46).…”

Section: Discussionsupporting

confidence: 83%

Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers

et al. 2015

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Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated with cardiovascular risk factors. We herein aimed to assess EFT in prediabetic patients. Methods We evaluated 64 patients with prediabetes and 30 age-and gender-matched healthy subjects. Demographic and anthropometric characteristics [age, sex, height, weight, body mass index (BMI), and waist circumference (WC)] and laboratory findings [fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides (TG)] were assessed. Transthoracic echocardiography was used to evaluate EFT. Results There were no significant differences between the case and control groups in terms of age, gender, height, HDL, WC, systolic and diastolic blood pressure (SBP/DBP), or TG (p>0.05). Body weight, BMI, FPG, LDL, and, in particular, EFT were found to be significantly higher in the case group than control group (p<0.05). When compared with the control group, the median EFT was significantly higher in all prediabetic subgroups (IGT or IFG, p<0.001). However, no statistically significant difference was found between each case subgroup (p=0.795). When groups were adjusted according to age, sex, WC, and BMI with covariance test, the EFT remained increased in the prediabetes subgroups compared to the controls (p<0.001). Conclusion We found the EFT levels to be increased in all subgroups of prediabetic patients regardless of FPG and HbA1c. Furthermore, EFT directly correlated with the patients' BMI and WC.

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Section: Discussionsupporting

confidence: 83%

Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers

et al. 2015

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“…There are only few studies evaluating the EATT in PCOS patients and in both of the studies EAT was thicker in the PCOS patients [33,34]. In our study, EAT was thicker in the PCOS group, but the difference was not significant.…”

Section: Discussioncontrasting

confidence: 67%

Epicardial adipose tissue thickness and NGAL levels in women with polycystic ovary syndrome

Şahin

Cüre

Uğurlu

et al. 2014

Journal of Ovarian Research

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BackgroundPolycystic ovary syndrome (PCOS) is associated with an increased cardiovascular disease (CVD) risk and early atherosclerosis. Epicardial adipose tissue thickness (EATT) is clinically related to subclinical atherosclerosis. In the present study, considering the major role of neutrophil gelatinase-associated lipocalin (NGAL) which is an acute phase protein rapidly releasing upon inflammation and tissue injury, we aimed to evaluate NGAL levels and EATT in PCOS patients and assess their relationship with cardiometabolic factors.Methods64 patients with PCOS and 50 age- and body mass index-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters. EATT was measured by echocardiography above the free wall of the right ventricle. Serum NGAL and high-sensitive C- reactive protein (hsCRP) levels were measured by ELISA.ResultsMean EATT was 0,38 +/-0,16 mm in the PCOS group and 0,34 +/-0,36 mm in the control group (p = 0,144). In the obese PCOS group (n = 44) EAT was thicker compared to the obese control group (n = 41) (p = 0.026). Mean NGAL levels of the patients with PCOS were 101,98 +/-21,53 pg/ml, while mean NGAL levels were 107,40 +/-26,44 pg/ml in the control group (p = 0,228). We found a significant positive correlation between EATT and age, BMI, waist circumference, fasting insulin, HOMA-IR, triglyceride and hsCRP levels in PCOS group.ConclusionsThickness of the epicardial adipose tissue can be used to follow the risk of CVD development in obese PCOS cases. However serum NGAL levels do not differ in patients with PCOS and control group.

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“…Previous studies showed that there is a linear correlation between thickness of EFT and triglyceride levels (46). In our study, unlike previous studies, no linear correlation could be found between thickness of EFT and triglyceride levels.…”

Section: Discussioncontrasting

confidence: 93%

Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

Ertem¹,

Erayman²,

Efe³

et al. 2014

Anadolu Kardiyol Derg

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Objective: This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness. Methods: Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation between epicardial fat tissue thickness, which was measured by echocardiography and serum paraoxonase 1 level. Also correlation analysis was performed to show correlation between patients' clinical and laboratory findings and the level of serum paraoxonase 1 (PON 1) and the epicardial fat tissue thickness. Pearson and Spearman test were used for correlation analysis. Results: No linear correlation between epicardial fat tissue thickness and serum PON 1 found (correlation coefficient: -0.127, p=0.069). When epicardial fat tissue thickness were grouped as 7 mm and over, and below, and 5 mm and over, and below, serum PON 1 level were significantly lower in ≥7 mm group (PON1 : 168.9 U/L) than <7 mm group (PON 1: 253.9 U/L) (p<0.001). Also hypertension prevalence was increased in ≥7 mm group (p=0.001). Serum triglyceride was found to be higher in ≥7 mm group (p=0.014), body mass index was found higher in ≥5 mm group (p=0.006). Conclusion: Serum PON 1level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness. (Anadolu Kardiyol Derg 2014; 14: 115-20)

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The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

Cited by 13 publications

References 35 publications

Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers

Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers

Epicardial adipose tissue thickness and NGAL levels in women with polycystic ovary syndrome

Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

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