“…Gout, leukemia, and pneumonia had for many years been known to cause this increase, but newer work indicated that in addition, a rise in the level of blood uric acid could be found in pernicious anemia (7), carbon monoxide poisoning (8), toxemias of pregnancy (9), erythemia (10), eczema (11), and during the first few days of life (12). Umeda (13) had shown that normal individuals excreted only small amounts of uric acid when on excessively high fat diets, but it remained for Lennox (14,15) and Harding (16) and his collaborators to show that this decreased excretion was accompanied by a remarkable increase in the blood uric acid either during starvation, or as the result of a ketogenic diet.…”