With the development of science and technology, it brings more possibilities for artistic space design method innovation. The development of computer image data acquisition technology has realized the continuous extension of artistic space design and creation. Based on the computer image data collection technology, this paper realizes the innovative design of real and virtual environment in the exhibition of art space, centering on the interactive integration of the three elements of “human-objects-space.” Through the experimental design, from the space, color data collection, display space moving line, and space function design scheme were the four aspects of exploration and analysis. Compared with traditional design methods, the following conclusions are drawn: first, in spatial data acquisition, the average error of area measurement is less than 3.63%, and the measurement accuracy can reach more than 91%. Second, the average accuracy of color detection of various materials in space can be maintained at 90%. Third, the spatial movement line designed in this paper is simple and clear, with appropriate length, so that visitors can achieve the best visiting effect with the smallest distance. Fourth, the overall design scheme is reasonable, the space is transparent and bright, and the tour route is clear. It can complete the functional zoning design of the art exhibition space in a short time, saving a lot of manpower and time.